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データを開く
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基本情報
登録情報 | データベース: SASBDB / ID: SASDA89 |
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![]() | Complex between ovine GM-CSF and GM-CSF/IL-2 inhibition factor
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機能・相同性 | ![]() granulocyte macrophage colony-stimulating factor receptor binding / neutrophil differentiation / positive regulation of interleukin-23 production / positive regulation of macrophage derived foam cell differentiation / myeloid dendritic cell differentiation / granulocyte macrophage colony-stimulating factor receptor complex / granulocyte-macrophage colony-stimulating factor signaling pathway / positive regulation of leukocyte proliferation / cellular response to granulocyte macrophage colony-stimulating factor stimulus / positive regulation of podosome assembly ...granulocyte macrophage colony-stimulating factor receptor binding / neutrophil differentiation / positive regulation of interleukin-23 production / positive regulation of macrophage derived foam cell differentiation / myeloid dendritic cell differentiation / granulocyte macrophage colony-stimulating factor receptor complex / granulocyte-macrophage colony-stimulating factor signaling pathway / positive regulation of leukocyte proliferation / cellular response to granulocyte macrophage colony-stimulating factor stimulus / positive regulation of podosome assembly / cell surface receptor signaling pathway via JAK-STAT / monocyte differentiation / macrophage differentiation / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / embryonic placenta development / positive regulation of tyrosine phosphorylation of STAT protein / cytokine activity / growth factor activity / cell population proliferation / immune response / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / extracellular space 類似検索 - 分子機能 |
生物種 | ![]() ![]() ![]() |
![]() | ![]() タイトル: Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF 著者: Felix J / Kandiah E / De Munck S / Bloch Y / van Zundert G / Pauwels K / Dansercoer A / Novanska K / Read R / Bonvin A / Vergauwen B / Verstraete K / Gutsche I |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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ダウンロードとリンク
-モデル
モデル #353 | ![]() タイプ: mix / ソフトウェア: FoXS / ダミー原子の半径: 1.90 A / カイ2乗値: 183.782981843 ![]() |
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試料
![]() | 名称: Complex between ovine GM-CSF and GM-CSF/IL-2 inhibition factor Purity method: SEC-SAXS / 試料濃度: 9.7 mg/ml / Entity id: 209 / 210 |
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バッファ | 名称: HEPES / 濃度: 20.00 mM / pH: 7.4 / 組成: 150 mM NaCl |
要素 #209 | タイプ: protein / 記述: GM-CSF/IL-2 inhibition factor / 分子量: 29.924 / 分子数: 4 / 由来: Orf virus / 参照: UniProt: Q9J5U5 配列: MACLRVFLAV LALCGSVHSA QWIGERDFCT AHAQDVFARL QVWMRIDRNV TAADNSSACA LAIETPPSNF DADVYVAAAG INVSVSAINC GFFNMRQVET TYNTARRQMY VYMDSWDPWV IDDPQPLFSQ EYENETLPYL LEVLELARLY IRVGCTVPGE QPFEVIPGID ...配列: MACLRVFLAV LALCGSVHSA QWIGERDFCT AHAQDVFARL QVWMRIDRNV TAADNSSACA LAIETPPSNF DADVYVAAAG INVSVSAINC GFFNMRQVET TYNTARRQMY VYMDSWDPWV IDDPQPLFSQ EYENETLPYL LEVLELARLY IRVGCTVPGE QPFEVIPGID YPHTGMEFLQ HVLRPNRRFA PAKLHMDLEV DHRCVSAVHV KAFLQDACSA RKARTPLYFA GHGCNHPDRR PKNPVPRPQH VSSPISRKCS MQTAR |
要素 #210 | タイプ: protein / 記述: Granulocyte-macrophage colony-stimulating factor / 分子量: 14.411 / 分子数: 2 / 由来: Ovis aries / 参照: UniProt: P28773 配列: APTRQPSPVT RPWQHVDAIK EALSLLNDST DTAAVMDETV EVVSEMFDSQ EPTCLQTRLE LYKQGLRGSL TSLTGSLTMM ASHYKKHCPP TQETSCETQI ITFKSFKENL KDFLFIIPFD CWEPVQK |
-実験情報
ビーム | 設備名称: SOLEIL SWING ![]() ![]() | |||||||||||||||||||||||||||||||||
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検出器 | 名称: AVIEX / タイプ: CCD | |||||||||||||||||||||||||||||||||
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距離分布関数 P(R) |
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結果 | コメント: Modeling of SAXS data: The crystal structure of the GIF:oGM-CSF complex was used as an input for the Allosmod-FoXS web server to model missing loops, N- and C-termini and N-linked ...コメント: Modeling of SAXS data: The crystal structure of the GIF:oGM-CSF complex was used as an input for the Allosmod-FoXS web server to model missing loops, N- and C-termini and N-linked glycosylation. During each Allosmod-FoXS run, data up to a scattering angle of 0.5 Å-1 was used. Fits to the experimental SAXS data were calculated using the FoXS software.
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