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Yorodumi- PDB-7lon: Ornithine Aminotransferase (OAT) cocrystallized with its inactiva... -
+Open data
-Basic information
Entry | Database: PDB / ID: 7lon | ||||||
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Title | Ornithine Aminotransferase (OAT) cocrystallized with its inactivator - (1S,3S)-3-amino-4-(difluoromethylene)cyclohexene-1-carboxylic acid | ||||||
Components | Ornithine aminotransferase, mitochondrial | ||||||
Keywords | TRANSFERASE / Ornithine Aminotransferase / OAT / aminotransferase / inactivator / inhibitor | ||||||
Function / homology | Function and homology information arginine catabolic process to proline via ornithine / ornithine aminotransferase activity / ornithine aminotransferase / arginine catabolic process to glutamate / L-proline biosynthetic process / Glutamate and glutamine metabolism / visual perception / pyridoxal phosphate binding / mitochondrial matrix / mitochondrion ...arginine catabolic process to proline via ornithine / ornithine aminotransferase activity / ornithine aminotransferase / arginine catabolic process to glutamate / L-proline biosynthetic process / Glutamate and glutamine metabolism / visual perception / pyridoxal phosphate binding / mitochondrial matrix / mitochondrion / nucleoplasm / identical protein binding / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.95 Å | ||||||
Authors | Butrin, A. / Zhu, W. / Liu, D. / Silverman, R. | ||||||
Funding support | United States, 1items
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Citation | Journal: J.Am.Chem.Soc. / Year: 2021 Title: Remarkable and Unexpected Mechanism for ( S )-3-Amino-4-(difluoromethylenyl)cyclohex-1-ene-1-carboxylic Acid as a Selective Inactivator of Human Ornithine Aminotransferase. Authors: Zhu, W. / Doubleday, P.F. / Butrin, A. / Weerawarna, P.M. / Melani, R.D. / Catlin, D.S. / Dwight, T.A. / Liu, D. / Kelleher, N.L. / Silverman, R.B. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7lon.cif.gz | 496.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7lon.ent.gz | 410 KB | Display | PDB format |
PDBx/mmJSON format | 7lon.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7lon_validation.pdf.gz | 2.4 MB | Display | wwPDB validaton report |
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Full document | 7lon_full_validation.pdf.gz | 2.4 MB | Display | |
Data in XML | 7lon_validation.xml.gz | 51.7 KB | Display | |
Data in CIF | 7lon_validation.cif.gz | 73.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/lo/7lon ftp://data.pdbj.org/pub/pdb/validation_reports/lo/7lon | HTTPS FTP |
-Related structure data
Related structure data | 7lnmC 7lomC 1oatS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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