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- PDB-7lo0: Structure of human ASF1a in complex with a TLK2 peptide -

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Basic information

Entry
Database: PDB / ID: 7lo0
TitleStructure of human ASF1a in complex with a TLK2 peptide
Components
  • Histone chaperone ASF1A
  • Serine/threonine-protein kinase tousled-like 2
KeywordsCELL CYCLE / histone chaperone / kinase / docking / nucleosome assembly
Function / homology
Function and homology information


nucleus localization / histone chaperone activity / regulation of chromatin organization / DNA replication-dependent chromatin assembly / muscle cell differentiation / intermediate filament / Formation of Senescence-Associated Heterochromatin Foci (SAHF) / DNA repair-dependent chromatin remodeling / replication fork processing / negative regulation of proteasomal ubiquitin-dependent protein catabolic process ...nucleus localization / histone chaperone activity / regulation of chromatin organization / DNA replication-dependent chromatin assembly / muscle cell differentiation / intermediate filament / Formation of Senescence-Associated Heterochromatin Foci (SAHF) / DNA repair-dependent chromatin remodeling / replication fork processing / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / negative regulation of autophagy / chromosome segregation / cellular response to gamma radiation / nucleosome assembly / osteoblast differentiation / site of double-strand break / peptidyl-serine phosphorylation / histone binding / eukaryotic translation initiation factor 2alpha kinase activity / 3-phosphoinositide-dependent protein kinase activity / DNA-dependent protein kinase activity / ribosomal protein S6 kinase activity / histone H3S10 kinase activity / histone H2AXS139 kinase activity / histone H3S28 kinase activity / histone H4S1 kinase activity / histone H2BS14 kinase activity / histone H3T3 kinase activity / histone H2AS121 kinase activity / Rho-dependent protein serine/threonine kinase activity / histone H2BS36 kinase activity / histone H3S57 kinase activity / histone H2AT120 kinase activity / AMP-activated protein kinase activity / histone H2AS1 kinase activity / histone H3T6 kinase activity / histone H3T11 kinase activity / histone H3T45 kinase activity / non-specific serine/threonine protein kinase / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / DNA repair / protein serine/threonine kinase activity / DNA damage response / chromatin binding / chromatin / perinuclear region of cytoplasm / protein-containing complex / nucleoplasm / ATP binding / identical protein binding / nucleus
Similarity search - Function
Histone chaperone ASF1-like / Histone chaperone ASF1-like superfamily / ASF1 like histone chaperone / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. ...Histone chaperone ASF1-like / Histone chaperone ASF1-like superfamily / ASF1 like histone chaperone / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily
Similarity search - Domain/homology
Serine/threonine-protein kinase tousled-like 2 / Histone chaperone ASF1A
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.71 Å
AuthorsSimon, B. / Calderwood, D. / Turk, B.E. / Boggon, T.J.
Funding support United States, 3items
OrganizationGrant numberCountry
National Institutes of Health/National Center for Advancing Translational Sciences (NIH/NCATS)1R03TR002912-01 United States
American Heart Association18POST33960340 United States
National Institutes of Health/National Cancer Institute (NIH/NCI)5P50 CA196530 United States
CitationJournal: Nat Commun / Year: 2022
Title: Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Authors: Simon, B. / Lou, H.J. / Huet-Calderwood, C. / Shi, G. / Boggon, T.J. / Turk, B.E. / Calderwood, D.A.
History
DepositionFeb 8, 2021Deposition site: RCSB / Processing site: RCSB
Revision 1.0Feb 16, 2022Provider: repository / Type: Initial release
Revision 1.1Oct 18, 2023Group: Data collection / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model / struct_ncs_dom_lim
Item: _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id ..._struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Histone chaperone ASF1A
B: Histone chaperone ASF1A
C: Histone chaperone ASF1A
D: Histone chaperone ASF1A
E: Histone chaperone ASF1A
F: Histone chaperone ASF1A
G: Histone chaperone ASF1A
H: Histone chaperone ASF1A
I: Serine/threonine-protein kinase tousled-like 2
J: Serine/threonine-protein kinase tousled-like 2
K: Serine/threonine-protein kinase tousled-like 2
L: Serine/threonine-protein kinase tousled-like 2
M: Serine/threonine-protein kinase tousled-like 2
N: Serine/threonine-protein kinase tousled-like 2
O: Serine/threonine-protein kinase tousled-like 2
P: Serine/threonine-protein kinase tousled-like 2
Q: Serine/threonine-protein kinase tousled-like 2
R: Serine/threonine-protein kinase tousled-like 2
T: Serine/threonine-protein kinase tousled-like 2
U: Serine/threonine-protein kinase tousled-like 2
V: Serine/threonine-protein kinase tousled-like 2
W: Serine/threonine-protein kinase tousled-like 2
X: Serine/threonine-protein kinase tousled-like 2
Y: Serine/threonine-protein kinase tousled-like 2


Theoretical massNumber of molelcules
Total (without water)182,63624
Polymers182,63624
Non-polymers00
Water2,990166
1
A: Histone chaperone ASF1A
I: Serine/threonine-protein kinase tousled-like 2
Q: Serine/threonine-protein kinase tousled-like 2


Theoretical massNumber of molelcules
Total (without water)22,8293
Polymers22,8293
Non-polymers00
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
B: Histone chaperone ASF1A
J: Serine/threonine-protein kinase tousled-like 2
R: Serine/threonine-protein kinase tousled-like 2


