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Open data
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Basic information
Entry | Database: SASBDB / ID: SASDA99 |
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![]() | Complex between ovine IL-2 and GM-CSF/IL-2 inhibition factor
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Function / homology | ![]() interleukin-2 receptor binding / positive regulation of plasma cell differentiation / leukocyte activation involved in immune response / negative regulation of B cell apoptotic process / positive regulation of immunoglobulin production / positive regulation of activated T cell proliferation / positive regulation of interleukin-17 production / positive regulation of B cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / cytokine activity ...interleukin-2 receptor binding / positive regulation of plasma cell differentiation / leukocyte activation involved in immune response / negative regulation of B cell apoptotic process / positive regulation of immunoglobulin production / positive regulation of activated T cell proliferation / positive regulation of interleukin-17 production / positive regulation of B cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / cytokine activity / growth factor activity / adaptive immune response / extracellular space Similarity search - Function |
Biological species | ![]() ![]() ![]() |
![]() | ![]() Title: Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF Authors: Felix J / Kandiah E / De Munck S / Bloch Y / van Zundert G / Pauwels K / Dansercoer A / Novanska K / Read R / Bonvin A / Vergauwen B / Verstraete K / Gutsche I |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
-Data source
SASBDB page | ![]() |
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-Related structure data
Related structure data | C: citing same article ( |
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Similar structure data |
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External links
Related items in Molecule of the Month |
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-Models
Model #550 | ![]() Type: mix / Software: FoxS / Radius of dummy atoms: 1.90 A / Chi-square value: 35.9502544171 ![]() |
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Sample
![]() | Name: Complex between ovine IL-2 and GM-CSF/IL-2 inhibition factor Purity method: SEC-SAXS / Specimen concentration: 8.8 mg/ml / Entity id: 209 / 212 |
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Buffer | Name: HEPES / Concentration: 20.00 mM / pH: 7.4 / Composition: 150 mM NaCl |
Entity #209 | Type: protein / Description: GM-CSF/IL-2 inhibition factor / Formula weight: 29.924 / Num. of mol.: 4 / Source: Orf virus / References: UniProt: Q9J5U5 Sequence: MACLRVFLAV LALCGSVHSA QWIGERDFCT AHAQDVFARL QVWMRIDRNV TAADNSSACA LAIETPPSNF DADVYVAAAG INVSVSAINC GFFNMRQVET TYNTARRQMY VYMDSWDPWV IDDPQPLFSQ EYENETLPYL LEVLELARLY IRVGCTVPGE QPFEVIPGID ...Sequence: MACLRVFLAV LALCGSVHSA QWIGERDFCT AHAQDVFARL QVWMRIDRNV TAADNSSACA LAIETPPSNF DADVYVAAAG INVSVSAINC GFFNMRQVET TYNTARRQMY VYMDSWDPWV IDDPQPLFSQ EYENETLPYL LEVLELARLY IRVGCTVPGE QPFEVIPGID YPHTGMEFLQ HVLRPNRRFA PAKLHMDLEV DHRCVSAVHV KAFLQDACSA RKARTPLYFA GHGCNHPDRR PKNPVPRPQH VSSPISRKCS MQTAR |
Entity #212 | Type: protein / Description: Interleukin-2 / Formula weight: 15.56 / Num. of mol.: 1 / Source: Ovis aries / References: UniProt: P19114 Sequence: APTSSSTGNT MKEVKSLLLD LQLLLEKVKN PENLKLSRMH TFNFYMPKVN ATELKHLKCL LEELKLLEEV LDLAPSKNLN TREIKDSMDN IKRIVLELQG SETRFTCEYD DATVKAVEFL NKWITFCQSI YSTMT |
-Experimental information
Beam | Instrument name: SOLEIL SWING ![]() ![]() | ||||||||||||||||||||||||||||||||||||
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Detector | Name: AVIEX / Type: CCD | ||||||||||||||||||||||||||||||||||||
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Distance distribution function P(R) |
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Result | Comments: Modeling of SAXS data: A model of the GIF:IL-2 complex, based on the fit in a low-resolution (24 Å) map obtained by Negative-Stain Electron Microscopy, was used as an input for the ...Comments: Modeling of SAXS data: A model of the GIF:IL-2 complex, based on the fit in a low-resolution (24 Å) map obtained by Negative-Stain Electron Microscopy, was used as an input for the Allosmod-FoXS web server to model missing loops, N- and C-termini and N-linked glycosylation. During each Allosmod-FoXS run, data up to a scattering angle of 0.5 Å-1 was used. Fits to the experimental SAXS data were calculated using the FoXS software. Note that the exact orientation of IL-2 is uncertain due to the low resolution of the EM map.
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