登録情報 | データベース: PDB / ID: 3d7m |
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タイトル | Crystal Structure of the G Protein Fast-Exchange Double Mutant I56C/Q333C |
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要素 | Guanine nucleotide-binding protein G(i), alpha-1 subunit |
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キーワード | SIGNALING PROTEIN / nucleotide binding (ヌクレオチド) / allosteric (アロステリック効果) / GTP-binding / Lipoprotein (リポタンパク質) / Myristate (ミリスチン酸) / Nucleotide-binding / Palmitate (パルミチン酸) / Transducer (トランスデューサー) |
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機能・相同性 | 機能・相同性情報
Extra-nuclear estrogen signaling / Adenylate cyclase inhibitory pathway / Adrenaline,noradrenaline inhibits insulin secretion / ADP signalling through P2Y purinoceptor 12 / G alpha (i) signalling events / negative regulation of synaptic transmission / GTPase activating protein binding / positive regulation of protein localization to cell cortex / regulation of cAMP-mediated signaling / D2 dopamine receptor binding ...Extra-nuclear estrogen signaling / Adenylate cyclase inhibitory pathway / Adrenaline,noradrenaline inhibits insulin secretion / ADP signalling through P2Y purinoceptor 12 / G alpha (i) signalling events / negative regulation of synaptic transmission / GTPase activating protein binding / positive regulation of protein localization to cell cortex / regulation of cAMP-mediated signaling / D2 dopamine receptor binding / G protein-coupled serotonin receptor binding / regulation of mitotic spindle organization / cellular response to forskolin / G protein-coupled receptor binding / G-protein beta/gamma-subunit complex binding / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / GDP binding / heterotrimeric G-protein complex / 細胞皮質 / midbody / 細胞周期 / G protein-coupled receptor signaling pathway / 細胞分裂 / GTPase activity / 中心体 / GTP binding / magnesium ion binding / protein-containing complex / 細胞核 / 細胞膜 / 細胞質類似検索 - 分子機能 GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase ...GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / G-protein alpha subunit, group I / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 TETRAFLUOROALUMINATE ION / GUANOSINE-5'-DIPHOSPHATE / Guanine nucleotide-binding protein G(i) subunit alpha-1類似検索 - 構成要素 |
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生物種 | Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.9 Å |
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データ登録者 | Funk, M.A. / Preininger, A.M. / Oldham, W.M. / Meier, S.M. / Hamm, H.E. / Iverson, T.M. |
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引用 | ジャーナル: Biochemistry / 年: 2009 タイトル: Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. 著者: Preininger, A.M. / Funk, M.A. / Oldham, W.M. / Meier, S.M. / Johnston, C.A. / Adhikary, S. / Kimple, A.J. / Siderovski, D.P. / Hamm, H.E. / Iverson, T.M. |
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履歴 | 登録 | 2008年5月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2009年3月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2017年10月25日 | Group: Refinement description / カテゴリ: software |
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改定 1.3 | 2021年10月20日 | Group: Database references / Derived calculations カテゴリ: database_2 / struct_conn ...database_2 / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.4 | 2023年8月30日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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