Theoretical massNumber of molelcules
Total (without water)22,8293
Polymers22,8293
Non-polymers00
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
C: Histone chaperone ASF1A
K: Serine/threonine-protein kinase tousled-like 2
T: Serine/threonine-protein kinase tousled-like 2


Theoretical massNumber of molelcules
Total (without water)22,8293
Polymers22,8293
Non-polymers00
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
D: Histone chaperone ASF1A
L: Serine/threonine-protein kinase tousled-like 2
U: Serine/threonine-protein kinase tousled-like 2


Theoretical massNumber of molelcules
Total (without water)22,8293
Polymers22,8293
Non-polymers00
Water543
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
5
E: Histone chaperone ASF1A
M: Serine/threonine-protein kinase tousled-like 2
V: Serine/threonine-protein kinase tousled-like 2


Theoretical massNumber of molelcules
Total (without water)22,8293
Polymers22,8293
Non-polymers00
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
6
F: Histone chaperone ASF1A
N: Serine/threonine-protein kinase tousled-like 2
W: Serine/threonine-protein kinase tousled-like 2


Theoretical massNumber of molelcules
Total (without water)22,8293
Polymers22,8293
Non-polymers00
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
7
G: Histone chaperone ASF1A
O: Serine/threonine-protein kinase tousled-like 2
X: Serine/threonine-protein kinase tousled-like 2


Theoretical massNumber of molelcules
Total (without water)22,8293
Polymers22,8293
Non-polymers00
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
8
H: Histone chaperone ASF1A
P: Serine/threonine-protein kinase tousled-like 2
Y: Serine/threonine-protein kinase tousled-like 2


Theoretical massNumber of molelcules
Total (without water)22,8293
Polymers22,8293
Non-polymers00
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)88.023, 136.681, 101.316
Angle α, β, γ (deg.)90.000, 103.220, 90.000
Int Tables number4
Space group name H-MP1211
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
11(chain A and resid 3 through 153)
21(chain B and resid 3 through 153)
31(chain C and resid 3 through 153)
41chain D
51(chain E and resid 3 through 153)
61(chain F and resid 3 through 153)
71(chain G and resid 3 through 153)
81(chain H and resid 3 through 153)
12(chain I and resid 9 through 22)
22(chain J and resid 9 through 22)
32(chain K and resid 9 through 22)
42(chain L and resid 9 through 22)
52(chain M and resid 9 through 22)
62chain O
72chain P
13chain Q
23(chain R and resid 11 through 17)
33chain T
43chain U
53chain V
63chain W
73chain X
83chain Y

NCS domain segments:

Component-ID: 1

Dom-IDEns-IDBeg auth comp-IDBeg label comp-IDEnd auth comp-IDEnd label comp-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11LYSLYSTRPTRP(chain A and resid 3 through 153)AA3 - 1535 - 155
21LYSLYSTRPTRP(chain B and resid 3 through 153)BB3 - 1535 - 155
31LYSLYSTRPTRP(chain C and resid 3 through 153)CC3 - 1535 - 155
41LYSLYSTRPTRPchain DDD3 - 1535 - 155
51LYSLYSTRPTRP(chain E and resid 3 through 153)EE3 - 1535 - 155
61LYSLYSTRPTRP(chain F and resid 3 through 153)FF3 - 1535 - 155
71LYSLYSTRPTRP(chain G and resid 3 through 153)GG3 - 1535 - 155
81LYSLYSTRPTRP(chain H and resid 3 through 153)HH3 - 1535 - 155
12ASPASPGLYGLY(chain I and resid 9 through 22)II9 - 227 - 20
22ASPASPGLYGLY(chain J and resid 9 through 22)JJ9 - 227 - 20
32ASPASPGLYGLY(chain K and resid 9 through 22)KK9 - 227 - 20
42ASPASPGLYGLY(chain L and resid 9 through 22)LL9 - 227 - 20
52ASPASPGLYGLY(chain M and resid 9 through 22)MM9 - 227 - 20
62ASPASPGLYGLYchain OOO9 - 227 - 20
72ASPASPGLYGLYchain PPP9 - 227 - 20
13ARGARGGLUGLUchain QQQ11 - 179 - 15
23ARGARGGLUGLU(chain R and resid 11 through 17)RR11 - 179 - 15
33ARGARGGLUGLUchain TTS11 - 179 - 15
43ARGARGGLUGLUchain UUT11 - 179 - 15
53ARGARGGLUGLUchain VVU11 - 179 - 15
63ARGARGGLUGLUchain WWV11 - 179 - 15
73ARGARGGLUGLUchain XXW11 - 179 - 15
83ARGARGGLUGLUchain YYX11 - 179 - 15

NCS ensembles :
ID
1
2
3

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Components

#1: Protein
Histone chaperone ASF1A / Anti-silencing function protein 1 homolog A / hAsf1 / hAsf1a / CCG1-interacting factor A / CIA / hCIA


Mass: 17829.896 Da / Num. of mol.: 8 / Fragment: Residues 1-155
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: ASF1A, CGI-98, HSPC146 / Production host: Escherichia coli (E. coli) / Strain (production host): Rosetta 2 / References: UniProt: Q9Y294
#2: Protein/peptide
Serine/threonine-protein kinase tousled-like 2 / HsHPK / PKU-alpha / Tousled-like kinase 2


