9I5P
 
 | | Recombinant human butyrylcholinesterase in complex with 1-(isobutylmethyl)-5-(2,4-difluorobenzyl)-N-(2-(dimethylamino)ethyl)-1H-indazole-6-carboxamide | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Brazzolotto, X, Ferjancic Benetik, S, Knez, D, Proj, M, Gobec, S, Nachon, F. | | Deposit date: | 2025-01-28 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38 alpha Mitogen-Activated Protein Kinase Inhibitors.
J.Med.Chem., 2025
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9I5Q
 | | Recombinant human butyrylcholinesterase in complex with 2-(cyclohexylmethyl)-5-(2,4-difluorophenoxy)-N-(2-(3-(methoxymethyl)piperidin-1-yl)ethyl)-2H-indazole-6-carboxamide | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Brazzolotto, X, Ferjancic Benetik, S, Knez, D, Proj, M, Gobec, S, Nachon, F. | | Deposit date: | 2025-01-28 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38 alpha Mitogen-Activated Protein Kinase Inhibitors.
J.Med.Chem., 2025
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9I5T
 | | 50S subunit of P. gingivalis ribosome with Lefamulin | | Descriptor: | 23S rRNA, 5S rRNA, DUF4295 domain-containing protein, ... | | Authors: | Hiregange, D.G, Bashan, A, Yonath, A. | | Deposit date: | 2025-01-28 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structural studies of ribosome from an anaerobic Bacteroidetes human pathogen Porphyromonas gingivalis.
Nucleic Acids Res., 53, 2025
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9I5V
 | | 70S P. gingivalis ribosome erm-delta-porN strain | | Descriptor: | 16S rRNA, 23S rRNA, 5S rRNA, ... | | Authors: | Hiregange, D.G, Bashan, A, Yonath, A. | | Deposit date: | 2025-01-28 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural studies of ribosome from an anaerobic Bacteroidetes human pathogen Porphyromonas gingivalis.
Nucleic Acids Res., 53, 2025
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9I5X
 | | Porphyromonas gingivalis 70S ribosome (W83 Strain) | | Descriptor: | 16S rRNA, 23S rRNA, 5S rRNA, ... | | Authors: | Hiregange, D.G, Bashan, A, Yonath, A. | | Deposit date: | 2025-01-28 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural studies of ribosome from an anaerobic Bacteroidetes human pathogen Porphyromonas gingivalis.
Nucleic Acids Res., 53, 2025
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9IBE
 | | D-2-hydroxyacid dehydrogenase (D2HDH) from Haloferax mediterranei in complex with potassium, 2-ketohexanoic acid, NADP+ and chloride | | Descriptor: | 2-Ketohexanoic acid, CHLORIDE ION, D-2-hydroxyacid dehydrogenase, ... | | Authors: | Baker, P.J, Barrett, J.R, Dakhil, A.A.A.B, Domenech, J, Bisson, C, Pramanpol, N, Ferrer, J, Rice, D.W. | | Deposit date: | 2025-02-12 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (1.26 Å) | | Cite: | Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase.
Commun Biol, 8, 2025
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9IMK
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9IMM
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9IRB
 | | CryoEM structure of hSLC15A4+Fab107 | | Descriptor: | Fab107 heavy chain, Fab107 light chain, Solute carrier family 15 member 4 | | Authors: | Zhu, Y.L, Zhang, Q.X, Gao, P. | | Deposit date: | 2024-07-15 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Development of conformation-selective antibodies targeting human SLC15A4.
Nat Commun, 16, 2025
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9IRC
 | | CyroEM structure of hSLC15A4+TASL+Fab235 | | Descriptor: | Fab235 heavy chain, Fab235 light chain, Solute carrier family 15 member 4, ... | | Authors: | Zhu, Y.L, Zhang, Q.X, Gao, P. | | Deposit date: | 2024-07-15 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | Development of conformation-selective antibodies targeting human SLC15A4.
Nat Commun, 16, 2025
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9IT2
 | | Cryo-EM structure of urease from Ureaplasma parvum | | Descriptor: | BETA-MERCAPTOETHANOL, NICKEL (II) ION, Urease subunit alpha, ... | | Authors: | Fujita, J, Namba, K, Wu, H.N, Yanagihara, I. | | Deposit date: | 2024-07-19 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.03 Å) | | Cite: | Structural Analysis and Molecular Dynamics Simulations of Urease From Ureaplasma parvum.
