+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 6xk9 | ||||||
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タイトル | Cereblon in complex with DDB1, CC-90009, and GSPT1 | ||||||
要素 |
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キーワード | LIGASE (リガーゼ) / DDB1 / molecular glue / degradation / CC-90009 / Acute Myeloid Leukemia (急性骨髄性白血病) | ||||||
機能・相同性 | 機能・相同性情報 translation release factor complex / negative regulation of monoatomic ion transmembrane transport / regulation of translational termination / translation release factor activity / protein methylation / positive regulation by virus of viral protein levels in host cell / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair ...translation release factor complex / negative regulation of monoatomic ion transmembrane transport / regulation of translational termination / translation release factor activity / protein methylation / positive regulation by virus of viral protein levels in host cell / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / biological process involved in interaction with symbiont / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / regulation of mitotic cell cycle phase transition / WD40-repeat domain binding / Cul4A-RING E3 ubiquitin ligase complex / Cul4B-RING E3 ubiquitin ligase complex / ubiquitin ligase complex scaffold activity / negative regulation of reproductive process / negative regulation of developmental process / locomotory exploration behavior / cullin family protein binding / Eukaryotic Translation Termination / positive regulation of Wnt signaling pathway / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / viral release from host cell / ectopic germ cell programmed cell death / negative regulation of protein-containing complex assembly / positive regulation of viral genome replication / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / translational termination / positive regulation of gluconeogenesis / cytosolic ribosome / proteasomal protein catabolic process / nucleotide-excision repair / Recognition of DNA damage by PCNA-containing replication complex / positive regulation of protein-containing complex assembly / 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与 / G1/S transition of mitotic cell cycle / DNA Damage Recognition in GG-NER / regulation of circadian rhythm / Dual Incision in GG-NER / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / Formation of TC-NER Pre-Incision Complex / Wntシグナル経路 / Regulation of expression of SLITs and ROBOs / Formation of Incision Complex in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / positive regulation of protein catabolic process / cellular response to UV / rhythmic process / protein-macromolecule adaptor activity / site of double-strand break / Neddylation / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / Potential therapeutics for SARS / transmembrane transporter binding / chromosome, telomeric region / damaged DNA binding / protein ubiquitination / 翻訳 (生物学) / DNA修復 / GTPase activity / apoptotic process / DNA damage response / protein-containing complex binding / GTP binding / 核小体 / negative regulation of apoptotic process / perinuclear region of cytoplasm / protein-containing complex / DNA binding / extracellular space / RNA binding / extracellular exosome / 核質 / 生体膜 / metal ion binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.64 Å | ||||||
データ登録者 | Clayton, T.L. / Tran, E.T. / Zhu, J. / Pagarigan, B.E. / Matyskiela, M.E. / Chamberlain, P.P. | ||||||
引用 | ジャーナル: Blood / 年: 2021 タイトル: CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. 著者: Surka, C. / Jin, L. / Mbong, N. / Lu, C.C. / Jang, I.S. / Rychak, E. / Mendy, D. / Clayton, T. / Tindall, E. / Hsu, C. / Fontanillo, C. / Tran, E. / Contreras, A. / Ng, S.W.K. / Matyskiela, M. ...著者: Surka, C. / Jin, L. / Mbong, N. / Lu, C.C. / Jang, I.S. / Rychak, E. / Mendy, D. / Clayton, T. / Tindall, E. / Hsu, C. / Fontanillo, C. / Tran, E. / Contreras, A. / Ng, S.W.K. / Matyskiela, M. / Wang, K. / Chamberlain, P. / Cathers, B. / Carmichael, J. / Hansen, J. / Wang, J.C.Y. / Minden, M.D. / Fan, J. / Pierce, D.W. / Pourdehnad, M. / Rolfe, M. / Lopez-Girona, A. / Dick, J.E. / Lu, G. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 6xk9.cif.gz | 805.6 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb6xk9.ent.gz | 517.7 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 6xk9.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/xk/6xk9 ftp://data.pdbj.org/pub/pdb/validation_reports/xk/6xk9 | HTTPS FTP |
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-関連構造データ
関連構造データ | 5hxbS S: 精密化の開始モデル |
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類似構造データ |
-リンク
-集合体
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非結晶学的対称性 (NCS) | NCSドメイン:
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