Mass: 2499.777 Da / Num. of mol.: 16 / Fragment: Residues 3-23
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: TLK2 / Production host: Escherichia coli (E. coli) / Strain (production host): Rosetta 2
References: UniProt: Q86UE8, non-specific serine/threonine protein kinase
#3: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 166 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.25 Å3/Da / Density % sol: 62.2 %
Crystal growTemperature: 293 K / Method: vapor diffusion, hanging drop / pH: 5.6
Details: 18% PEG3350, 0.2 M of trisodium citrate, pH 5.6 and 2% Octyl-D-glucose

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 24-ID-C / Wavelength: 0.9792 Å
DetectorType: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Aug 17, 2019
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9792 Å / Relative weight: 1
ReflectionResolution: 2.71→98.63 Å / Num. obs: 62051 / % possible obs: 98 % / Redundancy: 3.2 % / Biso Wilson estimate: 53.44 Å2 / CC1/2: 0.998 / Rmerge(I) obs: 0.057 / Rpim(I) all: 0.037 / Rrim(I) all: 0.068 / Net I/σ(I): 10.9 / Num. measured all: 199527
Reflection shell

Diffraction-ID: 1

Resolution (Å)Redundancy (%)Rmerge(I) obsNum. measured allNum. unique obsCC1/2Rpim(I) allRrim(I) allNet I/σ(I) obs% possible all
2.71-2.7830.4391340244410.8630.2920.53296.1
12.12-98.633.40.02424607210.9980.0150.02827.296.3

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Phasing

PhasingMethod: molecular replacement
Phasing MR
Highest resolutionLowest resolution
Rotation2.45 Å98.63 Å
Translation2.45 Å98.63 Å

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Processing

Software
NameVersionClassification
PHENIX1.19refinement
XDSdata reduction
Aimless0.7.4data scaling
PHASER2.8.2phasing
PDB_EXTRACT3.25data extraction
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 2I32

2i32


Resolution: 2.71→98.63 Å / SU ML: 0.4 / Cross valid method: THROUGHOUT / σ(F): 1.35 / Phase error: 23.27 / Stereochemistry target values: ML
RfactorNum. reflection% reflectionSelection details
Rfree0.2256 6075 5.13 %0
Rwork0.213 112347 --
obs0.2137 62010 94.84 %-
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso max: 176.24 Å2 / Biso mean: 63.0621 Å2 / Biso min: 22.61 Å2
Refinement stepCycle: final / Resolution: 2.71→98.63 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms11382 0 0 166 11548
Biso mean---47.38 -
Num. residues----1401
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00211647
X-RAY DIFFRACTIONf_angle_d0.51215864
X-RAY DIFFRACTIONf_dihedral_angle_d13.8424338
X-RAY DIFFRACTIONf_chiral_restr0.0471746
X-RAY DIFFRACTIONf_plane_restr0.0052118
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDNumberRefine-IDRmsType
11A5981X-RAY DIFFRACTION12.571TORSIONAL
12B5981X-RAY DIFFRACTION12.571TORSIONAL
13C5981X-RAY DIFFRACTION12.571TORSIONAL
14D5981X-RAY DIFFRACTION12.571TORSIONAL
15E5981X-RAY DIFFRACTION12.571TORSIONAL
16F5981X-RAY DIFFRACTION12.571TORSIONAL
17G5981X-RAY DIFFRACTION12.571TORSIONAL
18H5981X-RAY DIFFRACTION12.571TORSIONAL
21I523X-RAY DIFFRACTION12.571TORSIONAL
22J523X-RAY DIFFRACTION12.571TORSIONAL
23K523X-RAY DIFFRACTION12.571TORSIONAL
24L523X-RAY DIFFRACTION12.571TORSIONAL
25M523X-RAY DIFFRACTION12.571TORSIONAL
26O523X-RAY DIFFRACTION12.571TORSIONAL
27P523X-RAY DIFFRACTION12.571TORSIONAL
31Q327X-RAY DIFFRACTION12.571TORSIONAL
32R327X-RAY DIFFRACTION12.571TORSIONAL
33T327X-RAY DIFFRACTION12.571TORSIONAL
34U327X-RAY DIFFRACTION12.571TORSIONAL
35V327X-RAY DIFFRACTION12.571TORSIONAL
36W327X-RAY DIFFRACTION12.571TORSIONAL
37X327X-RAY DIFFRACTION12.571TORSIONAL
38Y327X-RAY DIFFRACTION12.571TORSIONAL
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0 / Total num. of bins used: 30

