9PH4
 
 | | Cryo-EM structure of COP9 signalosome in complex with CSN5i-1a | | Descriptor: | 6-[(4R,5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1'-biphenyl]-3-carbonitrile, COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, ... | | Authors: | Shi, H, Zheng, N. | | Deposit date: | 2025-07-08 | | Release date: | 2025-12-03 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structure of COP9 signalosome in complex with CSN5i-1a
To Be Published
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9PHL
 | | [A4J-A] Asymmetric tensegrity triangle containing a semi-junction formed via in crystallo hybridization | | Descriptor: | DNA (5'-D(*AP*AP*CP*CP*TP*AP*CP*CP*TP*GP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*T)-3'), DNA (5'-D(*CP*AP*GP*AP*TP*AP*CP*CP*TP*GP*AP*TP*CP*GP*GP*AP*CP*TP*AP*CP*G)-3'), DNA (5'-D(*GP*AP*GP*CP*GP*AP*CP*CP*TP*GP*TP*AP*CP*GP*GP*AP*CP*AP*TP*CP*A)-3'), ... | | Authors: | Horvath, A, Wang, M, Woloszyn, K, Vecchioni, S, Ohayon, Y.P, Sha, R. | | Deposit date: | 2025-07-09 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (6.25 Å) | | Cite: | Single Stranded Regions in Tensegrity Triangles
To Be Published
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9PMD
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9PWO
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9PZ5
 | | Native anti-NANP Fab | | Descriptor: | IgG heavy chain, IgG lambda light chain | | Authors: | Young, T. | | Deposit date: | 2025-08-08 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Single-residue engineering of lambda ( lambda ) antibody light chains reduces conformational flexibility and enhances thermal stability.
Comput Struct Biotechnol J, 27, 2025
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9PZ6
 | | Anti-NANP Fab with G112T light chain mutation | | Descriptor: | DI(HYDROXYETHYL)ETHER, IgG heavy chain, IgG light chain, ... | | Authors: | Young, T. | | Deposit date: | 2025-08-08 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Single-residue engineering of lambda ( lambda ) antibody light chains reduces conformational flexibility and enhances thermal stability.
Comput Struct Biotechnol J, 27, 2025
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9Q0P
 | | Human anti-EBV gH/gL Fab (AMMO1) with G111T light chain mutation | | Descriptor: | GLYCEROL, IgG heavy chain, IgG lambda light chain | | Authors: | Young, T. | | Deposit date: | 2025-08-13 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Single-residue engineering of lambda ( lambda ) antibody light chains reduces conformational flexibility and enhances thermal stability.
Comput Struct Biotechnol J, 27, 2025
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9Q5J
 | | [12-5B G|A] 12 bp tensegrity triangle that propagates via blunt-end stacking with G stacking on A at the interface | | Descriptor: | DNA (5'-D(P*AP*GP*GP*AP*CP*TP*A)-3'), DNA (5'-D(P*CP*AP*CP*CP*T)-3'), DNA (5'-D(P*GP*TP*CP*TP*G)-3'), ... | | Authors: | Horvath, A, Woloszyn, K, Vecchioni, S, Ohayon, Y.P, Sha, R. | | Deposit date: | 2025-08-20 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Blunt-End Tensegrity Triangles
To Be Published
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9Q8Z
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9QD7
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 15a | | Descriptor: | (2~{S},9~{S})-2-cyclohexyl-19,22-dimethoxy-11,14,17-trioxa-4-azatricyclo[16.2.2.0^{4,9}]docosa-1(21),18(22),19-triene-3,10-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Brudy, C, Hausch, F. | | Deposit date: | 2025-03-06 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2.264 Å) | | Cite: | Linker Modification Enables Control of Key Functional Group Orientation in Macrocycles.
J.Med.Chem., 2025
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9QD8
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 29a | | Descriptor: | (2~{S},9~{S},12~{S})-2-cyclohexyl-19,22-dimethoxy-12-methyl-11,14,17-trioxa-4-azatricyclo[16.2.2.0^{4,9}]docosa-1(21),18(22),19-triene-3,10-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Brudy, C, Hausch, F. | | Deposit date: | 2025-03-06 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Linker Modification Enables Control of Key Functional Group Orientation in Macrocycles.
J.Med.Chem., 2025
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9QD9
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 29c | | Descriptor: | (2~{S},9~{S},12~{S})-2-cyclohexyl-20,23-dimethoxy-12-methyl-11,14,18-trioxa-4-azatricyclo[17.2.2.0^{4,9}]tricosa-1(22),19(23),20-triene-3,10-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Brudy, C, Hausch, F. | | Deposit date: | 2025-03-06 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Linker Modification Enables Control of Key Functional Group Orientation in Macrocycles.
J.Med.Chem., 2025
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9QDA
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 29b | | Descriptor: | (2~{S},9~{S},12~{R})-2-cyclohexyl-19,22-dimethoxy-12-methyl-11,14,17-trioxa-4-azatricyclo[16.2.2.0^{4,9}]docosa-1(21),18(22),19-triene-3,10-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Brudy, C, Hausch, F. | | Deposit date: | 2025-03-06 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Linker Modification Enables Control of Key Functional Group Orientation in Macrocycles.
J.Med.Chem., 2025
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9QDB
 | | The FK1 domain of FKBP51 in complex with the macrocyclic SAFit analog 29d | | Descriptor: | (2~{S},9~{S},12~{R})-2-cyclohexyl-20,23-dimethoxy-12-methyl-11,14,18-trioxa-4-azatricyclo[17.2.2.0^{4,9}]tricosa-1(22),19(23),20-triene-3,10-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | | Authors: | Meyners, C, Brudy, C, Hausch, F. | | Deposit date: | 2025-03-06 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Linker Modification Enables Control of Key Functional Group Orientation in Macrocycles.
J.Med.Chem., 2025
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9QFI
 | | Crystal structure of YTHDF2 in complex with compound 6 (AI-DF2-47) | | Descriptor: | 3-methyl-1~{H}-pyrazolo[3,4-d]pyrimidin-4-amine, CHLORIDE ION, GLYCEROL, ... | | Authors: | Nai, F, Invernizzi, A, Caflisch, A. | | Deposit date: | 2025-03-11 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Discovery of YTHDF2 Ligands by Fragment-Based Design.
Acs Bio Med Chem Au, 5, 2025
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9QGZ
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9QIT
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9QN8
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9QNA
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9QNB
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9QNC
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9QR4
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9QS9
 | | Structure and mechanism of the broad spectrum CRISPR-associated ring nuclease Crn4 | | Descriptor: | Crn4 H15A, Cyclic polyA, MAGNESIUM ION | | Authors: | McMahon, S.A, Chi, H, Hoikkala, V, Gloster, T.M, White, M.F. | | Deposit date: | 2025-04-04 | | Release date: | 2025-12-03 | | Method: | X-RAY DIFFRACTION (1.441 Å) | | Cite: | Structure and mechanism of the broad spectrum CRISPR-associated ring nuclease Crn4
To Be Published
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9QUX
 | | Solution structure of the Homer1 EVH1 domain | | Descriptor: | Homer protein homolog 1 | | Authors: | Czajlik, A, Maruzs, B, Fanni, F, Batta, G, Gaspari, Z, Peterfia, B.F. | | Deposit date: | 2025-04-11 | | Release date: | 2025-12-03 | | Method: | SOLUTION NMR | | Cite: | Structural Modeling and Dynamics of the Full-Length Homer1 Multimer.
Proteins, 2025
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9QWN
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