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TitleCC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Journal, issue, pagesBlood, Vol. 137, Page 661-677, Year 2021
Publish dateJun 25, 2020 (structure data deposition date)
AuthorsSurka, C. / Jin, L. / Mbong, N. / Lu, C.C. / Jang, I.S. / Rychak, E. / Mendy, D. / Clayton, T. / Tindall, E. / Hsu, C. ...Surka, C. / Jin, L. / Mbong, N. / Lu, C.C. / Jang, I.S. / Rychak, E. / Mendy, D. / Clayton, T. / Tindall, E. / Hsu, C. / Fontanillo, C. / Tran, E. / Contreras, A. / Ng, S.W.K. / Matyskiela, M. / Wang, K. / Chamberlain, P. / Cathers, B. / Carmichael, J. / Hansen, J. / Wang, J.C.Y. / Minden, M.D. / Fan, J. / Pierce, D.W. / Pourdehnad, M. / Rolfe, M. / Lopez-Girona, A. / Dick, J.E. / Lu, G.
External linksBlood / PubMed:33197925
MethodsX-ray diffraction
Resolution3.64 Å
Structure data

PDB-6xk9:
Cereblon in complex with DDB1, CC-90009, and GSPT1
Method: X-RAY DIFFRACTION / Resolution: 3.64 Å

Chemicals

ChemComp-V4M:
2-(4-chlorophenyl)-N-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)-2,2-difluoroacetamide

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsLIGASE / DDB1 / molecular glue / degradation / CC-90009 / Acute Myeloid Leukemia

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