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Yorodumi- PDB-8ei6: Crystal structure of the WWP2 HECT domain in complex with H305, a... -
+Open data
-Basic information
Entry | Database: PDB / ID: 8ei6 | ||||||
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Title | Crystal structure of the WWP2 HECT domain in complex with H305, a Helicon Polypeptide | ||||||
Components |
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Keywords | LIGASE / E3 ligase / complex / stapled peptide | ||||||
Function / homology | Function and homology information negative regulation of protein transport / extracellular transport / regulation of potassium ion transmembrane transporter activity / HECT-type E3 ubiquitin transferase / negative regulation of transporter activity / regulation of monoatomic ion transmembrane transport / negative regulation of Notch signaling pathway / RHOJ GTPase cycle / RHOQ GTPase cycle / protein K63-linked ubiquitination ...negative regulation of protein transport / extracellular transport / regulation of potassium ion transmembrane transporter activity / HECT-type E3 ubiquitin transferase / negative regulation of transporter activity / regulation of monoatomic ion transmembrane transport / negative regulation of Notch signaling pathway / RHOJ GTPase cycle / RHOQ GTPase cycle / protein K63-linked ubiquitination / transcription factor binding / RHOU GTPase cycle / protein autoubiquitination / ubiquitin ligase complex / NOTCH3 Activation and Transmission of Signal to the Nucleus / regulation of membrane potential / protein modification process / negative regulation of DNA-binding transcription factor activity / Regulation of PTEN stability and activity / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / proteasome-mediated ubiquitin-dependent protein catabolic process / RNA polymerase II-specific DNA-binding transcription factor binding / transcription by RNA polymerase II / protein ubiquitination / symbiont entry into host cell / negative regulation of gene expression / negative regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / extracellular exosome / membrane / nucleus / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) synthetic construct (others) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.62 Å | ||||||
Authors | Li, K. / Tokareva, O.S. / Thomson, T.M. / Verdine, G.L. / McGee, J.H. | ||||||
Funding support | United States, 1items
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Citation | Journal: Nat Commun / Year: 2023 Title: Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Authors: Tokareva, O.S. / Li, K. / Travaline, T.L. / Thomson, T.M. / Swiecicki, J.M. / Moussa, M. / Ramirez, J.D. / Litchman, S. / Verdine, G.L. / McGee, J.H. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 8ei6.cif.gz | 174.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb8ei6.ent.gz | 136.8 KB | Display | PDB format |
PDBx/mmJSON format | 8ei6.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 8ei6_validation.pdf.gz | 468.1 KB | Display | wwPDB validaton report |
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Full document | 8ei6_full_validation.pdf.gz | 483.4 KB | Display | |
Data in XML | 8ei6_validation.xml.gz | 29.6 KB | Display | |
Data in CIF | 8ei6_validation.cif.gz | 39.4 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ei/8ei6 ftp://data.pdbj.org/pub/pdb/validation_reports/ei/8ei6 | HTTPS FTP |
-Related structure data
Related structure data | 8ehzC 8ei0C 8ei1C 8ei2C 8ei3C 8ei4C 8ei5C 8ei7C 8ei8C 8ei9C 8eiaC 8eibC 8eicC 4y07S S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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