+Open data
-Basic information
Entry | Database: PDB / ID: 7s5a | ||||||
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Title | Crystal structure of human chemokine CCL8 | ||||||
Components | C-C motif chemokine 8 | ||||||
Keywords | CYTOKINE / CC Chemokine | ||||||
Function / homology | Function and homology information CCR2 chemokine receptor binding / negative regulation of leukocyte proliferation / negative regulation by host of viral genome replication / CCR chemokine receptor binding / lymphocyte chemotaxis / eosinophil chemotaxis / chemokine-mediated signaling pathway / chemokine activity / positive regulation of leukocyte migration / phospholipase activator activity ...CCR2 chemokine receptor binding / negative regulation of leukocyte proliferation / negative regulation by host of viral genome replication / CCR chemokine receptor binding / lymphocyte chemotaxis / eosinophil chemotaxis / chemokine-mediated signaling pathway / chemokine activity / positive regulation of leukocyte migration / phospholipase activator activity / exocytosis / monocyte chemotaxis / cellular response to interleukin-1 / neutrophil chemotaxis / response to virus / cellular response to type II interferon / intracellular calcium ion homeostasis / calcium ion transport / chemotaxis / cell-cell signaling / cellular response to tumor necrosis factor / heparin binding / angiogenesis / positive regulation of ERK1 and ERK2 cascade / protein kinase activity / inflammatory response / G protein-coupled receptor signaling pathway / signal transduction / extracellular space Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.37 Å | ||||||
Authors | Bhusal, R.P. / Devkota, S.R. / Aryal, P. / Wilce, M.C.J. / Stone, M.J. | ||||||
Funding support | Australia, 1items
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2022 Title: Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases. Authors: Bhusal, R.P. / Aryal, P. / Devkota, S.R. / Pokhrel, R. / Gunzburg, M.J. / Foster, S.R. / Lim, H.D. / Payne, R.J. / Wilce, M.C.J. / Stone, M.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7s5a.cif.gz | 96.7 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7s5a.ent.gz | 60.9 KB | Display | PDB format |
PDBx/mmJSON format | 7s5a.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7s5a_validation.pdf.gz | 407.8 KB | Display | wwPDB validaton report |
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Full document | 7s5a_full_validation.pdf.gz | 407.8 KB | Display | |
Data in XML | 7s5a_validation.xml.gz | 10 KB | Display | |
Data in CIF | 7s5a_validation.cif.gz | 14.4 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/s5/7s5a ftp://data.pdbj.org/pub/pdb/validation_reports/s5/7s5a | HTTPS FTP |
-Related structure data
Related structure data | 7s4nC 7s58C 7s59C 7so0C 1esrS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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