登録情報 データベース : PDB / ID : 7p5k 構造の表示 ダウンロードとリンクタイトル Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 interaction 要素Kelch-like ECH-associated protein 1 詳細 キーワード PROTEIN BINDING / protein ubiquitination / protein-protein interaction / oxidative stress機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cellular response to carbohydrate stimulus / KEAP1-NFE2L2 pathway / regulation of epidermal cell differentiation / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Ub-specific processing proteases / negative regulation of response to oxidative stress / Cul3-RING ubiquitin ligase complex / ubiquitin-like ligase-substrate adaptor activity / centriolar satellite ... cellular response to carbohydrate stimulus / KEAP1-NFE2L2 pathway / regulation of epidermal cell differentiation / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Ub-specific processing proteases / negative regulation of response to oxidative stress / Cul3-RING ubiquitin ligase complex / ubiquitin-like ligase-substrate adaptor activity / centriolar satellite / cellular response to interleukin-4 / inclusion body / regulation of autophagy / actin filament / adherens junction / disordered domain specific binding / midbody / cellular response to oxidative stress / ubiquitin-dependent protein catabolic process / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / protein ubiquitination / negative regulation of gene expression / focal adhesion / regulation of DNA-templated transcription / endoplasmic reticulum / protein-containing complex / nucleoplasm / identical protein binding / cytoplasm / cytosol 類似検索 - 分子機能 Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif / Kelch-type beta propeller ... Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif / Kelch-type beta propeller / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / SKP1/BTB/POZ domain superfamily 類似検索 - ドメイン・相同性 Chem-5UZ / Kelch-like ECH-associated protein 1 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ)手法 X線回折 / フーリエ合成 / 解像度 : 1.79 Å 詳細データ登録者 Davies, T.G. 引用ジャーナル : J.Med.Chem. / 年 : 2021タイトル : Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.著者: Norton, D. / Bonnette, W.G. / Callahan, J.F. / Carr, M.G. / Griffiths-Jones, C.M. / Heightman, T.D. / Kerns, J.K. / Nie, H. / Rich, S.J. / Richardson, C. / Rumsey, W. / Sanchez, Y. / Verdonk, ... 著者 : Norton, D. / Bonnette, W.G. / Callahan, J.F. / Carr, M.G. / Griffiths-Jones, C.M. / Heightman, T.D. / Kerns, J.K. / Nie, H. / Rich, S.J. / Richardson, C. / Rumsey, W. / Sanchez, Y. / Verdonk, M.L. / Willems, H.M.G. / Wixted, W.E. / Wolfe 3rd, L. / Woolford, A.J. / Wu, Z. / Davies, T.G. 履歴 登録 2021年7月14日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2021年11月17日 Provider : repository / タイプ : Initial release改定 1.1 2021年11月24日 Group : Data collection / Database referencesカテゴリ : citation / citation_author / pdbx_database_procItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID 改定 1.2 2024年6月19日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond
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