登録情報 | データベース: PDB / ID: 3mnp |
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タイトル | Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, V708A, E711G) mutations at 1.50A |
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要素 | - Glucocorticoid receptor糖質コルチコイド受容体
- Nuclear receptor coactivator 2 peptide
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キーワード | HORMONE RECEPTOR / protein-ligand complex / steroid nuclear receptor / mouse GR / agonist (アゴニスト) / co-activator (コアクチベーター) |
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機能・相同性 | 機能・相同性情報
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / SUMOylation of intracellular receptors / Recycling of bile acids and salts / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Nuclear Receptor transcription pathway / Synthesis of bile acids and bile salts / negative regulation of synaptic plasticity / positive regulation of glucocorticoid receptor signaling pathway / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand ...Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / SUMOylation of intracellular receptors / Recycling of bile acids and salts / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Nuclear Receptor transcription pathway / Synthesis of bile acids and bile salts / negative regulation of synaptic plasticity / positive regulation of glucocorticoid receptor signaling pathway / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / Endogenous sterols / HATs acetylate histones / intracellular glucocorticoid receptor signaling pathway / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / positive regulation of cell growth involved in cardiac muscle cell development / hormone binding / Regulation of lipid metabolism by PPARalpha / steroid hormone binding / Cytoprotection by HMOX1 / nuclear glucocorticoid receptor binding / neuroinflammatory response / glucocorticoid metabolic process / Estrogen-dependent gene expression / microglia differentiation / maternal behavior / mammary gland duct morphogenesis / nucleus localization / nuclear retinoic acid receptor binding / response to arsenic-containing substance / astrocyte differentiation / negative regulation of vascular permeability / positive regulation of glutamate secretion / cellular response to glucocorticoid stimulus / positive regulation of female receptivity / nuclear thyroid hormone receptor binding / motor behavior / regulation of gluconeogenesis / adrenal gland development / RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding / cellular response to steroid hormone stimulus / positive regulation of dendritic spine development / postsynaptic density, intracellular component / locomotor rhythm / aryl hydrocarbon receptor binding / regulation of lipid metabolic process / cellular response to Thyroglobulin triiodothyronine / regulation of glucose metabolic process / estrogen response element binding / DNA polymerase binding / nuclear retinoid X receptor binding / intracellular steroid hormone receptor signaling pathway / core promoter sequence-specific DNA binding / regulation of cellular response to insulin stimulus / cellular response to hormone stimulus / transcription initiation-coupled chromatin remodeling / Hsp70 protein binding / cellular response to transforming growth factor beta stimulus / heat shock protein binding / positive regulation of adipose tissue development / peroxisome proliferator activated receptor signaling pathway / TBP-class protein binding / steroid binding / cellular response to dexamethasone stimulus / nuclear receptor coactivator activity / response to progesterone / synaptic transmission, glutamatergic / nuclear estrogen receptor binding / nuclear receptor binding / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Hsp90 protein binding / circadian regulation of gene expression / mRNA transcription by RNA polymerase II / receptor tyrosine kinase binding / spindle / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of miRNA transcription / 概日リズム / RNA polymerase II transcription regulator complex / positive regulation of neuron apoptotic process / nuclear receptor activity / sequence-specific double-stranded DNA binding / 遺伝子発現 / regulation of cell population proliferation / double-stranded DNA binding / 遺伝子発現の調節 / DNA-binding transcription activator activity, RNA polymerase II-specific / transcription regulator complex / RNA polymerase II-specific DNA-binding transcription factor binding / sequence-specific DNA binding / 樹状突起スパイン / transcription coactivator activity / nuclear body / protein dimerization activity / nuclear speck / クロマチンリモデリング / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / protein domain specific binding / signaling receptor binding類似検索 - 分子機能 糖質コルチコイド受容体 / 糖質コルチコイド受容体 / 核内受容体コアクチベーター2 / Nuclear receptor coactivator 2/3, DUF4927 / Domain of unknown function (DUF4927) / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator ...糖質コルチコイド受容体 / 糖質コルチコイド受容体 / 核内受容体コアクチベーター2 / Nuclear receptor coactivator 2/3, DUF4927 / Domain of unknown function (DUF4927) / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator / DUF1518 / Nuclear receptor coactivator, receptor-binding domain / Nuclear receptor coactivator / Steroid receptor coactivator / Unstructured region on nuclear receptor coactivator protein / PAS domain / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Nuclear receptor coactivator, interlocking / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / Retinoid X Receptor / Retinoid X Receptor / 核内受容体 / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 デキサメタゾン / THIOCYANATE ION / 糖質コルチコイド受容体 / 核内受容体コアクチベーター2類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.5 Å |
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データ登録者 | Schoch, G.A. / Seitz, T. / Benz, J. / Banner, D. / Stihle, M. / D'Arcy, B. / Thoma, R. / Sterner, R. / Hennig, M. / Ruf, A. |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2010 タイトル: Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. 著者: Seitz, T. / Thoma, R. / Schoch, G.A. / Stihle, M. / Benz, J. / D'Arcy, B. / Wiget, A. / Ruf, A. / Hennig, M. / Sterner, R. |
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履歴 | 登録 | 2010年4月22日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2010年9月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2023年9月6日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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