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
2.71-2.740.47282140.42463453366786
2.74-2.770.42521880.38833600378894
2.77-2.810.39992370.3583817405496
2.81-2.840.31072100.32953803401396
2.84-2.880.28562020.28883781398397
2.88-2.920.26852130.26933796400997
2.92-2.960.26691970.25033861405897
2.96-3.010.24012020.24293813401597
3.01-3.050.27641780.24883836401497
3.05-3.10.25472150.24293819403496
3.1-3.160.27182140.2583792400696
3.16-3.210.28921990.27513745394496
3.21-3.270.32642360.29453824406096
3.27-3.340.28181940.30433750394496
3.34-3.410.29921980.263734393295
3.41-3.490.24631870.233765395293
3.49-3.580.22511660.21023462362888
3.58-3.680.24691870.19663756394394
3.68-3.790.19932010.19833851405297
3.79-3.910.18432120.19473773398596
3.91-4.050.2012120.18893878409097
4.05-4.210.19881760.19033855403197
4.21-4.40.18242040.15923794399896
4.4-4.630.1661840.14473805398996
4.63-4.920.1542270.15073662388994
4.92-5.30.16072140.15773487370189
5.3-5.840.20772210.17513750397196
5.84-6.680.2081760.20083772394895
6.68-8.420.23142170.21283724394194
8.42-98.630.21940.19953589378391
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.5623-0.2945-1.322.63630.89882.24710.3772-0.186-0.3421-0.3334-0.0333-0.38720.4475-0.7020.07640.5219-0.0270.14790.4550.07070.495344.764256.859454.4948
22.3878-1.5037-2.81744.2111.6953.519-0.5826-1.076-0.0049-0.4295-0.57470.03180.1480.03150.40070.4188-0.023-0.24960.4439-0.06410.359563.565570.35660.7494
33.76541.90210.41774.48280.62333.36080.043-0.2064-1.08330.00310.037-0.33120.5164-0.2918-0.13710.4246-0.067-0.02760.39930.01850.584550.601252.617252.5708
42.40550.2154-0.44956.9231-1.34652.3108-0.08390.10850.0004-0.66360.44220.1520.1083-0.1169-0.25160.33870.0157-0.04960.3287-0.03940.352758.488668.036245.1429
56.46072.8617-2.98967.35110.52791.8783-0.1786-1.2883-1.27141.06220.04070.70480.9483-0.2560.02380.5836-0.0372-0.10930.37890.16420.61253.899651.776455.4691
63.24860.34310.46540.30310.38990.8122-0.08940.2818-0.06920.32660.09630.06690.106-0.02880.01070.30610.02040.02920.2902-0.00710.309658.399569.73747.4135
72.56093.45681.05794.59411.53920.7487-0.1045-0.04790.4051-0.0395-0.20690.4037-0.10930.00520.03840.3555-0.00710.03810.36720.01830.429653.030971.529352.9125
83.51842.4166-1.46595.1861-2.63795.17130.469-0.61890.61461.0039-0.1553-0.1313-0.31180.3854-0.34580.5358-0.07810.03320.3699-0.06520.605267.677388.059459.6952
97.55042.4038-1.64453.0251-2.48352.34580.7387-0.2059-0.17640.6472-0.5058-0.313-0.2551-0.1602-0.13760.42920.02880.00380.35750.0050.319363.933976.906859.2448
101.57221.85421.9342.79561.63063.70880.2291-0.15480.14390.3673-0.30970.55330.4302-0.34510.25870.43820.01040.03620.4704-0.04560.42443.964962.401148.2635
118.3163-3.18462.91032.4387-0.74432.7015-0.3232-0.56560.477-0.09350.0630.0368-0.3092-0.57750.37960.537-0.09120.04050.4108-0.02050.485929.3603130.211275.22
124.6003-0.1136-0.58352.59410.64583.93230.03410.61820.83040.9937-0.5053-0.11260.06150.3055-0.15220.28930.0168-0.09670.4956-0.0010.383540.787112.48181.6765
134.1307-1.88860.19498.47170.82823.4539-0.1802-1.10111.20040.14630.3977-0.8136-0.5787-0.31670.13320.41110.09310.0240.3986-0.03750.42329.9611126.740979.3589
141.8042-2.9644-0.52034.97910.85920.5536-0.22640.3329-0.8065-0.0629-0.24632.0012-0.6356-1.15190.23540.60550.2408-0.11440.6528-0.17290.703414.375131.741177.2446
152.7509-1.9236-1.40764.73291.65282.5699-0.1309-0.1366-0.4957-0.3864-0.07040.5521-0.1235-0.250.09320.2933-0.0148-0.04790.39750.04030.318927.3214111.852971.679
163.4718-2.05070.54684.8116-0.29932.04650.0648-0.70991.0247-0.2185-0.1671-0.6562-0.8296-0.5090.07590.49690.1515-0.00230.4782-0.09490.485424.3176128.116882.4749
170.7277-0.1712-0.36583.1386-0.6012.50440.114-0.14560.2203-0.16570.0267-0.055-0-0.0866-0.1620.2327-0.0402-0.04330.3375-0.0030.362231.0161111.517571.8886
185.9036-2.5480.4295.7927-0.32670.77690.02190.30770.3701-0.4446-0.0692-0.3788-0.01830.064-0.02020.2969-0.0295-0.01660.39750.03970.318634.4104117.802369.9125
