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- SASDDK7: Disrupted-in-Schizophrenia 1 protein (DISC1 12d2) (Disrupted- in-... -

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ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDDK7
SampleDisrupted-in-Schizophrenia 1 protein (DISC1 12d2)
  • Disrupted- in-schizophrenia 1 (DISC1 12D2) 691-836 (protein), DISC1 12D2
Function / homology
Function and homology information


pyramidal neuron migration to cerebral cortex / cell proliferation in forebrain / central region of growth cone / mitochondrial calcium ion homeostasis / regulation of dendritic spine development / regulation of synapse maturation / intermediate filament cytoskeleton / non-motile cilium assembly / positive regulation of ubiquitin-dependent protein catabolic process / dynein complex ...pyramidal neuron migration to cerebral cortex / cell proliferation in forebrain / central region of growth cone / mitochondrial calcium ion homeostasis / regulation of dendritic spine development / regulation of synapse maturation / intermediate filament cytoskeleton / non-motile cilium assembly / positive regulation of ubiquitin-dependent protein catabolic process / dynein complex / protein localization to centrosome / regulation of postsynapse organization / kinesin complex / positive regulation of cell-matrix adhesion / positive regulation of neuroblast proliferation / ciliary base / detection of temperature stimulus involved in sensory perception of pain / TOR signaling / microtubule organizing center / response to electrical stimulus / cilium assembly / kinesin binding / positive regulation of Wnt signaling pathway / canonical Wnt signaling pathway / positive regulation of axon extension / regulation of synaptic transmission, glutamatergic / positive regulation of neuron projection development / neuron cellular homeostasis / GABA-ergic synapse / microtubule cytoskeleton organization / neuron migration / synaptic vesicle / presynapse / cell body / ubiquitin-dependent protein catabolic process / molecular adaptor activity / microtubule / postsynaptic density / ciliary basal body / centrosome / protein-containing complex binding / perinuclear region of cytoplasm / glutamatergic synapse / mitochondrion / identical protein binding / cytosol
Similarity search - Function
Disrupted in schizophrenia 1
Similarity search - Domain/homology
Disrupted in schizophrenia 1 protein
Similarity search - Component
CitationDate: 2018 Jan 11
Title: Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein
Authors: Yerabham A / Müller-Schiffmann A / Ziehm T / Stadler A / Köber S / Indurkhya X / Marreiros R / Trossbach S / Bradshaw N / Prikulis I / Willbold D / Weiergräber O
Contact author
  • Andreas Stadler (Forschungszentrum Jülich)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Models

Model #2011
Type: dummy / Radius of dummy atoms: 1.90 A / Chi-square value: 5.76
Search similar-shape structures of this assembly by Omokage search (details)
Model #2012
Type: dummy / Software: (2.8.3) / Radius of dummy atoms: 2.50 A / Chi-square value: 5.76
Search similar-shape structures of this assembly by Omokage search (details)
Model #2013
Type: dummy / Software: (2.8.3) / Radius of dummy atoms: 2.00 A / Chi-square value: 1.170724 / P-value: 0.000321
Search similar-shape structures of this assembly by Omokage search (details)
Model #2014
Type: dummy / Software: (2.8.3) / Radius of dummy atoms: 2.50 A / Chi-square value: 1.170724 / P-value: 0.000321
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Disrupted-in-Schizophrenia 1 protein (DISC1 12d2) / Specimen concentration: 2.8 mg/ml
BufferName: 25 mM Tris-HCl, 150 mM NaCl, 1mM DTT / pH: 7.4
Entity #1077Name: DISC1 12D2 / Type: protein
Description: Disrupted- in-schizophrenia 1 (DISC1 12D2) 691-836
Formula weight: 19.426 / Num. of mol.: 1 / References: UniProt: Q9NRI5
Sequence:
MGHHHHHHDY DIPTTENLYF QGWEADLEAC RLLIQSLQLQ EARGSLSVED ERQMDDLEGA APPIPPRLHS EDKRKTPLKV LEEWKTHLIP SLHCAGGEQK EESYILSAEL GEKCEDIGKK LLYLEDQLHT AIHSHDEDLI QSLRRELQMV KETLQAMILQ LQPAKEAGSG

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Experimental information

BeamInstrument name: PETRA III EMBL P12 / City: Hamburg / 国: Germany / Shape: Point / Type of source: X-ray synchrotron / Wavelength: 0.123987 Å / Dist. spec. to detc.: 3 mm
DetectorName: Pilatus 1M-W / Pixsize x: 0.172 mm
Scan
Title: Disrupted-in-Schizophrenia 1 protein (DISC1 12d2) / Measurement date: Oct 1, 2015 / Storage temperature: 20 °C / Cell temperature: 20 °C / Exposure time: 0.095 sec. / Number of frames: 20 / Unit: 1/nm /
MinMax
Q0.049 4.8097
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 1115 /
MinMax
Q0.0833552 3.02809
P(R) point1 1115
R0 7.26
Result
Type of curve: single_conc
ExperimentalStandardPorod
MW17.31 kDa17.31 kDa24.1 kDa
Volume--40.9 nm3

P(R)GuinierGuinier error
Forward scattering, I0444.6 461.76 1.15
Radius of gyration, Rg2.512 nm2.64 nm0.1

MinMax
D-7.26
Guinier point14 168

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