9D0U
 
 | | Crystal structure of CDK2 in complex with Cpd 2 | | Descriptor: | 6-chloro-8-cyclopentyl-2-[4-(ethanesulfonyl)-2-methylanilino]pyrido[2,3-d]pyrimidin-7(8H)-one, Cyclin-dependent kinase 2 | | Authors: | Kwiatkowski, N, Liang, T, Sha, Z, Collier, P.N, Yang, A, Sathappa, M, Paul, A, Su, L, Zheng, X, Aversa, R, Li, K, Mehovic, R, Breitkopf, S.B, Chen, D, Howarth, C.L, Yuan, K, Jo, H, Growney, J.D, Weiss, M, Williams, J. | | Deposit date: | 2024-08-07 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
Cell Chem Biol, 32, 2025
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9D0V
 | | Crystal structure of CDK2/CyclinE1 in complex with Cpd 2 | | Descriptor: | 1,2-ETHANEDIOL, 6-chloro-8-cyclopentyl-2-[4-(ethanesulfonyl)-2-methylanilino]pyrido[2,3-d]pyrimidin-7(8H)-one, Cyclin-dependent kinase 2, ... | | Authors: | Kwiatkowski, N, Liang, T, Sha, Z, Collier, P.N, Yang, A, Sathappa, M, Paul, A, Su, L, Zheng, X, Aversa, R, Li, K, Mehovic, R, Breitkopf, S.B, Chen, D, Howarth, C.L, Yuan, K, Jo, H, Growney, J.D, Weiss, M, Williams, J. | | Deposit date: | 2024-08-07 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
Cell Chem Biol, 32, 2025
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9D0W
 | | Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 4 | | Descriptor: | (3R)-3-(5-{4-[(2-{4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]-3-methylbenzene-1-sulfonyl}-7-azaspiro[3.5]nonan-7-yl)methyl]piperidin-1-yl}-4-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidine-2,6-dione, Cyclin-dependent kinase 2, DNA damage-binding protein 1, ... | | Authors: | Kwiatkowski, N, Liang, T, Sha, Z, Collier, P.N, Yang, A, Sathappa, M, Paul, A, Su, L, Zheng, X, Aversa, R, Li, K, Mehovic, R, Breitkopf, S.B, Chen, D, Howarth, C.L, Yuan, K, Jo, H, Growney, J.D, Weiss, M, Williams, J. | | Deposit date: | 2024-08-07 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
Cell Chem Biol, 32, 2025
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9D0X
 | | Cryo-EM structure of CDK2/CyclinE1 in complex with CRBN/DDB1 and Cpd 4 (local mask) | | Descriptor: | (3R)-3-(5-{4-[(2-{4-[(8-cyclopentyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]-3-methylbenzene-1-sulfonyl}-7-azaspiro[3.5]nonan-7-yl)methyl]piperidin-1-yl}-4-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidine-2,6-dione, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, ... | | Authors: | Kwiatkowski, N, Liang, T, Sha, Z, Collier, P.N, Yang, A, Sathappa, M, Paul, A, Su, L, Zheng, X, Aversa, R, Li, K, Mehovic, R, Breitkopf, S.B, Chen, D, Howarth, C.L, Yuan, K, Jo, H, Growney, J.D, Weiss, M, Williams, J. | | Deposit date: | 2024-08-07 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers
Cell Chem Biol, 32, 2025
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9D17
 | | Crystal structure of the catalytic region of human MASP-2 with specific inhibitor Compound S1 | | Descriptor: | 2-(2-amino-1H-1,3-benzimidazol-1-yl)-N-(5-ethylpyridin-2-yl)acetamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | | Authors: | Sawyer, T.K, Wibowo, A.S, Carter, J, Moussa, S.H. | | Deposit date: | 2024-08-07 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3.
Eur.J.Med.Chem., 289, 2025
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9D3Y
 | | Crystal structure of the catalytic region of human MASP-2 with specific inhibitor Compound S2 | | Descriptor: | (2S)-N-[2-(2-amino-1H-1,3-benzimidazol-5-yl)ethyl]-1-[(2R,4S)-4-phenylpiperidine-2-carbonyl]azetidine-2-carboxamide, GLYCEROL, Mannan-binding lectin serine protease 2 B chain | | Authors: | Sawyer, T.K, Wibowo, A.S, Carter, J, Moussa, S.H. | | Deposit date: | 2024-08-12 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3.
Eur.J.Med.Chem., 289, 2025
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9D40
 | | Crystal structure of the catalytic region of human MASP-2 with specific inhibitor Analog 20 | | Descriptor: | GLYCEROL, Mannan-binding lectin serine protease 2 B chain, N-{[4-(2-amino-1H-imidazol-4-yl)phenyl]methyl}-2-[4-(benzenesulfonamido)phenyl]acetamide | | Authors: | Sawyer, T.K, Wibowo, A.S, Carter, J, Moussa, S.H. | | Deposit date: | 2024-08-12 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3.
Eur.J.Med.Chem., 289, 2025
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9D4D
 | | Crystal structure of the catalytic region of human MASP-2 with specific inhibitor Compound S3 | | Descriptor: | 2-(2-amino-1H-1,3-benzimidazol-4-yl)-N-{4-[(pyridin-4-yl)methyl]phenyl}acetamide, GLYCEROL, Mannan-binding lectin serine protease 2 B chain | | Authors: | Sawyer, T.K, Wibowo, A.S, Carter, J, Moussa, S.H. | | Deposit date: | 2024-08-12 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3.