193.29631.02551.09395.72020.54822.516-0.12250.22390.75290.06620.034-1.0245-0.30950.25340.02840.36590.04230.05410.3943-0.05180.693551.4913100.936974.0119
206.5211-4.92550.28947.5706-2.48483.4334-0.6344-0.32170.8520.91690.9165-2.07120.03250.03310.23420.32170.0252-0.07480.3849-0.02760.324743.8262109.022677.6476
211.58390.33721.73862.1896-0.33883.4481-0.06370.30860.5162-0.4071-0.0634-0.1914-0.2171-0.54380.120.3730.02990.04350.43180.00220.400727.2016127.165865.9951
221.9124-0.80151.06492.7382-1.72618.1623-0.00330.6903-0.2725-0.383-0.42270.14440.8820.4151-0.31780.46920.07640.05670.432-0.09680.622985.3839116.247525.5338
233.65781.5594-1.1055.839-0.57423.3482-0.0774-0.73260.5459-0.76260.8311-0.39831.01980.49370.02520.4322-0.0186-0.07980.39180.10340.35882.1987119.270347.8036
242.3721-0.7375-1.75731.8398-0.08744.4334-0.1540.5137-0.2124-0.2059-0.0248-0.0083-0.00480.0490.05160.3503-0.0199-0.11110.4194-0.06020.402180.7809123.07829.237
253.67110.8864-3.52333.2803-0.25993.3876-0.34010.9636-0.6795-0.12650.27690.1467-0.2128-0.4984-0.01420.3936-0.011-0.16470.39870.00960.391372.9438127.664935.6796
261.9761-0.41-2.70022.7344-0.0753.0559-0.0063-0.20210.075-0.517-0.0569-0.7906-0.0351.58160.08610.33960.02150.04680.55760.08230.366989.9415124.141427.9797
271.5965-0.20290.73311.38521.8493.2453-0.0350.1299-0.1523-0.0036-0.0980.2909-0.1668-0.1230.15510.22570.0198-0.02940.24130.00410.359572.2512122.782838.8654
281.36950.0155-1.60841.9169-1.30244.2385-0.06560.089-0.2619-0.15-0.00430.11330.0756-0.1015-0.12520.3430.0147-0.06060.3194-0.0240.463574.713116.271536.1358
296.0321-1.4279-4.47510.60070.16668.4828-0.7309-1.1363-1.42520.55940.17770.71741.28031.1644-0.04770.73150.09340.09610.51280.15240.831472.9667109.933460.6085
309.77-0.8411-1.14357.67512.88692.72990.5383-0.4731-0.66830.5544-0.907-0.0010.5410.46640.69670.3713-0.02730.04250.27740.08630.429666.8789118.110658.9194
312.1507-0.5391-1.31393.1173.56238.69410.018-0.3123-0.3148-0.16680.10980.4228-0.16960.543-0.28840.25620.06410.06160.3790.04690.544676.8298117.078951.0131
321.1321-1.06711.0463.1672-3.36425.6175-0.26880.2547-0.2559-0.9696-0.4117-0.01061.0525-0.5430.14980.4272-0.0065-0.08380.434-0.1560.62776.6647115.895223.9894
336.0795-0.43641.42012.7085-1.56882.0711-1.0169-0.11581.3960.44970.0797-2.0449-0.0717-0.247-0.2213-0.93230.15260.78550.47160.10681.288899.965998.432235.1199
347.40051.7548-2.46426.3968-3.00756.2142-0.863-0.2402-0.2719-1.73550.5335-1.39870.66190.7888-0.29480.6530.06230.05130.4292-0.12420.461883.262484.845930.228
355.73580.2491-1.00130.42750.82691.13760.0228-0.0899-0.18-0.00040.3551-1.4343-0.16710.4013-0.02080.60810.00520.12920.4886-0.03261.1708103.69493.321938.3782
364.23150.4547-0.63363.2320.48262.16220.5831-0.36970.64050.12990.0771-0.63340.07740.3514-0.23110.43580.03150.03860.229-0.00810.667487.389891.60444.7139
375.48551.149-0.79573.6897-0.00031.51050.0292-0.13480.07470.14720.1144-0.6680.28260.2945-0.29460.42810.0363-0.0880.2708-0.02980.571788.337287.54746.7634
386.09732.7980.87222.33281.03440.4917-0.05290.3844-0.4275-0.29430.3926-1.1694-0.02590.5414-0.41350.50840.01410.18260.6259-0.18480.9656103.733290.080435.702
390.9673-0.3371-0.49262.3992-0.1531.5767-0.03430.08550.1420.16530.1948-0.76380.03790.1776-0.21690.35430.0419-0.0250.27580.00890.570984.212389.861143.0207
403.74711.8070.88683.88240.89681.3385-0.22270.15070.0898-0.14160.2459-0.6039-0.3044-0.0002-0.19730.46440.03950.08460.2768-0.00090.510185.632695.704938.9034
417.25151.2528-4.53615.7303-2.79434.4788-0.04440.91970.2179-1.12130.08690.32050.0363-0.6447-0.34660.6470.003-0.0180.47490.07140.491965.172885.31530.8832
422.5389-0.0483-0.22085.5375-0.21452.1404-0.06010.65980.5788-0.83120.42110.44920.03590.033-0.360.46460.04280.09110.34590.05510.462479.651290.892731.3582
434.26651.1680.53442.24531.67821.11490.7575-0.3790.86240.778-0.1603-1.07950.9177-0.06230.05560.5268-0.05780.14430.4212-0.15161.059797.788103.757945.7232
