+Open data
-Basic information
Entry | Database: PDB / ID: 5x1w | ||||||
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Title | PKM2 in complex with compound 5 | ||||||
Components | Pyruvate kinase PKM | ||||||
Keywords | TRANSFERASE / activator / complex | ||||||
Function / homology | Function and homology information pyruvate kinase / pyruvate kinase activity / programmed cell death / Pyruvate metabolism / positive regulation of cytoplasmic translation / histone H3T11 kinase activity / canonical glycolysis / Glycolysis / positive regulation of sprouting angiogenesis / potassium ion binding ...pyruvate kinase / pyruvate kinase activity / programmed cell death / Pyruvate metabolism / positive regulation of cytoplasmic translation / histone H3T11 kinase activity / canonical glycolysis / Glycolysis / positive regulation of sprouting angiogenesis / potassium ion binding / rough endoplasmic reticulum / Regulation of pyruvate metabolism / glycolytic process / non-specific protein-tyrosine kinase / cellular response to insulin stimulus / cilium / extracellular vesicle / MHC class II protein complex binding / protein tyrosine kinase activity / secretory granule lumen / collagen-containing extracellular matrix / transcription coactivator activity / vesicle / ficolin-1-rich granule lumen / non-specific serine/threonine protein kinase / cadherin binding / mRNA binding / Neutrophil degranulation / magnesium ion binding / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / mitochondrion / RNA binding / extracellular exosome / extracellular region / ATP binding / nucleus / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 3 Å | ||||||
Authors | Matsui, Y. / Hanzawa, H. | ||||||
Citation | Journal: Bioorg. Med. Chem. / Year: 2017 Title: Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator Authors: Matsui, Y. / Yasumatsu, I. / Asahi, T. / Kitamura, T. / Kanai, K. / Ubukata, O. / Hayasaka, H. / Takaishi, S. / Hanzawa, H. / Katakura, S. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 5x1w.cif.gz | 753.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb5x1w.ent.gz | 627.8 KB | Display | PDB format |
PDBx/mmJSON format | 5x1w.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 5x1w_validation.pdf.gz | 2.3 MB | Display | wwPDB validaton report |
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Full document | 5x1w_full_validation.pdf.gz | 2.4 MB | Display | |
Data in XML | 5x1w_validation.xml.gz | 65.4 KB | Display | |
Data in CIF | 5x1w_validation.cif.gz | 90.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/x1/5x1w ftp://data.pdbj.org/pub/pdb/validation_reports/x1/5x1w | HTTPS FTP |
-Related structure data
Related structure data | 5x1vSC S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Refine code: 5
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