J.Mol.Biol., 437, 2025
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9ITH
 | | Nav1.5 in complex with TTX | | Descriptor: | (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Yan, N, Li, Z, Wu, T. | | Deposit date: | 2024-07-20 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Critical role of extracellular loops in differential modulations of TTX-sensitive and TTX-resistant Na v channels.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9ITI
 | | Nav1.7 with mutations that eliminate beta1 binding | | Descriptor: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | Authors: | Yan, N, Li, Z, Wu, T. | | Deposit date: | 2024-07-20 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Critical role of extracellular loops in differential modulations of TTX-sensitive and TTX-resistant Na v channels.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9J5U
 | | Cryo-EM structure of Bat SARS-like coronavirus Khosta-2 spike protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | | Authors: | Pan, X.Q, Li, L.J, Liu, K.F, Qi, J.X, Gao, G.F. | | Deposit date: | 2024-08-13 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.25 Å) | | Cite: | Structural basis of receptor recognition by Khosta-1/Khosta-2 spike proteins
To Be Published
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9J62
 | | Cryo-EM structure of Bat SARS-like coronavirus Khosta-2 spike protein in complex with human ACE2 (local refined) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein, ... | | Authors: | Pan, X.Q, Li, L.J, Liu, K.F, Qi, J.X, Gao, G.F. | | Deposit date: | 2024-08-14 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Structural basis of receptor recognition by Khosta-1/Khosta-2 spike proteins
To Be Published
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9J6E
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9J6G
 | | Cryo-EM structure of Bat SARS-like coronavirus Khosta-1 spike protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | Authors: | Pan, X.Q, Li, L.J, Liu, K.F, Qi, J.X, Gao, G.F. | | Deposit date: | 2024-08-15 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structural basis of receptor recognition by Khosta-1/Khosta-2 spike proteins
To Be Published
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9J6L
 | | Solution structure of human Glutathione Peroxidase 4 (Sec73Cys) with eight mutations | | Descriptor: | Phospholipid hydroperoxide glutathione peroxidase GPX4 | | Authors: | Furuita, K, Sugiki, T, Inomata, K, Miyanoiri, Y, Kobayashi, N, Fujiwara, T, Kojima, C. | | Deposit date: | 2024-08-16 | | Release date: | 2025-08-20 | | Method: | SOLUTION NMR | | Cite: | Glutathione Disulfide Acts as a Feedback Inhibitor of GPx4 Redox Reaction through Allosteric Regulation
To Be Published
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9JF7
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9JJ8
 | | Structural insights into the PSI-FCPI supercomplex from the coccolithophore Emiliania huxleyi | | Descriptor: | (3S,3'R,5R,6S,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol, (3S,3'S,5R,5'R,6S,6'R,8'R)-3,5'-dihydroxy-8-oxo-6',7'-didehydro-5,5',6,6',7,8-hexahydro-5,6-epoxy-beta,beta-caroten-3'- yl acetate, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ... | | Authors: | Shen, L.L, Li, Z.H, Wang, W.D. | | Deposit date: | 2024-09-13 | | Release date: | 2025-08-20 | | Method: | ELECTRON MICROSCOPY (2.79 Å) | | Cite: | Structural insights into the PSI-FCPI supercomplex from the coccolithophore Emiliania huxleyi
To Be Published
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9JPE
 | | the DISMED2 domain of RetS | | Descriptor: | Noradrenaline, histidine kinase | | Authors: | Wang, C.C. | | Deposit date: | 2024-09-26 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | crystal structure of the DISMED2 domain of RetS at 3.5 Angstrom resolution
To Be Published
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9JSY
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9JTT
 | | Crystal Structure of Beta-glucosidase from the Indigo-producing Plant Polygonum tinctorium | | Descriptor: | 1,2-ETHANEDIOL, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | Authors: | Yoneda, K, Himeno, M, Sakuraba, H, Ohshima, T. | | Deposit date: | 2024-10-07 | | Release date: | 2025-08-20 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Crystal Structure of Beta-glucosidase from the Indigo-producing Plant Polygonum tinctorium
To Be Published
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9K0C
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9K0N
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