Entry Database : PDB / ID : 1bdy Structure visualization Downloads & linksTitle C2 DOMAIN FROM PROTEIN KINASE C DELTA ComponentsPROTEIN KINASE C Details Keywords CALCIUM-BINDING / PROTEIN KINASE C / C2 DOMAIN / CALCIUM / DUPLICATION / ATP-BINDING / TRANSFERASEFunction / homology Function and homology informationFunction Domain/homology Component
: / interleukin-10 production / interleukin-12 production / DAG and IP3 signaling / positive regulation of phospholipid scramblase activity / CLEC7A (Dectin-1) signaling / HuR (ELAVL1) binds and stabilizes mRNA / : / positive regulation of glucosylceramide catabolic process / Calmodulin induced events ... : / interleukin-10 production / interleukin-12 production / DAG and IP3 signaling / positive regulation of phospholipid scramblase activity / CLEC7A (Dectin-1) signaling / HuR (ELAVL1) binds and stabilizes mRNA / : / positive regulation of glucosylceramide catabolic process / Calmodulin induced events / SHC1 events in ERBB2 signaling / positive regulation of sphingomyelin catabolic process / Role of phospholipids in phagocytosis / diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / Effects of PIP2 hydrolysis / VEGFR2 mediated cell proliferation / TIR domain binding / calcium,diacylglycerol-dependent serine/threonine kinase activity / positive regulation of ceramide biosynthetic process / Apoptotic cleavage of cellular proteins / negative regulation of peptidyl-tyrosine phosphorylation / termination of signal transduction / Interferon gamma signaling / negative regulation of filopodium assembly / RHO GTPases Activate NADPH Oxidases / : / protein kinase C / cellular response to hydroperoxide / negative regulation of glial cell apoptotic process / collagen metabolic process / response to xenobiotic stimulus => GO:0009410 / D-aspartate import across plasma membrane / diacylglycerol-dependent serine/threonine kinase activity / negative regulation of actin filament polymerization / neutrophil activation / regulation of phosphorylation / positive regulation of endodeoxyribonuclease activity / negative regulation of platelet aggregation / cellular response to angiotensin / postsynaptic cytosol / Neutrophil degranulation / B cell proliferation / activation of protein kinase activity / immunoglobulin mediated immune response / enzyme activator activity / insulin receptor substrate binding / response to amino acid / cellular response to glucose starvation / response to glucose / response to mechanical stimulus / positive regulation of apoptotic signaling pathway / positive regulation of protein dephosphorylation / negative regulation of insulin receptor signaling pathway / response to organonitrogen compound / cell chemotaxis / negative regulation of MAP kinase activity / positive regulation of superoxide anion generation / regulation of actin cytoskeleton organization / positive regulation of glucose import / peptidyl-threonine phosphorylation / response to hydrogen peroxide / positive regulation of MAP kinase activity / response to organic cyclic compound / cellular response to hydrogen peroxide / nuclear matrix / kinase binding / positive regulation of protein import into nucleus / cellular response to insulin stimulus / cell-cell junction / cellular senescence / cellular response to oxidative stress / response to heat / peptidyl-serine phosphorylation / response to ethanol / response to oxidative stress / positive regulation of MAPK cascade / protein autophosphorylation / response to hypoxia / protein kinase activity / intracellular signal transduction / defense response to bacterium / cell cycle / positive regulation of apoptotic process / protein phosphorylation / protein serine/threonine kinase activity / apoptotic process / protein kinase binding / perinuclear region of cytoplasm / enzyme binding / endoplasmic reticulum / mitochondrion / ATP binding / membrane / metal ion binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function Protein kinase C, delta / Protein kinase C, delta/epsilon/eta/theta types / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / C2 domain / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain profile. / Zinc finger phorbol-ester/DAG-type profile. ... Protein kinase C, delta / Protein kinase C, delta/epsilon/eta/theta types / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / C2 domain / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain profile. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / C2 domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MIRAS / Resolution : 2.2 Å DetailsAuthors Pappa, H. / Murray-Rust, J. / Dekker, L.V. / Parker, P.J. / Mcdonald, N.Q. CitationJournal : Structure / Year : 1998Title : Crystal structure of the C2 domain from protein kinase C-delta.Authors : Pappa, H. / Murray-Rust, J. / Dekker, L.V. / Parker, P.J. / McDonald, N.Q. History Deposition May 11, 1998 Processing site : BNLRevision 1.0 Oct 14, 1998 Provider : repository / Type : Initial releaseRevision 1.1 Mar 24, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Feb 7, 2024 Group : Data collection / Database references / OtherCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site
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