Eur.J.Med.Chem., 289, 2025
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9DFG
 | | Crystal structure of PrnB in complex with 7-Cl-Trp | | Descriptor: | 7-CHLOROTRYPTOPHAN, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Li, B, Wang, Y. | | Deposit date: | 2024-08-30 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Elucidating ligand interactions and small-molecule activation in the pyrrolnitrin biosynthetic enzyme PrnB.
J.Biol.Chem., 301, 2025
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9DFI
 | | Crystal structure of PrnB in complex with Tryptophan | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Li, B, Wang, Y. | | Deposit date: | 2024-08-30 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Elucidating ligand interactions and small-molecule activation in the pyrrolnitrin biosynthetic enzyme PrnB.
J.Biol.Chem., 301, 2025
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9DFL
 | | Crystal structure of PrnB in complex with 3-indolepropionic acid | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, INDOLYLPROPIONIC ACID, ... | | Authors: | Li, B, Wang, Y. | | Deposit date: | 2024-08-30 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Elucidating ligand interactions and small-molecule activation in the pyrrolnitrin biosynthetic enzyme PrnB.
J.Biol.Chem., 301, 2025
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9DFM
 | | Crystal structure of PrnB in complex with tryptamine | | Descriptor: | 2-(1H-INDOL-3-YL)ETHANAMINE, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Li, B, Wang, Y. | | Deposit date: | 2024-08-30 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Elucidating ligand interactions and small-molecule activation in the pyrrolnitrin biosynthetic enzyme PrnB.
J.Biol.Chem., 301, 2025
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9DHY
 | | Structure of SARS-CoV-2 spike in complex with antibody Fab COVIC-154 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab COVIC-154 Heavy Chain, ... | | Authors: | Yu, X, Saphire, E.O. | | Deposit date: | 2024-09-04 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein.
Cell Rep, 44, 2025
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9DIN
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9DQI
 | | D306N Mutant of M.tuberculosis MenD (SEPHCHC Synthase) | | Descriptor: | 1,2-ETHANEDIOL, 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ... | | Authors: | Johnston, J.M, Ho, N.A.T, Given, F.M, Bulloch, E.M.M, Allison, T.M, Jiao, W. | | Deposit date: | 2024-09-24 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Apparent Reversal of Allosteric Response in Mycobacterium tuberculosis MenD Reveals Links to Half-of-Sites Reactivity.
Chembiochem, 2025
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9DSN
 | | D306A Mutant of M.tuberculosis MenD (SEPHCHC Synthase) | | Descriptor: | 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, CHLORIDE ION, ... | | Authors: | Johnston, J.M, Ho, N.A.T, Given, F.M, Allison, T.A, Bulloch, E.M.M, Jiao, W. | | Deposit date: | 2024-09-28 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Apparent Reversal of Allosteric Response in Mycobacterium tuberculosis MenD Reveals Links to Half-of-Sites Reactivity.
Chembiochem, 2025
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9DSO
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9DTV
 | | Structure of D141A mutant of M.tuberculosis MenD (SEPHCHC Synthase) | | Descriptor: | 1,2-ETHANEDIOL, 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ... | | Authors: | Johnston, J.M, Ho, N.A.T, Given, F.M, Allison, T.M, Bulloch, E.M.M, Jiao, W. | | Deposit date: | 2024-10-02 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Apparent Reversal of Allosteric Response in Mycobacterium tuberculosis MenD Reveals Links to Half-of-Sites Reactivity.
Chembiochem, 2025
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9DU5
 | | Cryo-EM structure of phosphoglucomutase from Thermococcus kodakarensis | | Descriptor: | Phosphoglucomutase/phosphomannomutase | | Authors: | Naz, Z, Rathore, I, Saleem, M, Rahman, M, Rashid, N, Wlodawer, A. | | Deposit date: | 2024-10-02 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.45 Å) | | Cite: | A Bifunctional Phosphoglucomutase/Phosphomannomutase from Thermococcus kodakarensis : Biophysical Analysis and Cryo-EM Structure.
Biomolecules, 15, 2025
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9DWN
 | | hTHIK1 Cryo-EM structure in GDN detergent | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, Potassium channel subfamily K member 13 | | Authors: | Riel, E.B, Riegelhaupt, P.M. | | Deposit date: | 2024-10-09 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | The cryo-EM structure and physical basis for anesthetic inhibition of the THIK1 K2P channel.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9DY7
 | | Proteus vulgaris tryptophan indole-lyase complexed with L-ethionine and Na+ | | Descriptor: | (2E)-4-(ethylsulfanyl)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}butanoic acid, (E)-S-ethyl-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-homocysteine, 1,2-ETHANEDIOL, ... | | Authors: | Phillips, R.S. | | Deposit date: | 2024-10-13 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Structure and dynamics of Proteus vulgaris tryptophan indole-lyase complexes with l-ethionine and l-alanine.
Arch.Biochem.Biophys., 768, 2025
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9E2V
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9EA1
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9ECQ
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9ECR
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