445.9079-3.15051.10165.5551-1.94845.5638-0.5181-1.5229-0.27240.31390.26781.33770.7071-0.22110.13480.80890.03550.28520.450.04810.440140.234761.036778.1954
451.6150.757-0.99886.0849-2.69723.3260.39880.2681-0.34151.5251-0.40381.06990.22510.1805-0.11190.2492-0.0713-0.03330.5668-0.00520.476926.978678.37371.7614
461.9663-0.2820.24545.1057-0.76322.6754-0.1768-0.569-0.39430.37570.0266-0.23930.43860.04680.22350.48030.05890.04540.4530.03140.418640.438772.490181.8465
473.1591-1.3994-0.0553.2210.73342.8311-0.47660.2961-1.07960.1352-0.0114-0.30930.60970.11050.43470.64960.03590.06530.50630.20340.795734.053563.034285.5106
483.05770.2799-0.91112.66970.74230.3722-0.0638-0.1257-0.3067-0.00040.19710.17710.15850.0697-0.1240.34420.0216-0.05030.3192-0.01880.264839.895980.764576.0232
492.0987-0.0172-0.3163.52630.25191.57920.1540.0026-0.2135-0.3696-0.1059-0.19630.69120.12760.00170.3282-0.0051-0.00310.3114-0.04880.271540.655874.83771.7581
508.9114-4.43622.26324.5216-3.28852.7105-1.51220.9842-1.1639-2.53920.43742.1599-0.3522-1.4091-0.1130.7688-0.0466-0.22170.8044-0.02370.416225.749688.748156.5178
510.82210.16080.07792.5062-1.63560.9429-0.00120.3098-0.1698-0.6505-0.0650.09940.0469-0.3972-0.03210.3868-0.0711-0.00750.3709-0.03010.296531.480984.022865.4363
524.7752-1.68694.78472.3231-2.53865.7187-0.3989-0.83330.06930.19920.3315-1.0940.61050.3151-0.04950.6270.1686-0.05660.5721-0.0040.675850.721564.93878.764
533.40111.3582-2.39032.8768-0.49855.2230.8013-1.65941.06960.52-1.3799-1.0453-1.2889-0.43650.4560.2547-0.07780.68230.5935-0.54260.901548.8605143.089380.2985
541.21881.5528-1.2141.6531-1.34951.02360.44640.06461.15750.20910.249-0.20780.1102-0.5641-0.05810.48710.0302-0.00180.33880.09370.621352.3841141.849457.785
552.9323-0.07461.02972.23891.3152.37580.0298-0.5520.37540.6317-0.38060.2017-0.3485-0.39860.25960.5909-0.06720.18070.4198-0.05630.623756.5815140.716176.3348
561.78870.61760.18024.56682.46563.8937-0.2475-0.49190.15791.20180.11060.51470.00660.84460.24650.4223-0.05340.06910.39350.01460.482863.1993134.640869.5728
570.9451-0.5424-0.81370.45630.90118.1110.4366-0.35780.97390.8763-0.69820.6374-1.6303-0.27060.19891.0671-0.10610.26320.6221-0.24380.884455.1986149.858577.8321
581.629-0.0852-0.03392.5026-0.46071.62950.0003-0.2285-0.0460.28340.02860.1474-0.1892-0.0233-0.13090.313-0.03090.12970.36920.01520.535758.6713132.884467.17
591.5960.0265-0.39981.5469-0.35185.10110.09240.05120.22410.0969-0.23470.328-0.48880.33230.11770.3058-0.00030.09230.35930.05880.561451.013133.079467.5529
603.57640.0311-3.22614.42150.39134.3718-0.06780.5625-0.0478-0.4074-0.13820.2611-0.2443-0.50370.15860.31140.0102-0.0040.40720.01670.644749.7159132.384251.5592
613.71081.68883.11873.61193.56746.49-0.286-0.72180.69981.1081-0.5730.57970.09680.25210.66540.7537-0.15650.21460.6967-0.02710.630952.7597133.383284.8454
625.9459-0.6438-0.26161.97290.13051.4803-0.2044-0.79650.78-0.47680.37390.05790.0834-0.68540.40680.5625-0.06580.00490.45260.22660.521727.676359.7655-4.6833
634.7532-0.5657-1.87170.4701-0.70452.61680.10670.70520.73870.1672-0.3925-0.25560.22650.336-0.25770.49590.0108-0.02950.46780.02690.433744.383446.29375.8219
642.8956-1.2976-0.46114.23441.21031.9033-0.0332-0.58330.1772-0.40090.12040.6214-0.3064-0.45170.13710.4836-0.1281-0.02320.46280.120.347624.10257.32121.1391
654.7909-3.7702-2.04764.33651.73472.1945-0.3213-0.0796-0.6515-0.19770.21040.16530.44750.02420.10020.5112-0.0642-0.07570.42750.10080.339731.954942.3523-4.1778
664.9479-3.75-1.86085.47251.25724.25530.5182-0.0358-0.3241-1.0323-0.23850.225-0.3553-0.43060.17380.4344-0.0703-0.06830.36870.05940.406430.385638.867-1.6378
678.0933-1.2621-0.23062.6439-2.68932.40930.7603-0.55682.08510.8957-0.04240.3527-1.09140.1240.04440.52510.00810.04760.48620.01370.398625.324757.24055.2048
68-0.1236-0.1441-0.2131.8779-0.7431.9845-0.02960.1167-0.0646-0.23220.0275-0.05750.4833-0.17160.03260.5018-0.03850.03960.4486-0.00390.366835.237540.7328-2.7866
