登録情報 | データベース: PDB / ID: 7t5f |
---|
タイトル | Botulinum neurotoxin Type B Light Chain complexed with nanobodies JLJ-G3 and JNE-B10 |
---|
要素 | - Botulinum neurotoxin type B
- JLJ-G3
- JNE-B10
|
---|
キーワード | TOXIN / Botulinum neurotoxin / camelid heavy chain antibody / endopeptidase / inhibitor |
---|
機能・相同性 | 機能・相同性情報
Toxicity of botulinum toxin type B (botB) / bontoxilysin / host cell presynaptic membrane / host cell cytoplasmic vesicle / host cell cytosol / protein transmembrane transporter activity / metalloendopeptidase activity / toxin activity / lipid binding / host cell plasma membrane ...Toxicity of botulinum toxin type B (botB) / bontoxilysin / host cell presynaptic membrane / host cell cytoplasmic vesicle / host cell cytosol / protein transmembrane transporter activity / metalloendopeptidase activity / toxin activity / lipid binding / host cell plasma membrane / proteolysis / zinc ion binding / extracellular region / membrane類似検索 - 分子機能 Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain / Clostridium neurotoxin, translocation domain / Clostridial neurotoxin zinc protease / Botulinum/Tetanus toxin, catalytic chain / Clostridium neurotoxin, receptor binding N-terminal / Clostridium neurotoxin, receptor-binding C-terminal / Clostridium neurotoxin, C-terminal receptor binding / Clostridium neurotoxin, N-terminal receptor binding / Kunitz inhibitor STI-like superfamily ...Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain / Clostridium neurotoxin, translocation domain / Clostridial neurotoxin zinc protease / Botulinum/Tetanus toxin, catalytic chain / Clostridium neurotoxin, receptor binding N-terminal / Clostridium neurotoxin, receptor-binding C-terminal / Clostridium neurotoxin, C-terminal receptor binding / Clostridium neurotoxin, N-terminal receptor binding / Kunitz inhibitor STI-like superfamily / Neutral zinc metallopeptidases, zinc-binding region signature. / Concanavalin A-like lectin/glucanase domain superfamily類似検索 - ドメイン・相同性 |
---|
生物種 | ![](img/tx_bacteria.gif) Clostridium botulinum (ボツリヌス菌)
Camelidae (哺乳類) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.6 Å |
---|
データ登録者 | Jin, R. / Lam, K.-H. |
---|
資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | 1R01AI125704 | 米国 |
|
---|
引用 | ジャーナル: Plos Pathog. / 年: 2022 タイトル: Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. 著者: Lam, K.H. / Tremblay, J.M. / Perry, K. / Ichtchenko, K. / Shoemaker, C.B. / Jin, R. |
---|
履歴 | 登録 | 2021年12月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2021年12月29日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2022年1月19日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
---|
改定 1.2 | 2024年4月3日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|