8UG4
 
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8UG5
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8UG6
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8UG7
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8UG8
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8UGA
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8UHW
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8UIB
 | | Structure of the human INTS9-INTS11-BRAT1 complex | | Descriptor: | BRCA1-associated ATM activator 1, Integrator complex subunit 11, Integrator complex subunit 9, ... | | Authors: | Lin, M, Tong, L. | | Deposit date: | 2023-10-10 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.
Mol.Cell, 84, 2024
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8UIC
 | | Structure of the Drosophila IntS11-CG7044(dBRAT1) complex | | Descriptor: | FI02071p, Integrator complex subunit 11, ZINC ION | | Authors: | Lin, M, Tong, L. | | Deposit date: | 2023-10-10 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.
Mol.Cell, 84, 2024
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8UPX
 | | Omicron-S-MERS-RBD | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,SARS-CoV-2 omicron spike with MERS RBD | | Authors: | Bu, F, Li, F, Liu, B. | | Deposit date: | 2023-10-23 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Pan-beta-coronavirus subunit vaccine prevents SARS-CoV-2 Omicron, SARS-CoV, and MERS-CoV challenge.
J.Virol., 2024
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8UR8
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8UV2
 | | Human p97/VCP structure with a triazole inhibitor (NSC799462/hexamer) | | Descriptor: | 3-(2,6-difluoro-4-{[(4P)-5-{[(2S)-hexan-2-yl]sulfanyl}-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | | Deposit date: | 2023-11-02 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.
Commun Chem, 7, 2024
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8UVO
 | | Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, N-[3-(2,5-difluoro-4-{[(4M)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide, Transitional endoplasmic reticulum ATPase | | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | | Deposit date: | 2023-11-03 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.22 Å) | | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.
Commun Chem, 7, 2024
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8UVP
 | | Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC819701/up) | | Descriptor: | 2-[(4P)-4-(4-{[(4P)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2H-1,2,3-triazol-2-yl]-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-one, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | | Deposit date: | 2023-11-03 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.
Commun Chem, 7, 2024
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8UVQ
 | | Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC819701/down) | | Descriptor: | 2-[(4P)-4-(4-{[(4P)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2H-1,2,3-triazol-2-yl]-1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]ethan-1-one, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | | Deposit date: | 2023-11-03 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.
Commun Chem, 7, 2024
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8UZT
 | | Mitochondrial single-stranded binding protein bound to DNA | | Descriptor: | GLYCEROL, SODIUM ION, Single-stranded DNA-binding protein, ... | | Authors: | Riccio, A.A, Pedersen, L.C, Bouvette, J, Borgnia, J.M, Copeland, W.C. | | Deposit date: | 2023-11-16 | | Release date: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structures of the mitochondrial single-stranded DNA binding protein with DNA and DNA polymerase gamma.
Nucleic Acids Res., 2024
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8V5C
 | | IpaD (122-321) Bound to Deoxycholate | | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCEROL, Invasin IpaD | | Authors: | Barker, S.A, Dickenson, N.E, Johnson, S.J. | | Deposit date: | 2023-11-30 | | Release date: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Structural and functional characterization of the IpaD pi-helix reveals critical roles in DOC interaction, T3SS apparatus maturation, and Shigella virulence.
J.Biol.Chem., 2024
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8V5E
 | | IpaD (122-321) Pi-helix Mutant (delta Q148) Bound to Deoxycholate | | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCEROL, Invasin IpaD | | Authors: | Barker, S.A, Dickenson, N.E, Johnson, S.J. | | Deposit date: | 2023-11-30 | | Release date: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural and functional characterization of the IpaD pi-helix reveals critical roles in DOC interaction, T3SS apparatus maturation, and Shigella virulence.
J.Biol.Chem., 2024
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8V7Q
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8V7S
 | | IpaD (122-321) Apo Structure | | Descriptor: | Invasin IpaD | | Authors: | Barker, S.A, Dickenson, N.E, Johnson, S.J, Morales, Y. | | Deposit date: | 2023-12-04 | | Release date: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.708 Å) | | Cite: | Structural and functional characterization of the IpaD pi-helix reveals critical roles in DOC interaction, T3SS apparatus maturation, and Shigella virulence.
J.Biol.Chem., 2024
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8VJU
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8VJV
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8VJW
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8VJX
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8VJY
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