695.0662-2.56981.64542.1222-1.21970.8336-0.38140.57-0.551-0.14040.0761-0.01920.05870.1556-0.0510.5462-0.04430.01790.4748-0.00290.44137.04547.2246-6.1798
707.5362-2.266-2.68577.24625.3285.8241-0.1799-1.0603-0.11560.2639-0.3335-2.4746-0.5330.348-0.27150.72990.00520.22310.7860.0651.091160.417838.70180.2633
711.7472-1.67740.19426.6003-0.48730.5579-0.0217-0.11090.3232-0.45020.0097-0.8118-0.10890.1567-0.14340.55920.02460.13390.4528-0.01710.595550.672137.15051.4181
725.56550.59961.20881.344-0.02411.5109-0.41720.92370.6104-0.53480.2983-0.1744-0.07710.25640.00060.5687-0.110.00150.48820.03420.369327.710554.0665-10.462
739.76271.21251.03082.99450.43992.7946-0.07980.6154-0.2707-0.40330.46610.26660.8114-0.359-0.8560.7768-0.12650.0840.47420.12730.488733.996363.4015-12.803
741.6528-3.6937-2.38699.31214.88594.78250.6522-0.1740.1038-1.1475-0.0299-1.66760.0936-0.60620.2630.3238-0.0491-0.27270.56570.0810.294250.280176.2187-3.471
756.62624.37562.7164.30863.61014.87870.0080.6186-1.31290.240.433-0.56920.98920.12350.21710.6628-0.06390.02010.5210.15570.525840.275666.116-13.2932
761.59820.57530.2293.75120.38572.13470.030.17520.21590.11290.00490.450.269-0.14220.06520.3927-0.04280.04080.37640.09820.36237.025876.8723-12.7727
771.70950.4629-0.80292.62570.62081.64640.0624-0.52780.09520.4675-0.08850.2754-0.0536-0.56140.0040.5027-0.03360.00540.43560.12810.400536.173775.4519-3.8302
783.19621.0661-0.5042.79391.9521.91550.3674-0.6493-0.57941.49380.0545-0.62060.02540.0697-0.00830.9325-0.1241-0.14730.58790.11530.538451.674286.92711.1673
795.01364.68141.23436.40631.91481.33720.50630.0014-0.28950.9629-0.1396-0.10190.1123-0.1359-0.2650.6213-0.08430.06240.55280.02740.442545.432776.14641.715
804.0471-1.02073.15343.1249-0.31716.13550.4037-0.4747-1.1843-0.0360.72580.9585-0.391-1.52970.43240.4319-0.0946-0.01730.68750.17580.811924.462669.1644-12.6758
817.10571.7642-0.22222.6191-1.30398.1401-0.19920.22791.75-0.42980.45131.0161-0.6864-1.32830.0160.49640.1119-0.06610.58620.10170.854948.176178.971145.8138
825.8526-2.0259-0.34543.00470.62664.44060.44141.16970.1259-0.9332-0.2697-1.0333-0.1088-0.251-0.18930.50190.04460.12340.41360.0520.421535.6283114.130959.0607
835.42271.7512-3.33562.4832-0.28962.6191-0.78730.105-1.22370.0987-0.33760.68591.1712-1.25090.85510.5817-0.22190.1110.5915-0.07590.853663.8554112.265335.2432
845.1868-1.9559-0.03013.7864-1.04763.93560.1324-0.04790.4395-0.1633-0.0916-0.20220.2155-0.2526-0.24260.3354-0.01710.13470.2628-0.00750.588678.147102.170644.015
855.99930.8457-1.31124.4033-0.49057.39890.0060.30050.5-0.4325-0.0442-0.1764-0.61710.05660.01560.38840.04110.01920.3103-0.01510.357948.850879.313765.5136
863.3544-1.66191.22741.7841-1.06341.01290.00850.07130.38460.0336-0.27410.16320.47270.05330.17050.3989-0.00430.07370.3664-0.01130.430249.3054122.470567.8113
876.9559-0.2127-1.36084.88711.86115.52320.14051.69180.0001-1.2343-0.0012-1.00750.03650.5078-0.83021.27650.09470.04660.77140.1410.559839.547341.8872-16.1988
882.7264-0.4116-1.30494.01151.40073.5158-0.5067-0.5181-1.9650.60540.14450.1560.5180.58581.18890.9087-0.19870.28990.8007-0.04950.989528.934880.26133.3929
899.24474.1419-6.87586.6491-3.20136.5889-1.0436-2.4931-0.5319-0.9369-0.8543-0.30140.89682.53490.64920.38670.1094-0.1060.5673-0.08070.88660.850651.706451.8716
903.40933.76881.90568.96420.14922.80390.961-1.4278-0.11521.8414-1.3998-0.18891.0202-0.4449-0.3840.65550.3760.01050.5442-0.01030.426621.725122.383885.8656
912.3742-2.6432-2.864.27542.12464.54620.2136-0.99362.50670.1020.5501-1.3126-0.7520.5539-0.33650.6473-0.1147-0.10310.6375-0.05210.333387.9519131.229531.2783
924.45794.9779-5.47578.6839-5.04896.9466-0.6018-0.62930.6647-1.11520.199-0.73891.2434-0.556-0.03670.36730.0213-0.09130.5621-0.15470.8868102.401583.119139.9171
938.07050.2746-0.64614.2507-0.33998.62160.4637-0.5832-0.22410.4223-0.7572-0.0581-0.0613-0.22790.14590.53630.12680.0120.69980.14010.453132.89968.923590.3906
