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Yorodumi- PDB-8ei1: Crystal structure of the N-terminal domain of CUL4B in complex wi... -
+Open data
-Basic information
Entry | Database: PDB / ID: 8ei1 | ||||||
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Title | Crystal structure of the N-terminal domain of CUL4B in complex with H316, a Helicon Polypeptide | ||||||
Components |
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Keywords | LIGASE / E3 ligase / complex / stapled peptide | ||||||
Function / homology | Function and homology information astrocyte differentiation / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / Cul4A-RING E3 ubiquitin ligase complex / Cul4B-RING E3 ubiquitin ligase complex / proteasomal protein catabolic process / positive regulation of G1/S transition of mitotic cell cycle / Recognition of DNA damage by PCNA-containing replication complex / DNA Damage Recognition in GG-NER / Transcription-Coupled Nucleotide Excision Repair (TC-NER) ...astrocyte differentiation / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / Cul4A-RING E3 ubiquitin ligase complex / Cul4B-RING E3 ubiquitin ligase complex / proteasomal protein catabolic process / positive regulation of G1/S transition of mitotic cell cycle / Recognition of DNA damage by PCNA-containing replication complex / DNA Damage Recognition in GG-NER / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / Formation of TC-NER Pre-Incision Complex / Dual Incision in GG-NER / Formation of Incision Complex in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / protein polyubiquitination / positive regulation of protein catabolic process / G1/S transition of mitotic cell cycle / cellular response to UV / neuron projection development / ribosome biogenesis / Neddylation / gene expression / ubiquitin-dependent protein catabolic process / protein ubiquitination / ubiquitin protein ligase binding / DNA damage response / extracellular exosome / nucleoplasm / nucleus / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) synthetic construct (others) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.89 Å | ||||||
Authors | Li, K. / Tokareva, O.S. / Thomson, T.M. / Verdine, G.L. / McGee, J.H. | ||||||
Funding support | United States, 1items
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Citation | Journal: Nat Commun / Year: 2023 Title: Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides. Authors: Tokareva, O.S. / Li, K. / Travaline, T.L. / Thomson, T.M. / Swiecicki, J.M. / Moussa, M. / Ramirez, J.D. / Litchman, S. / Verdine, G.L. / McGee, J.H. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 8ei1.cif.gz | 581.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb8ei1.ent.gz | 486.4 KB | Display | PDB format |
PDBx/mmJSON format | 8ei1.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ei/8ei1 ftp://data.pdbj.org/pub/pdb/validation_reports/ei/8ei1 | HTTPS FTP |
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-Related structure data
Related structure data | 8ehzC 8ei0C 8ei2C 8ei3C 8ei4C 8ei5C 8ei6C 8ei7C 8ei8C 8ei9C 8eiaC 8eibC 8eicC 4a64S S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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