+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 4tgf | ||||||
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タイトル | SOLUTION STRUCTURES OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA DERIVED FROM 1*H NMR DATA | ||||||
要素 | DES-VAL-1,VAL-2,TRANSFORMING GROWTH FACTOR, ALPHA | ||||||
キーワード | GROWTH FACTOR (成長因子) | ||||||
機能・相同性 | 機能・相同性情報 hepatocyte proliferation / Cargo concentration in the ER / Inhibition of Signaling by Overexpressed EGFR / COPII-mediated vesicle transport / EGFR interacts with phospholipase C-gamma / ERBB2-EGFR signaling pathway / epidermal growth factor receptor binding / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of cell division ...hepatocyte proliferation / Cargo concentration in the ER / Inhibition of Signaling by Overexpressed EGFR / COPII-mediated vesicle transport / EGFR interacts with phospholipase C-gamma / ERBB2-EGFR signaling pathway / epidermal growth factor receptor binding / Signaling by EGFR / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of cell division / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / mammary gland alveolus development / GAB1 signalosome / GRB2 events in EGFR signaling / SHC1 events in EGFR signaling / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / endoplasmic reticulum-Golgi intermediate compartment membrane / positive regulation of mitotic nuclear division / positive regulation of epithelial cell proliferation / EGFR downregulation / clathrin-coated endocytic vesicle membrane / growth factor activity / epidermal growth factor receptor signaling pathway / ER to Golgi transport vesicle membrane / Constitutive Signaling by Aberrant PI3K in Cancer / positive regulation of peptidyl-tyrosine phosphorylation / Cargo recognition for clathrin-mediated endocytosis / PIP3 activates AKT signaling / Clathrin-mediated endocytosis / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / cytoplasmic vesicle / RAF/MAP kinase cascade / basolateral plasma membrane / 血管新生 / Estrogen-dependent gene expression / Extra-nuclear estrogen signaling / positive regulation of MAPK cascade / receptor ligand activity / intracellular signal transduction / positive regulation of cell population proliferation / endoplasmic reticulum membrane / perinuclear region of cytoplasm / 細胞膜 / extracellular space / extracellular region / 細胞膜 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 溶液NMR | ||||||
データ登録者 | Kline, T.P. / Brown, F.K. / Brown, S.C. / Jeffs, P.W. / Kopple, K.D. / Mueller, L. | ||||||
引用 | ジャーナル: Biochemistry / 年: 1990 タイトル: Solution structures of human transforming growth factor alpha derived from 1H NMR data. 著者: Kline, T.P. / Brown, F.K. / Brown, S.C. / Jeffs, P.W. / Kopple, K.D. / Mueller, L. #1: ジャーナル: Biochemistry / 年: 1989 タイトル: 1H NMR Assignment and Secondary Structural Elements of Human Transforming Growth Factor Alpha 著者: Brown, S.C. / Mueller, L. / Jeffs, P.W. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 4tgf.cif.gz | 62.7 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb4tgf.ent.gz | 52.3 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 4tgf.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/tg/4tgf ftp://data.pdbj.org/pub/pdb/validation_reports/tg/4tgf | HTTPS FTP |
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-関連構造データ
-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質・ペプチド | 分子量: 5560.246 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 参照: UniProt: P01135 |
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-実験情報
-実験
実験 | 手法: 溶液NMR |
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-解析
NMR software |
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NMRアンサンブル | 登録したコンフォーマーの数: 4 |