9KEZ
 
 | | Crystal structure of the PIN1 and fragment 31 complex. | | Descriptor: | 2,3-dihydro-1,4-benzodioxin-5-ylmethanol, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-11-05 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KF0
 | | Crystal structure of the PIN1 and fragment 32 complex. | | Descriptor: | (2,5-dimethylpyrazol-3-yl)methanol, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-11-05 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KFC
 | | Crystal structure of the PIN1 and fragment 40 complex. | | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-11-05 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KFD
 | | Truncated Fzo1,GTP-bound | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mitofusin FZO1, ... | | Authors: | Yan, L.-M, Gao, S, Huang, S.-J. | | Deposit date: | 2024-11-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly
To Be Published
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9KFE
 | | Truncated Fzo1 with modified LD, GTP-bound | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mitofusin FZO1,Mitofusin FZO1,Fzo1, ... | | Authors: | Gao, S, Huang, S.-J. | | Deposit date: | 2024-11-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly
To Be Published
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9KFF
 | | Truncated Fzo1 with modified LD,transition-like state | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BERYLLIUM TRIFLUORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Gao, S, Huang, S.-J. | | Deposit date: | 2024-11-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly
To Be Published
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9KFH
 | | Crystal structure of the PIN1 and fragment 52 complex | | Descriptor: | 2-methylfuran-3-carboxylic acid, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-11-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KG9
 | | Crystal structure of the PIN1 and fragment 18 complex. | | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 3-methoxythiophene-2-carboxylic acid, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-11-08 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KXH
 | | Crystal structure of the PIN1 and fragment 42 complex | | Descriptor: | 2,6-bis(fluoranyl)benzamide, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-12-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KXI
 | | Crystal structure of the PIN1 and fragment 31 complex. | | Descriptor: | 2-(2-methylimidazol-1-yl)aniline, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-12-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KXJ
 | | Crystal structure of the PIN1 and fragment 53 complex | | Descriptor: | (3S,11R)-tetracyclo[6.3.0.02,6.05,9]undecane-3,11-diol, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-12-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KXL
 | | Crystal structure of the PIN1 and fragment 56 complex. | | Descriptor: | 2-phenoxyethanamine, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-12-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KXM
 | | Crystal structure of the PIN1 and fragment 57 complex. | | Descriptor: | (1~{S})-1-(1~{H}-benzimidazol-2-yl)ethanol, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-12-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KXN
 | | Crystal structure of the PIN1 and fragment 58 complex. | | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 5-methyl-1,2-oxazole-3-carbohydrazide, CHLORIDE ION, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-12-06 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9KXQ
 | | Crystal structure of the PIN1 and fragment 55 complex. | | Descriptor: | (3,5-dimethyl-1,2-oxazol-4-yl)methanol, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... | | Authors: | Xiao, Q.J, Wu, T.T, Shu, H.L, Qin, W.M. | | Deposit date: | 2024-12-07 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Uncovering druggable hotspots on Pin1 via X-ray crystallographic fragment screening.
Eur.J.Med.Chem., 299, 2025
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9L1J
 | | sdAbB YERLA mutant | | Descriptor: | CHLORIDE ION, GLYCEROL, PENTAETHYLENE GLYCOL, ... | | Authors: | Caaveiro, J.M.M, Uto, Y, Tsumoto, K. | | Deposit date: | 2024-12-14 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Improving the solubility of single domain antibodies using VH-like hallmark residues.
Protein Sci., 34, 2025
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9L1K
 | | sdAbA YERLS mutant | | Descriptor: | GLYCEROL, SODIUM ION, SULFATE ION, ... | | Authors: | Caaveiro, J.M.M, Fernandez-Perez, J, Tsumoto, K. | | Deposit date: | 2024-12-14 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Improving the solubility of single domain antibodies using VH-like hallmark residues.
