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Yorodumi- SASDDM7: Complex of disrupted-in-Schizophrenia 1 protein (DISC1 12D2) and ... -
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-Basic information
Entry | Database: SASBDB / ID: SASDDM7 |
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Sample | Complex of disrupted-in-Schizophrenia 1 protein (DISC1 12D2) and anti-DISC1 single-domain camelid antibody VHH B5
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Function / homology | Function and homology information pyramidal neuron migration to cerebral cortex / mitochondrial calcium ion homeostasis / central region of growth cone / cell proliferation in forebrain / regulation of dendritic spine development / regulation of synapse maturation / dynein complex / positive regulation of ubiquitin-dependent protein catabolic process / non-motile cilium assembly / protein localization to centrosome ...pyramidal neuron migration to cerebral cortex / mitochondrial calcium ion homeostasis / central region of growth cone / cell proliferation in forebrain / regulation of dendritic spine development / regulation of synapse maturation / dynein complex / positive regulation of ubiquitin-dependent protein catabolic process / non-motile cilium assembly / protein localization to centrosome / regulation of postsynapse organization / intermediate filament cytoskeleton / positive regulation of cell-matrix adhesion / kinesin complex / ciliary base / positive regulation of neuroblast proliferation / TOR signaling / detection of temperature stimulus involved in sensory perception of pain / kinesin binding / cilium assembly / positive regulation of Wnt signaling pathway / canonical Wnt signaling pathway / GABA-ergic synapse / positive regulation of axon extension / response to electrical stimulus / regulation of synaptic transmission, glutamatergic / ciliary basal body / negative regulation of protein binding / neuron migration / microtubule cytoskeleton organization / positive regulation of neuron projection development / neuron cellular homeostasis / synaptic vesicle / presynapse / cell body / ubiquitin-dependent protein catabolic process / microtubule / postsynaptic density / molecular adaptor activity / centrosome / glutamatergic synapse / protein-containing complex binding / perinuclear region of cytoplasm / mitochondrion / identical protein binding / cytosol Similarity search - Function |
Citation | Date: 2018 Jan 11 Title: Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein Authors: Yerabham A / Müller-Schiffmann A / Ziehm T / Stadler A / Köber S / Indurkhya X / Marreiros R / Trossbach S / Bradshaw N / Prikulis I / Willbold D / Weiergräber O |
Contact author |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Models
Model #2019 | Type: dummy / Software: (2.8.3) / Radius of dummy atoms: 2.20 A / Chi-square value: 0.652 / P-value: 0.000475 Search similar-shape structures of this assembly by Omokage search (details) |
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Model #2020 | Type: dummy / Software: (2.8.3) / Radius of dummy atoms: 2.75 A / Chi-square value: 0.652 / P-value: 0.000475 Search similar-shape structures of this assembly by Omokage search (details) |
-Sample
Sample | Name: Complex of disrupted-in-Schizophrenia 1 protein (DISC1 12D2) and anti-DISC1 single-domain camelid antibody VHH B5 Specimen concentration: 2.35 mg/ml / Entity id: 1073 / 1077 |
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Buffer | Name: 25 mM Tris-HCl, 150 mM NaCl, 1mM DTT / pH: 7.4 |
Entity #1073 | Name: VHH B5 / Type: protein Description: anti-DISC1 single-domain camelid antibody VHH B5 Formula weight: 13.924 / Num. of mol.: 1 Sequence: MAQVKLEESG GGLVQAGGSL RLSCAASGTL FSISVMGWYR QAPGMQRELV GSITDGGSTI YGDSVKGRFA ISKDNAKRTI YLQMNSLKPE DTAVYYCNYR RLTSNYWGQG TQVTVSSAAA LEHHHHHH |
Entity #1077 | Name: DISC1 12D2 / Type: protein Description: Disrupted- in-schizophrenia 1 (DISC1 12D2) 691-836 Formula weight: 19.426 / Num. of mol.: 1 / References: UniProt: Q9NRI5 Sequence: MGHHHHHHDY DIPTTENLYF QGWEADLEAC RLLIQSLQLQ EARGSLSVED ERQMDDLEGA APPIPPRLHS EDKRKTPLKV LEEWKTHLIP SLHCAGGEQK EESYILSAEL GEKCEDIGKK LLYLEDQLHT AIHSHDEDLI QSLRRELQMV KETLQAMILQ LQPAKEAGSG |
-Experimental information
Beam | Instrument name: ESRF BM29 / City: Grenoble / 国: France / Type of source: X-ray synchrotronSynchrotron / Wavelength: 0.1 Å | |||||||||||||||||||||||||||||||||
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Detector | Name: Pilatus 1M | |||||||||||||||||||||||||||||||||
Scan | Title: Complex of disrupted-in-Schizophrenia 1 protein (DISC1 12D2) and anti-DISC1 single-domain camelid antibody VHH B5 Measurement date: Feb 19, 2016 / Storage temperature: 20 °C / Cell temperature: 20 °C / Exposure time: 1 sec. / Number of frames: 10 / Unit: 1/nm /
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Distance distribution function P(R) | Sofotware P(R): GNOM 5.0 / Number of points: 516 /
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Result | Type of curve: single_conc
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