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Yorodumi- SASDDK7: Disrupted-in-Schizophrenia 1 protein (DISC1 12d2) (Disrupted- in-... -
+Open data
-Basic information
Entry | Database: SASBDB / ID: SASDDK7 |
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Sample | Disrupted-in-Schizophrenia 1 protein (DISC1 12d2)
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Function / homology | Function and homology information pyramidal neuron migration to cerebral cortex / mitochondrial calcium ion homeostasis / cell proliferation in forebrain / central region of growth cone / regulation of dendritic spine development / dynein complex / regulation of synapse maturation / positive regulation of ubiquitin-dependent protein catabolic process / non-motile cilium assembly / protein localization to centrosome ...pyramidal neuron migration to cerebral cortex / mitochondrial calcium ion homeostasis / cell proliferation in forebrain / central region of growth cone / regulation of dendritic spine development / dynein complex / regulation of synapse maturation / positive regulation of ubiquitin-dependent protein catabolic process / non-motile cilium assembly / protein localization to centrosome / intermediate filament cytoskeleton / positive regulation of cell-matrix adhesion / regulation of postsynapse organization / ciliary base / kinesin complex / positive regulation of neuroblast proliferation / detection of temperature stimulus involved in sensory perception of pain / kinesin binding / cilium assembly / positive regulation of Wnt signaling pathway / TOR signaling / canonical Wnt signaling pathway / positive regulation of axon extension / response to electrical stimulus / GABA-ergic synapse / regulation of synaptic transmission, glutamatergic / ciliary basal body / negative regulation of protein binding / neuron migration / positive regulation of neuron projection development / microtubule cytoskeleton organization / neuron cellular homeostasis / synaptic vesicle / presynapse / cell body / ubiquitin-dependent protein catabolic process / microtubule / molecular adaptor activity / postsynaptic density / centrosome / glutamatergic synapse / protein-containing complex binding / perinuclear region of cytoplasm / mitochondrion / identical protein binding / cytosol Similarity search - Function |
Citation | Date: 2018 Jan 11 Title: Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein Authors: Yerabham A / Müller-Schiffmann A / Ziehm T / Stadler A / Köber S / Indurkhya X / Marreiros R / Trossbach S / Bradshaw N / Prikulis I / Willbold D / Weiergräber O |
Contact author |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Models
Model #2011 | Type: dummy / Radius of dummy atoms: 1.90 A / Chi-square value: 5.76 Search similar-shape structures of this assembly by Omokage search (details) |
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Model #2012 | Type: dummy / Software: (2.8.3) / Radius of dummy atoms: 2.50 A / Chi-square value: 5.76 Search similar-shape structures of this assembly by Omokage search (details) |
Model #2013 | Type: dummy / Software: (2.8.3) / Radius of dummy atoms: 2.00 A / Chi-square value: 1.170724 / P-value: 0.000321 Search similar-shape structures of this assembly by Omokage search (details) |
Model #2014 | Type: dummy / Software: (2.8.3) / Radius of dummy atoms: 2.50 A / Chi-square value: 1.170724 / P-value: 0.000321 Search similar-shape structures of this assembly by Omokage search (details) |
-Sample
Sample | Name: Disrupted-in-Schizophrenia 1 protein (DISC1 12d2) / Specimen concentration: 2.8 mg/ml |
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Buffer | Name: 25 mM Tris-HCl, 150 mM NaCl, 1mM DTT / pH: 7.4 |
Entity #1077 | Name: DISC1 12D2 / Type: protein Description: Disrupted- in-schizophrenia 1 (DISC1 12D2) 691-836 Formula weight: 19.426 / Num. of mol.: 1 / References: UniProt: Q9NRI5 Sequence: MGHHHHHHDY DIPTTENLYF QGWEADLEAC RLLIQSLQLQ EARGSLSVED ERQMDDLEGA APPIPPRLHS EDKRKTPLKV LEEWKTHLIP SLHCAGGEQK EESYILSAEL GEKCEDIGKK LLYLEDQLHT AIHSHDEDLI QSLRRELQMV KETLQAMILQ LQPAKEAGSG |
-Experimental information
Beam | Instrument name: PETRA III EMBL P12 / City: Hamburg / 国: Germany / Shape: Point / Type of source: X-ray synchrotron / Wavelength: 0.123987 Å / Dist. spec. to detc.: 3 mm | |||||||||||||||||||||||||||||||||
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Detector | Name: Pilatus 1M-W / Pixsize x: 0.172 mm | |||||||||||||||||||||||||||||||||
Scan | Title: Disrupted-in-Schizophrenia 1 protein (DISC1 12d2) / Measurement date: Oct 1, 2015 / Storage temperature: 20 °C / Cell temperature: 20 °C / Exposure time: 0.095 sec. / Number of frames: 20 / Unit: 1/nm /
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Distance distribution function P(R) | Sofotware P(R): GNOM 5.0 / Number of points: 1115 /
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Result | Type of curve: single_conc
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