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Yorodumi- PDB-4tgf: SOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DER... -
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-Basic information
Entry | Database: PDB / ID: 4tgf | ||||||
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Title | SOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DERIVED FROM 1*H NMR DATA | ||||||
Components | DES-VAL-1,VAL-2,TRANSFORMING GROWTH FACTOR, ALPHA | ||||||
Keywords | GROWTH FACTOR | ||||||
Function / homology | Function and homology information hepatocyte proliferation / Cargo concentration in the ER / Inhibition of Signaling by Overexpressed EGFR / COPII-mediated vesicle transport / EGFR interacts with phospholipase C-gamma / ERBB2-EGFR signaling pathway / epidermal growth factor receptor binding / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of cell division ...hepatocyte proliferation / Cargo concentration in the ER / Inhibition of Signaling by Overexpressed EGFR / COPII-mediated vesicle transport / EGFR interacts with phospholipase C-gamma / ERBB2-EGFR signaling pathway / epidermal growth factor receptor binding / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of cell division / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / mammary gland alveolus development / GAB1 signalosome / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / endoplasmic reticulum-Golgi intermediate compartment membrane / positive regulation of mitotic nuclear division / positive regulation of epithelial cell proliferation / EGFR downregulation / clathrin-coated endocytic vesicle membrane / growth factor activity / epidermal growth factor receptor signaling pathway / ER to Golgi transport vesicle membrane / Constitutive Signaling by Aberrant PI3K in Cancer / positive regulation of peptidyl-tyrosine phosphorylation / Cargo recognition for clathrin-mediated endocytosis / PIP3 activates AKT signaling / Clathrin-mediated endocytosis / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cytoplasmic vesicle / RAF/MAP kinase cascade / basolateral plasma membrane / angiogenesis / Estrogen-dependent gene expression / Extra-nuclear estrogen signaling / positive regulation of MAPK cascade / receptor ligand activity / intracellular signal transduction / positive regulation of cell population proliferation / endoplasmic reticulum membrane / perinuclear region of cytoplasm / cell surface / extracellular space / extracellular region / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Kline, T.P. / Brown, F.K. / Brown, S.C. / Jeffs, P.W. / Kopple, K.D. / Mueller, L. | ||||||
Citation | Journal: Biochemistry / Year: 1990 Title: Solution structures of human transforming growth factor alpha derived from 1H NMR data. Authors: Kline, T.P. / Brown, F.K. / Brown, S.C. / Jeffs, P.W. / Kopple, K.D. / Mueller, L. #1: Journal: Biochemistry / Year: 1989 Title: 1H NMR Assignment and Secondary Structural Elements of Human Transforming Growth Factor Alpha Authors: Brown, S.C. / Mueller, L. / Jeffs, P.W. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 4tgf.cif.gz | 62.7 KB | Display | PDBx/mmCIF format |
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PDB format | pdb4tgf.ent.gz | 52.3 KB | Display | PDB format |
PDBx/mmJSON format | 4tgf.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/tg/4tgf ftp://data.pdbj.org/pub/pdb/validation_reports/tg/4tgf | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein/peptide | Mass: 5560.246 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P01135 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Processing
NMR software |
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NMR ensemble | Conformers submitted total number: 4 |