positive regulation of shelterin complex assembly / negative regulation of establishment of protein localization to telomere / negative regulation of establishment of RNA localization to telomere / negative regulation of establishment of protein-containing complex localization to telomere / negative regulation of telomere maintenance via semi-conservative replication / negative regulation of exonuclease activity / negative regulation of telomeric D-loop disassembly / positive regulation of protein polyubiquitination / meiotic telomere clustering / t-circle formation ...positive regulation of shelterin complex assembly / negative regulation of establishment of protein localization to telomere / negative regulation of establishment of RNA localization to telomere / negative regulation of establishment of protein-containing complex localization to telomere / negative regulation of telomere maintenance via semi-conservative replication / negative regulation of exonuclease activity / negative regulation of telomeric D-loop disassembly / positive regulation of protein polyubiquitination / meiotic telomere clustering / t-circle formation / telomeric D-loop disassembly / common myeloid progenitor cell proliferation / shelterin complex / Telomere C-strand synthesis initiation / double-stranded telomeric DNA binding / Telomere C-strand (Lagging Strand) Synthesis / : / regulation of DNA damage checkpoint / positive regulation of telomere maintenance / nuclear telomere cap complex / ankyrin repeat binding / cellular homeostasis / Processive synthesis on the C-strand of the telomere / Polymerase switching on the C-strand of the telomere / Removal of the Flap Intermediate from the C-strand / G-rich strand telomeric DNA binding / telomere capping / Telomere Extension By Telomerase / negative regulation of protein localization to nucleus / DNA binding, bending / SCF ubiquitin ligase complex / negative regulation of telomere maintenance via telomere lengthening / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / post-transcriptional regulation of gene expression / telomeric DNA binding / negative regulation of DNA replication / Association of TriC/CCT with target proteins during biosynthesis / negative regulation of telomere maintenance via telomerase / telomere maintenance via telomerase / ubiquitin-like ligase-substrate adaptor activity / Packaging Of Telomere Ends / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / ubiquitin ligase complex / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / negative regulation of fibroblast proliferation / Meiotic synapsis / Inhibition of DNA recombination at telomere / positive regulation of telomere maintenance via telomerase / telomere maintenance / DNA Damage/Telomere Stress Induced Senescence / positive regulation of protein ubiquitination / cellular response to ionizing radiation / protein destabilization / regulation of protein stability / cellular senescence / fibrillar center / spindle / protein polyubiquitination / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / Neddylation / chromosome, telomeric region / ubiquitin-dependent protein catabolic process / microtubule binding / nuclear body / protein ubiquitination / cell division / nucleolus / protein homodimerization activity / DNA binding / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function
Mass: 18.015 Da / Num. of mol.: 60 / Source method: isolated from a natural source / Formula: H2O
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.67 Å3/Da / Density % sol: 53.9 %
Crystal grow
Temperature: 289 K / Method: vapor diffusion / pH: 6.2 Details: 300 mM NH4H2PO4, 100 mM sodium citrate pH 6.2, 10% n-propanol and 10 mM DTT, VAPOR DIFFUSION, temperature 289K
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