Entry Database : PDB / ID : 7pje Structure visualization Downloads & linksTitle Inhibiting parasite proliferation using a rationally designed anti-tubulin agent ComponentsDarpin D1 Tubulin alpha chain Tubulin beta chain DetailsKeywords STRUCTURAL PROTEIN / Tubulin / Microtubules / Protozoa / ApicomplexaFunction / homology Function and homology informationFunction Domain/homology Component
Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / structural constituent of cytoskeleton / microtubule cytoskeleton organization / mitotic cell cycle / microtubule / hydrolase activity / GTPase activity / GTP binding / metal ion binding / cytoplasm Similarity search - Function Alpha tubulin / Tubulin-beta mRNA autoregulation signal. / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature. / Tubulin/FtsZ family, C-terminal domain ... Alpha tubulin / Tubulin-beta mRNA autoregulation signal. / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tubulin/FtsZ, C-terminal / Tubulin/FtsZ, 2-layer sandwich domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ, GTPase domain / Tubulin/FtsZ, GTPase domain superfamily Similarity search - Domain/homologyBiological species synthetic construct (others) Tetrahymena thermophila (eukaryote)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.75 Å DetailsAuthors Sharma, A. / Gaillard, N. / Ehrhard, V.A. / Steinmetz, M.O. Funding support Switzerland, 1items Details Hide detailsOrganization Grant number Country Novartis FreeNovation Switzerland
CitationJournal : Embo Mol Med / Year : 2021Title : Inhibiting parasite proliferation using a rationally designed anti-tubulin agent.Authors : Gaillard, N. / Sharma, A. / Abbaali, I. / Liu, T. / Shilliday, F. / Cook, A.D. / Ehrhard, V. / Bangera, M. / Roberts, A.J. / Moores, C.A. / Morrissette, N. / Steinmetz, M.O. History Deposition Aug 24, 2021 Deposition site : PDBE / Processing site : PDBERevision 1.0 Sep 22, 2021 Provider : repository / Type : Initial releaseRevision 2.0 Nov 3, 2021 Group : Atomic model / Data collection / Database referencesCategory : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / citation / citation_author / pdbx_data_processing_status / pdbx_database_proc Item : _atom_site_anisotrop.id / _citation.page_first ... _atom_site_anisotrop.id / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name Revision 2.1 Nov 17, 2021 Group : Data collection / Database referencesCategory : citation / database_PDB_rev ... citation / database_PDB_rev / database_PDB_rev_record / pdbx_database_proc Item : _citation.journal_volumeRevision 2.2 Jan 31, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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