Entry Database : PDB / ID : 4zy3 Structure visualization Downloads & linksTitle Crystal Structure of Keap1 in Complex with a small chemical compound, K67 ComponentsKelch-like ECH-associated protein 1 Details Keywords TRANSCRIPTION / Nrf2 / Keap1 / Stress sensor / Small molecule binding / Double glycine repeat / Kelch domain / p62Function / homology Function and homology informationFunction Domain/homology Component
cellular response to carbohydrate stimulus / KEAP1-NFE2L2 pathway / regulation of epidermal cell differentiation / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Ub-specific processing proteases / negative regulation of response to oxidative stress / Cul3-RING ubiquitin ligase complex / centriolar satellite / ubiquitin-like ligase-substrate adaptor activity ... cellular response to carbohydrate stimulus / KEAP1-NFE2L2 pathway / regulation of epidermal cell differentiation / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Ub-specific processing proteases / negative regulation of response to oxidative stress / Cul3-RING ubiquitin ligase complex / centriolar satellite / ubiquitin-like ligase-substrate adaptor activity / cellular response to interleukin-4 / inclusion body / regulation of autophagy / actin filament / adherens junction / disordered domain specific binding / cellular response to oxidative stress / midbody / ubiquitin-dependent protein catabolic process / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / protein ubiquitination / negative regulation of gene expression / focal adhesion / regulation of DNA-templated transcription / endoplasmic reticulum / protein-containing complex / nucleoplasm / identical protein binding / cytosol / cytoplasm Similarity search - Function Kelch-type beta propeller / Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif ... Kelch-type beta propeller / Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif / Kelch-type beta propeller / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / 6 Propeller / Neuraminidase / SKP1/BTB/POZ domain superfamily / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.8 Å DetailsAuthors Fukutomi, T. / Iso, T. / Suzuki, T. / Takagi, K. / Mizushima, T. / Komatsu, M. / Yamamoto, M. CitationJournal : Nat Commun / Year : 2016Title : p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogrammingAuthors: Saito, T. / Ichimura, Y. / Taguchi, K. / Suzuki, T. / Mizushima, T. / Takagi, K. / Hirose, Y. / Nagahashi, M. / Iso, T. / Fukutomi, T. / Ohishi, M. / Endo, K. / Uemura, T. / Nishito, Y. / ... Authors : Saito, T. / Ichimura, Y. / Taguchi, K. / Suzuki, T. / Mizushima, T. / Takagi, K. / Hirose, Y. / Nagahashi, M. / Iso, T. / Fukutomi, T. / Ohishi, M. / Endo, K. / Uemura, T. / Nishito, Y. / Okuda, S. / Obata, M. / Kouno, T. / Imamura, R. / Tada, Y. / Obata, R. / Yasuda, D. / Takahashi, K. / Fujimura, T. / Pi, J. / Lee, M.S. / Ueno, T. / Ohe, T. / Mashino, T. / Wakai, T. / Kojima, H. / Okabe, T. / Nagano, T. / Motohashi, H. / Waguri, S. / Soga, T. / Yamamoto, M. / Tanaka, K. / Komatsu, M. History Deposition May 21, 2015 Deposition site : RCSB / Processing site : PDBJRevision 1.0 May 25, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2016 Group : Database referencesRevision 1.2 Feb 19, 2020 Group : Data collection / Derived calculations / Category : diffrn_source / pdbx_struct_oper_listItem : _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operationRevision 1.3 Nov 8, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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