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Yorodumi- PDB-7vyt: Crystal structure of human TIGIT(23-129) in complex with the scFv... -
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-Basic information
Entry | Database: PDB / ID: 7vyt | ||||||
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Title | Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131 | ||||||
Components |
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Keywords | IMMUNE SYSTEM / Antibody / Immune Checkpoint / TIGIT | ||||||
Function / homology | Function and homology information negative regulation of T cell activation / negative regulation of interleukin-12 production / positive regulation of interleukin-10 production / signaling receptor binding / cell surface / identical protein binding / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.53 Å | ||||||
Authors | Jeong, B.-S. / Nam, H. / Kim, M. / Oh, B.-H. | ||||||
Funding support | Korea, Republic Of, 1items
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Citation | Journal: Mabs / Year: 2022 Title: Structural and functional characterization of a monoclonal antibody blocking TIGIT. Authors: Jeong, B.S. / Nam, H. / Lee, J. / Park, H.Y. / Cho, K.J. / Sheen, J.H. / Song, E. / Oh, M. / Lee, S. / Choi, H. / Yang, J.E. / Kim, M. / Oh, B.H. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7vyt.cif.gz | 165.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7vyt.ent.gz | 115.6 KB | Display | PDB format |
PDBx/mmJSON format | 7vyt.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/vy/7vyt ftp://data.pdbj.org/pub/pdb/validation_reports/vy/7vyt | HTTPS FTP |
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-Related structure data
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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