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- SASDF83: Bruton's Tyrosine Kinase - Full-length (Bruton's tyrosine kinase ... -

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ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDF83
SampleBruton's Tyrosine Kinase - Full-length
  • Bruton's tyrosine kinase - full length (protein), hBTK - FL, Homo sapiens
Function / homology
Function and homology information


regulation of B cell cytokine production / proteoglycan catabolic process / monocyte proliferation / positive regulation of interleukin-17A production / regulation of B cell apoptotic process / eosinophil homeostasis / positive regulation of type III hypersensitivity / B cell affinity maturation / histamine secretion by mast cell / positive regulation of synoviocyte proliferation ...regulation of B cell cytokine production / proteoglycan catabolic process / monocyte proliferation / positive regulation of interleukin-17A production / regulation of B cell apoptotic process / eosinophil homeostasis / positive regulation of type III hypersensitivity / B cell affinity maturation / histamine secretion by mast cell / positive regulation of synoviocyte proliferation / neutrophil homeostasis / cellular response to molecule of fungal origin / positive regulation of type I hypersensitivity / cellular response to interleukin-7 / MyD88 deficiency (TLR2/4) / MyD88-dependent toll-like receptor signaling pathway / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / positive regulation of B cell differentiation / positive regulation of NLRP3 inflammasome complex assembly / phospholipase activator activity / negative regulation of interleukin-10 production / B cell activation / negative regulation of B cell proliferation / Fc-epsilon receptor signaling pathway / phospholipase binding / mesoderm development / phosphatidylinositol-3,4,5-trisphosphate binding / positive regulation of immunoglobulin production / RHO GTPases Activate WASPs and WAVEs / positive regulation of phagocytosis / positive regulation of B cell proliferation / cell maturation / FCERI mediated Ca+2 mobilization / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / calcium-mediated signaling / apoptotic signaling pathway / FCGR3A-mediated phagocytosis / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / G beta:gamma signalling through BTK / Regulation of actin dynamics for phagocytic cup formation / cellular response to reactive oxygen species / positive regulation of interleukin-6 production / peptidyl-tyrosine phosphorylation / G alpha (12/13) signalling events / positive regulation of tumor necrosis factor production / DAP12 signaling / positive regulation of NF-kappaB transcription factor activity / ER-Phagosome pathway / T cell receptor signaling pathway / cytoplasmic vesicle / G alpha (q) signalling events / protein tyrosine kinase activity / Potential therapeutics for SARS / response to lipopolysaccharide / adaptive immune response / intracellular signal transduction / membrane raft / protein phosphorylation / innate immune response / perinuclear region of cytoplasm / ATP binding / identical protein binding / metal ion binding / nucleus / plasma membrane / cytosol / cytoplasm
Similarity search - Function
Tyrosine-protein kinase BTK, SH3 domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain ...Tyrosine-protein kinase BTK, SH3 domain / Zinc finger, Btk motif / BTK motif / Zinc finger Btk-type profile. / Bruton's tyrosine kinase Cys-rich motif / PH domain / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / PH-like domain superfamily / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily
Similarity search - Domain/homology
Tyrosine-protein kinase BTK
Similarity search - Component
Biological speciesHomo sapiens (human)
Contact author
  • Daniel Duarte (EPFL)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #2819
Type: dummy / Radius of dummy atoms: 4.00 A / Chi-square value: 1.414 / P-value: 0.000303
Search similar-shape structures of this assembly by Omokage search (details)
Model #2820
Type: mix / Comment: Best fitting model derived from SASDC52 / Chi-square value: 6.174
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Bruton's Tyrosine Kinase - Full-length / Specimen concentration: 0.42-5.18
BufferName: 20mM Tris, 150mM NaCl, 1mM TCEP, 5% glycerol / pH: 7.5
Entity #1455Name: hBTK - FL / Type: protein / Description: Bruton's tyrosine kinase - full length / Formula weight: 76.684 / Num. of mol.: 1 / Source: Homo sapiens / References: UniProt: Q06187
Sequence: GAMGSMAAVI LESIFLKRSQ QKKKTSPLNF KKRLFLLTVH KLSYYEYDFE RGRRGSKKGS IDVEKITCVE TVVPEKNPPP ERQIPRRGEE SSEMEQISII ERFPYPFQVV YDEGPLYVFS PTEELRKRWI HQLKNVIRYN SDLVQKYHPC FWIDGQYLCC SQTAKNAMGC ...Sequence:
GAMGSMAAVI LESIFLKRSQ QKKKTSPLNF KKRLFLLTVH KLSYYEYDFE RGRRGSKKGS IDVEKITCVE TVVPEKNPPP ERQIPRRGEE SSEMEQISII ERFPYPFQVV YDEGPLYVFS PTEELRKRWI HQLKNVIRYN SDLVQKYHPC FWIDGQYLCC SQTAKNAMGC QILENRNGSL KPGSSHRKTK KPLPPTPEED QILKKPLPPE PAAAPVSTSE LKKVVALYDY MPMNANDLQL RKGDEYFILE ESNLPWWRAR DKNGQEGYIP SNYVTEAEDS IEMYEWYSKH MTRSQAEQLL KQEGKEGGFI VRDSSKAGKY TVSVFAKSTG DPQGVIRHYV VCSTPQSQYY LAEKHLFSTI PELINYHQHN SAGLISRLKY PVSQQNKNAP STAGLGYGSW EIDPKDLTFL KELGTGQFGV VKYGKWRGQY DVAIKMIKEG SMSEDEFIEE AKVMMNLSHE KLVQLYGVCT KQRPIFIITE YMANGCLLNY LREMRHRFQT QQLLEMCKDV CEAMEYLESK QFLHRDLAAR NCLVNDQGVV KVSDFGLSRY VLDDEYTSSV GSKFPVRWSP PEVLMYSKFS SKSDIWAFGV LMWEIYSLGK MPYERFTNSE TAEHIAQGLR LYRPHLASEK VYTIMYSCWH EKADERPTFK ILLSNILDVM DEES

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Experimental information

BeamInstrument name: ESRF BM29 / City: Grenoble / 国: France / Type of source: X-ray synchrotronSynchrotron / Wavelength: 0.09919 Å / Dist. spec. to detc.: 2.869 mm
DetectorName: Pilatus 1M / Type: Dectris / Pixsize x: 172 mm
Scan
Title: Bruton's Tyrosine Kinase - Full-length / Measurement date: Nov 3, 2018 / Storage temperature: 10 °C / Cell temperature: 10 °C / Exposure time: 1 sec. / Number of frames: 10 / Unit: 1/nm /
MinMax
Q0.0816 4.9462
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 654 /
MinMax
Q0.0816413 1.97709
P(R) point1 654
R0 15.6
Result
Type of curve: merged /
ExperimentalPorod
MW67.075 kDa71 kDa
Volume-114.07 nm3

P(R)GuinierGuinier error
Forward scattering, I061.31 60.23 0.17
Radius of gyration, Rg4.339 nm4.04 nm0.02

MinMax
D-15.6
Guinier point1 64

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