+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 7klr | |||||||||
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タイトル | Solution structure of the PHD1 domain of histone demethylase KDM5A in complex with a histone H3(1-10) peptide | |||||||||
要素 |
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キーワード | GENE REGULATION (遺伝子発現の調節) / PHD / H3 / Epigenetics (エピジェネティクス) / KDM5A | |||||||||
機能・相同性 | 機能・相同性情報 [histone H3]-trimethyl-L-lysine4 demethylase / facultative heterochromatin formation / histone H3K4me/H3K4me2/H3K4me3 demethylase activity / enzyme inhibitor activity / regulation of DNA-binding transcription factor activity / histone demethylase activity / Chromatin modifying enzymes / epigenetic regulation of gene expression / methylated histone binding / telomere organization ...[histone H3]-trimethyl-L-lysine4 demethylase / facultative heterochromatin formation / histone H3K4me/H3K4me2/H3K4me3 demethylase activity / enzyme inhibitor activity / regulation of DNA-binding transcription factor activity / histone demethylase activity / Chromatin modifying enzymes / epigenetic regulation of gene expression / methylated histone binding / telomere organization / RNA Polymerase I Promoter Opening / Interleukin-7 signaling / Assembly of the ORC complex at the origin of replication / DNAメチル化 / Condensation of Prophase Chromosomes / HCMV Late Events / Chromatin modifications during the maternal to zygotic transition (MZT) / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / SIRT1 negatively regulates rRNA expression / PRC2 methylates histones and DNA / Defective pyroptosis / HDACs deacetylate histones / RNA Polymerase I Promoter Escape / Transcriptional regulation by small RNAs / Formation of the beta-catenin:TCF transactivating complex / circadian regulation of gene expression / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / NoRC negatively regulates rRNA expression / B-WICH complex positively regulates rRNA expression / HDMs demethylate histones / chromatin DNA binding / PKMTs methylate histone lysines / RMTs methylate histone arginines / 遺伝的組換え / Pre-NOTCH Transcription and Translation / nucleosome assembly / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / Transcriptional regulation of granulopoiesis / structural constituent of chromatin / ヌクレオソーム / 遺伝子発現 / RUNX1 regulates transcription of genes involved in differentiation of HSCs / chromatin organization / Factors involved in megakaryocyte development and platelet production / HATs acetylate histones / histone binding / Senescence-Associated Secretory Phenotype (SASP) / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / transcription coactivator activity / transcription cis-regulatory region binding / クロマチンリモデリング / cadherin binding / Amyloid fiber formation / protein heterodimerization activity / クロマチン / 核小体 / regulation of DNA-templated transcription / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / extracellular exosome / zinc ion binding / extracellular region / 核質 / 生体膜 / 細胞核 類似検索 - 分子機能 | |||||||||
生物種 | Homo sapiens (ヒト) | |||||||||
手法 | 溶液NMR / simulated annealing | |||||||||
データ登録者 | Longbotham, E.J. / Kelly, M.J.S. / Fujimori, D.G. | |||||||||
資金援助 | 米国, 2件
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引用 | ジャーナル: Acs Chem.Biol. / 年: 2021 タイトル: Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A. 著者: Longbotham, J.E. / Kelly, M.J.S. / Fujimori, D.G. | |||||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 7klr.cif.gz | 414.1 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb7klr.ent.gz | 355.6 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 7klr.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/kl/7klr ftp://data.pdbj.org/pub/pdb/validation_reports/kl/7klr | HTTPS FTP |
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-関連構造データ
関連構造データ | 7kloC C: 同じ文献を引用 (文献) |
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類似構造データ | |
その他のデータベース |
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-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質 | 分子量: 6605.556 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: KDM5A, JARID1A, RBBP2, RBP2 / 発現宿主: Escherichia coli BL21(DE3) (大腸菌) / 株 (発現宿主): BL21(DE3) 参照: UniProt: P29375, [histone H3]-trimethyl-L-lysine4 demethylase | ||
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#2: タンパク質・ペプチド | 分子量: 1150.332 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) 遺伝子: H3C1, H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, ...遺伝子: H3C1, H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J 発現宿主: synthetic construct (人工物) / 参照: UniProt: P68431 | ||
#3: 化合物 | 研究の焦点であるリガンドがあるか | N | |
-実験情報
-実験
実験 | 手法: 溶液NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR実験 |
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-試料調製
詳細 |
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