Protein Sci., 34, 2025
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9L3V
 | | structure of WEEV strain 71V1658 virus-like particle(3-fold region) | | Descriptor: | Structural polyprotein | | Authors: | Liang, S, Yang, Y, Liu, Y, Rao, Z, Wang, Y, Lou, Z. | | Deposit date: | 2024-12-19 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | Structural basis for engagement of Western Equine Encephalitis Virus with the PCDH10 receptor.
Nat Commun, 16, 2025
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9L41
 | | Structure of WEEV strain 71V1658 virus-like particles (VLPs) in complex with human PCDH10 extracellular cadherin repeats 1-2 (EC1-EC2)(3-fold region) | | Descriptor: | Protocadherin-10, Structural polyprotein | | Authors: | Liang, S, Yang, Y, Liu, Y, Rao, Z, Wang, Y, Lou, Z. | | Deposit date: | 2024-12-19 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Structural basis for engagement of Western Equine Encephalitis Virus with the PCDH10 receptor.
Nat Commun, 16, 2025
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9LLQ
 | | Structure of TetR2 and DNA probe | | Descriptor: | DNA (5'-D(P*AP*AP*AP*AP*AP*GP*AP*CP*TP*AP*AP*TP*CP*TP*GP*TP*CP*TP*AP*TP*CP*TP*AP*T)-3'), DNA (5'-D(P*AP*TP*AP*GP*AP*TP*AP*GP*AP*CP*AP*GP*AP*TP*TP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), TetR family transcriptional regulator | | Authors: | He, W, Wen, Y. | | Deposit date: | 2025-01-17 | | Release date: | 2025-08-27 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural and mechanistic insights into the transcriptional regulation of chromosomal T6SS by large conjugative plasmid-encoded TetRs in Acinetobacter baumannii.
Nucleic Acids Res., 53, 2025
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9LMQ
 | | Cryo-EM structure of TIR-STING/c-di-GMP complex | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, CD-NTase-associated protein 12 | | Authors: | Lu, D.F, Liu, S. | | Deposit date: | 2025-01-19 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Structural insights into distinct filamentation states reveal a regulatory mechanism for bacterial STING activation.
Mbio, 2025
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9LMR
 | | Cryo-EM structure of TIR-STING/c-di-GMP complex fiber | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CD-NTase-associated protein 12 | | Authors: | Lu, D.F, Liu, S. | | Deposit date: | 2025-01-20 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural insights into distinct filamentation states reveal a regulatory mechanism for bacterial STING activation.
Mbio, 2025
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9M3F
 | | Cryo-EM structure of Rc-o319 RBD/R. cornutus ACE2 complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike glycoprotein | | Authors: | Matsumoto, K, Shihoya, W, Nureki, O. | | Deposit date: | 2025-03-02 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (2.79 Å) | | Cite: | Molecular basis of sarbecovirus evolution and receptor tropism in natural hosts, potential intermediate hosts, and humans.
Cell Rep, 2025
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9M4F
 | | Photosystem I from the eukaryotic filamentous algae | | Descriptor: | (1~{R},3~{S})-6-[(3~{E},5~{E},7~{E},9~{E},11~{E},13~{E},15~{Z},17~{E})-16-(hydroxymethyl)-3,7,12-trimethyl-18-[(1~{S},4~{S},6~{R})-2,2,6-trimethyl-4-oxidanyl-7-oxabicyclo[4.1.0]heptan-1-yl]octadeca-1,3,5,7,9,11,13,15,17-nonaenylidene]-1,5,5-trimethyl-cyclohexane-1,3-diol, (3S,3'R,5R,6S,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | | Authors: | Shao, R.Q, Pan, X.W. | | Deposit date: | 2025-03-04 | | Release date: | 2025-08-27 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | Architecture of photosystem I-light-harvesting complex from the eukaryotic filamentous yellow-green alga Tribonema minus.
J Integr Plant Biol, 2025
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9M5S
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