登録情報 | データベース: PDB / ID: 7wr5 |
---|
タイトル | Crystal structure of OspC3-calmodulin-caspase-4 complex binding with 2'-aF-NAD+ |
---|
要素 | - Calmodulin-1
- Caspase-4
- OspC3
|
---|
キーワード | TRANSFERASE / ADP-riboxanase / effector |
---|
機能・相同性 | 機能・相同性情報
symbiont-mediated suppression of host signal transduction pathway / modulation by symbiont of defense-related host calcium ion flux / symbiont-mediated suppression of host calcium or calmodulin-mediated signal transduction / caspase-4 / symbiont-mediated suppression of host programmed cell death / Lyases; Carbon-nitrogen lyases; Other carbon-nitrogen lyases / ADP-riboxanase activity / non-canonical inflammasome complex / positive regulation of interleukin-18-mediated signaling pathway / symbiont-mediated perturbation of host programmed cell death ...symbiont-mediated suppression of host signal transduction pathway / modulation by symbiont of defense-related host calcium ion flux / symbiont-mediated suppression of host calcium or calmodulin-mediated signal transduction / caspase-4 / symbiont-mediated suppression of host programmed cell death / Lyases; Carbon-nitrogen lyases; Other carbon-nitrogen lyases / ADP-riboxanase activity / non-canonical inflammasome complex / positive regulation of interleukin-18-mediated signaling pathway / symbiont-mediated perturbation of host programmed cell death / non-canonical inflammasome complex assembly / AIM2 inflammasome complex / IPAF inflammasome complex / NLRP1 inflammasome complex / NLRP3 inflammasome complex / CARD domain binding / caspase binding / positive regulation of tumor necrosis factor-mediated signaling pathway / CaM pathway / Cam-PDE 1 activation / Sodium/Calcium exchangers / Calmodulin induced events / Reduction of cytosolic Ca++ levels / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Activation of Ca-permeable Kainate Receptor / Loss of phosphorylation of MECP2 at T308 / CREB1 phosphorylation through the activation of Adenylate Cyclase / PKA activation / negative regulation of high voltage-gated calcium channel activity / CaMK IV-mediated phosphorylation of CREB / Glycogen breakdown (glycogenolysis) / positive regulation of cyclic-nucleotide phosphodiesterase activity / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / CLEC7A (Dectin-1) induces NFAT activation / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / Activation of RAC1 downstream of NMDARs / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of cell communication by electrical coupling involved in cardiac conduction / Negative regulation of NMDA receptor-mediated neuronal transmission / negative regulation of peptidyl-threonine phosphorylation / Synthesis of IP3 and IP4 in the cytosol / Unblocking of NMDA receptors, glutamate binding and activation / pyroptotic inflammatory response / Phase 0 - rapid depolarisation / protein phosphatase activator activity / RHO GTPases activate PAKs / positive regulation of phosphoprotein phosphatase activity / Ion transport by P-type ATPases / Long-term potentiation / Uptake and function of anthrax toxins / protein autoprocessing / protein maturation / Calcineurin activates NFAT / Regulation of MECP2 expression and activity / catalytic complex / DARPP-32 events / detection of calcium ion / regulation of cardiac muscle contraction / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / negative regulation of ryanodine-sensitive calcium-release channel activity / Smooth Muscle Contraction / RHO GTPases activate IQGAPs / calcium channel inhibitor activity / cellular response to interferon-beta / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / Pyroptosis / Protein methylation / eNOS activation / Activation of AMPK downstream of NMDARs / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / positive regulation of protein dephosphorylation / Ion homeostasis / regulation of calcium-mediated signaling / regulation of ryanodine-sensitive calcium-release channel activity / titin binding / positive regulation of protein autophosphorylation / voltage-gated potassium channel complex / sperm midpiece / calcium channel complex / substantia nigra development / adenylate cyclase activator activity / Ras activation upon Ca2+ influx through NMDA receptor / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / FCERI mediated Ca+2 mobilization / intrinsic apoptotic signaling pathway / FCGR3A-mediated IL10 synthesis / VEGFR2 mediated vascular permeability / positive regulation of peptidyl-threonine phosphorylation / regulation of cytokinesis / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / VEGFR2 mediated cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / lipopolysaccharide binding / positive regulation of receptor signaling pathway via JAK-STAT類似検索 - 分子機能 Arginine ADP-riboxanase OspC1-3 / Shigella flexneri OspC protein / Caspase recruitment domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site ...Arginine ADP-riboxanase OspC1-3 / Shigella flexneri OspC protein / Caspase recruitment domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Death-like domain superfamily / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair類似検索 - ドメイン・相同性 Chem-5ZV / Calmodulin-1 / Caspase-4 / Arginine ADP-riboxanase OspC3類似検索 - 構成要素 |
---|
生物種 | Shigella flexneri (フレクスナー赤痢菌) Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.1 Å |
---|
データ登録者 | Hou, Y.J. / Zeng, H. / Shao, F. / Ding, J. |
---|
資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
---|
Chinese Academy of Sciences | | 中国 |
|
---|
引用 | ジャーナル: Nat.Struct.Mol.Biol. / 年: 2023 タイトル: Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. 著者: Hou, Y. / Zeng, H. / Li, Z. / Feng, N. / Meng, F. / Xu, Y. / Li, L. / Shao, F. / Ding, J. |
---|
履歴 | 登録 | 2022年1月26日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2023年1月25日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年2月1日 | Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title |
---|
改定 1.2 | 2023年3月29日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
---|
改定 1.3 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|