Entry | Database: PDB / ID: 4f4o |
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Title | Structure of the Haptoglobin-Haemoglobin Complex |
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Components | - (Hemoglobin subunit ...) x 2
- Haptoglobin
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Keywords | OXYGEN TRANSPORT/TRANSPORT PROTEIN / Globin Fold / Serine Protease Fold / Complement Control Protein / Haemoglobin scavenging / OXYGEN STORAGE-TRANSPORT complex / OXYGEN TRANSPORT-TRANSPORT PROTEIN complex |
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Function / homology | Function and homology information
Scavenging of heme from plasma / : / acute inflammatory response / Neutrophil degranulation / zymogen activation / cellular oxidant detoxification / immune system process / hemoglobin binding / hemoglobin alpha binding / haptoglobin-hemoglobin complex ...Scavenging of heme from plasma / : / acute inflammatory response / Neutrophil degranulation / zymogen activation / cellular oxidant detoxification / immune system process / hemoglobin binding / hemoglobin alpha binding / haptoglobin-hemoglobin complex / organic acid binding / hemoglobin complex / antioxidant activity / acute-phase response / hydrogen peroxide catabolic process / oxygen carrier activity / oxygen binding / defense response to bacterium / iron ion binding / serine-type endopeptidase activity / heme binding / extracellular space / metal ion bindingSimilarity search - Function Haptoglobin / Complement Module, domain 1 / Complement Module; domain 1 / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / : / Hemoglobin, pi / Hemoglobin, alpha-type / Hemoglobin, beta-type ...Haptoglobin / Complement Module, domain 1 / Complement Module; domain 1 / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / : / Hemoglobin, pi / Hemoglobin, alpha-type / Hemoglobin, beta-type / Globin/Protoglobin / Globins / Globin domain profile. / Globin-like / Globin / Globin / Globin-like superfamily / Ribbon / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Orthogonal Bundle / Mainly Beta / Mainly AlphaSimilarity search - Domain/homology PROTOPORPHYRIN IX CONTAINING FE / OXYGEN MOLECULE / Hemoglobin subunit alpha / Hemoglobin subunit beta / HaptoglobinSimilarity search - Component |
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Biological species | Sus scrofa (pig) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.9 Å |
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Authors | Andersen, C.B.F. / Torvund-Jensen, M. / Nielsen, M.J. / Oliveira, C.L.P. / Hersleth, H.P. / Andersen, N.H. / Pedersen, J.S. / Andersen, G.R. / Moestrup, S.K. |
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Citation | Journal: Nature / Year: 2012 Title: Structure of the haptoglobin-haemoglobin complex. Authors: Andersen, C.B. / Torvund-Jensen, M. / Nielsen, M.J. / de Oliveira, C.L. / Hersleth, H.P. / Andersen, N.H. / Pedersen, J.S. / Andersen, G.R. / Moestrup, S.K. |
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History | Deposition | May 11, 2012 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 29, 2012 | Provider: repository / Type: Initial release |
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Revision 1.1 | Sep 26, 2012 | Group: Database references |
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Revision 2.0 | Jul 29, 2020 | Group: Atomic model / Data collection ...Atomic model / Data collection / Derived calculations / Source and taxonomy / Structure summary Category: atom_site / atom_site_anisotrop ...atom_site / atom_site_anisotrop / chem_comp / entity / entity_src_nat / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _atom_site_anisotrop.U[1][1] / _atom_site_anisotrop.U[1][2] / _atom_site_anisotrop.U[1][3] / _atom_site_anisotrop.U[2][2] / _atom_site_anisotrop.U[2][3] / _atom_site_anisotrop.U[3][3] / _atom_site_anisotrop.pdbx_auth_asym_id / _atom_site_anisotrop.pdbx_auth_atom_id / _atom_site_anisotrop.pdbx_auth_comp_id / _atom_site_anisotrop.pdbx_auth_seq_id / _atom_site_anisotrop.pdbx_label_asym_id / _atom_site_anisotrop.pdbx_label_atom_id / _atom_site_anisotrop.pdbx_label_comp_id / _atom_site_anisotrop.type_symbol / _chem_comp.name / _chem_comp.type / _entity_src_nat.entity_id / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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Revision 2.1 | Sep 13, 2023 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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Revision 2.2 | Mar 13, 2024 | Group: Source and taxonomy / Structure summary / Category: entity / entity_src_nat / Item: _entity.details |
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