+Open data
-Basic information
Entry | Database: PDB / ID: 7opo | |||||||||
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Title | RSK2 N-terminal kinase domain in complex with ORF45 | |||||||||
Components |
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Keywords | VIRAL PROTEIN / ORF45 / RSK2 / RSK / RSK2 NTK / Viral modulation / MAPKAPK / Kaposi's sarcoma-associated herpesvirus / VF-motif | |||||||||
Function / homology | Function and homology information regulation of translation in response to stress / CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling / symbiont-mediated perturbation of host innate immune response / ribosomal protein S6 kinase activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity / CREB phosphorylation / viral tegument / Gastrin-CREB signalling pathway via PKC and MAPK / RSK activation / toll-like receptor signaling pathway ...regulation of translation in response to stress / CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling / symbiont-mediated perturbation of host innate immune response / ribosomal protein S6 kinase activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity / CREB phosphorylation / viral tegument / Gastrin-CREB signalling pathway via PKC and MAPK / RSK activation / toll-like receptor signaling pathway / Recycling pathway of L1 / ERK/MAPK targets / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / central nervous system development / skeletal system development / positive regulation of cell differentiation / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / Senescence-Associated Secretory Phenotype (SASP) / chemical synaptic transmission / host cell Golgi apparatus / positive regulation of cell growth / peptidyl-serine phosphorylation / response to lipopolysaccharide / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / cell cycle / protein serine kinase activity / protein serine/threonine kinase activity / synapse / host cell nucleus / nucleolus / negative regulation of apoptotic process / protein kinase binding / magnesium ion binding / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / cytosol / cytoplasm Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) Human herpesvirus 8 | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.75 Å | |||||||||
Authors | Sok, P. / Remenyi, A. / Alexa, A. / Poti, A. | |||||||||
Funding support | Hungary, European Union, 2items
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Citation | Journal: Nat Commun / Year: 2022 Title: A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host. Authors: Alexa, A. / Sok, P. / Gross, F. / Albert, K. / Kobori, E. / Poti, A.L. / Gogl, G. / Bento, I. / Kuang, E. / Taylor, S.S. / Zhu, F. / Ciliberto, A. / Remenyi, A. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7opo.cif.gz | 880.7 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7opo.ent.gz | 702.7 KB | Display | PDB format |
PDBx/mmJSON format | 7opo.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/op/7opo ftp://data.pdbj.org/pub/pdb/validation_reports/op/7opo | HTTPS FTP |
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-Related structure data
Related structure data | 7opmC 3g51S S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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