登録情報 | データベース: PDB / ID: 2knf |
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タイトル | Solution structure and functional characterization of human plasminogen kringle 5 |
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要素 | Plasminogenプラスミン |
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キーワード | BLOOD CLOTTING (凝固・線溶系) / Blood coagulation (凝固・線溶系) / Cleavage on pair of basic residues / Disease mutation / Disulfide bond (ジスルフィド) / Fibrinolysis / Glycoprotein (糖タンパク質) / Hydrolase (加水分解酵素) / Kringle / Phosphoprotein / Polymorphism / Protease (プロテアーゼ) / Secreted (分泌) / Serine protease (セリンプロテアーゼ) / Thrombophilia / Tissue remodeling / Zymogen (酵素前駆体) / antiangiogenic |
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機能・相同性 | 機能・相同性情報
プラスミン / trans-synaptic signaling by BDNF, modulating synaptic transmission / trophoblast giant cell differentiation / tissue remodeling / protein antigen binding / 再生 (生物学) / mononuclear cell migration / Signaling by PDGF / negative regulation of cell-cell adhesion mediated by cadherin / positive regulation of fibrinolysis ...プラスミン / trans-synaptic signaling by BDNF, modulating synaptic transmission / trophoblast giant cell differentiation / tissue remodeling / protein antigen binding / 再生 (生物学) / mononuclear cell migration / Signaling by PDGF / negative regulation of cell-cell adhesion mediated by cadherin / positive regulation of fibrinolysis / Dissolution of Fibrin Clot / negative regulation of cell-substrate adhesion / myoblast differentiation / biological process involved in interaction with symbiont / labyrinthine layer blood vessel development / muscle cell cellular homeostasis / Activation of Matrix Metalloproteinases / apolipoprotein binding / extracellular matrix disassembly / positive regulation of blood vessel endothelial cell migration / negative regulation of fibrinolysis / fibrinolysis / Degradation of the extracellular matrix / serine-type peptidase activity / platelet alpha granule lumen / Schaffer collateral - CA1 synapse / kinase binding / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / 凝固・線溶系 / Platelet degranulation / protein-folding chaperone binding / collagen-containing extracellular matrix / blood microparticle / endopeptidase activity / protease binding / protein domain specific binding / negative regulation of cell population proliferation / external side of plasma membrane / signaling receptor binding / serine-type endopeptidase activity / glutamatergic synapse / enzyme binding / 細胞膜 / タンパク質分解 / extracellular space / extracellular exosome / extracellular region / 細胞膜類似検索 - 分子機能 Peptidase S1A, plasmin / Plasminogen Kringle 4 / Plasminogen Kringle 4 / divergent subfamily of APPLE domains / PAN/Apple domain profile. / PAN domain / PAN/Apple domain / Kringle domain / Kringle / Kringle, conserved site ...Peptidase S1A, plasmin / Plasminogen Kringle 4 / Plasminogen Kringle 4 / divergent subfamily of APPLE domains / PAN/Apple domain profile. / PAN domain / PAN/Apple domain / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / トリプシン / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Βバレル / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing, molecular dynamics |
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データ登録者 | Battistel, M.D. / Grishaev, A. / An, S.A. / Castellino, F.J. / Llinas, M. |
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引用 | ジャーナル: Biochemistry / 年: 2009 タイトル: Solution structure and functional characterization of human plasminogen kringle 5. 著者: Battistel, M.D. / Grishaev, A. / An, S.S. / Castellino, F.J. / Llinas, M. |
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履歴 | 登録 | 2009年8月21日 | 登録サイト: BMRB / 処理サイト: RCSB |
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改定 1.0 | 2009年10月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2020年2月26日 | Group: Database references / Derived calculations / Other カテゴリ: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item: _pdbx_database_status.status_code_cs / _struct_ref_seq_dif.details |
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改定 1.3 | 2021年10月13日 | Group: Database references / カテゴリ: database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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