945.9933-0.215-3.4363.84983.51516.47710.81740.94741.95960.3187-0.3901-0.6083-0.4362-0.51680.21670.7572-0.18810.03940.5911-0.10540.514162.4088149.783774.6286
953.0795-3.19370.17879.1001-4.57356.42150.35860.02060.77853.1154-0.87410.3480.03481.14870.24750.42880.0741-0.02490.7020.08750.551124.111550.75359.1952
962.3494-1.26410.34763.48130.17635.64930.83970.26210.2075-1.4029-0.9648-1.11620.7360.84870.47710.4821-0.1069-0.06390.65210.04450.46843.03972.2429-22.9679
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'A' and (resid 1 through 11 )A1 - 11
2X-RAY DIFFRACTION2chain 'A' and (resid 12 through 21 )A12 - 21
3X-RAY DIFFRACTION3chain 'A' and (resid 22 through 38 )A22 - 38
4X-RAY DIFFRACTION4chain 'A' and (resid 39 through 61 )A39 - 61
5X-RAY DIFFRACTION5chain 'A' and (resid 62 through 76 )A62 - 76
6X-RAY DIFFRACTION6chain 'A' and (resid 77 through 104 )A77 - 104
7X-RAY DIFFRACTION7chain 'A' and (resid 105 through 117 )A105 - 117
8X-RAY DIFFRACTION8chain 'A' and (resid 118 through 131 )A118 - 131
9X-RAY DIFFRACTION9chain 'A' and (resid 132 through 139 )A132 - 139
10X-RAY DIFFRACTION10chain 'A' and (resid 140 through 154 )A140 - 154
11X-RAY DIFFRACTION11chain 'B' and (resid 2 through 12 )B2 - 12
12X-RAY DIFFRACTION12chain 'B' and (resid 13 through 21 )B13 - 21
13X-RAY DIFFRACTION13chain 'B' and (resid 22 through 30 )B22 - 30
14X-RAY DIFFRACTION14chain 'B' and (resid 31 through 38 )B31 - 38
15X-RAY DIFFRACTION15chain 'B' and (resid 39 through 61 )B39 - 61
16X-RAY DIFFRACTION16chain 'B' and (resid 62 through 76 )B62 - 76
17X-RAY DIFFRACTION17chain 'B' and (resid 77 through 103 )B77 - 103
18X-RAY DIFFRACTION18chain 'B' and (resid 104 through 117 )B104 - 117
19X-RAY DIFFRACTION19chain 'B' and (resid 118 through 131 )B118 - 131
20X-RAY DIFFRACTION20chain 'B' and (resid 132 through 139 )B132 - 139
21X-RAY DIFFRACTION21chain 'B' and (resid 140 through 154 )B140 - 154
22X-RAY DIFFRACTION22chain 'C' and (resid 2 through 11 )C2 - 11
23X-RAY DIFFRACTION23chain 'C' and (resid 12 through 21 )C12 - 21
24X-RAY DIFFRACTION24chain 'C' and (resid 22 through 50 )C22 - 50
25X-RAY DIFFRACTION25chain 'C' and (resid 51 through 62 )C51 - 62
26X-RAY DIFFRACTION26chain 'C' and (resid 63 through 76 )C63 - 76
27X-RAY DIFFRACTION27chain 'C' and (resid 77 through 103 )C77 - 103
28X-RAY DIFFRACTION28chain 'C' and (resid 104 through 117 )C104 - 117
29X-RAY DIFFRACTION29chain 'C' and (resid 118 through 124 )C118 - 124
30X-RAY DIFFRACTION30chain 'C' and (resid 125 through 131 )C125 - 131
31X-RAY DIFFRACTION31chain 'C' and (resid 132 through 139 )C132 - 139
32X-RAY DIFFRACTION32chain 'C' and (resid 140 through 154 )C140 - 154
33X-RAY DIFFRACTION33chain 'D' and (resid 3 through 11 )D3 - 11
34X-RAY DIFFRACTION34chain 'D' and (resid 12 through 21 )D12 - 21
35X-RAY DIFFRACTION35chain 'D' and (resid 22 through 37 )D22 - 37
36X-RAY DIFFRACTION36chain 'D' and (resid 38 through 50 )D38 - 50
37X-RAY DIFFRACTION37chain 'D' and (resid 51 through 62 )D51 - 62
38X-RAY DIFFRACTION38chain 'D' and (resid 63 through 76 )D63 - 76
39X-RAY DIFFRACTION39chain 'D' and (resid 77 through 103 )D77 - 103
40X-RAY DIFFRACTION40chain 'D' and (resid 104 through 117 )D104 - 117
41X-RAY DIFFRACTION41chain 'D' and (resid 118 through 131 )D118 - 131
42X-RAY DIFFRACTION42chain 'D' and (resid 132 through 144 )D132 - 144
43X-RAY DIFFRACTION43chain 'D' and (resid 145 through 153 )D145 - 153
44X-RAY DIFFRACTION44chain 'E' and (resid 2 through 11 )E2 - 11
45X-RAY DIFFRACTION45chain 'E' and (resid 12 through 21 )E12 - 21
46X-RAY DIFFRACTION46chain 'E' and (resid 22 through 62 )E22 - 62
47X-RAY DIFFRACTION47chain 'E' and (resid 63 through 76 )E63 - 76
48X-RAY DIFFRACTION48chain 'E' and (resid 77 through 103 )E77 - 103
49X-RAY DIFFRACTION49chain 'E' and (resid 104 through 117 )E104 - 117
50X-RAY DIFFRACTION50chain 'E' and (resid 118 through 124 )E118 - 124
51X-RAY DIFFRACTION51chain 'E' and (resid 125 through 144 )E125 - 144
52X-RAY DIFFRACTION52chain 'E' and (resid 145 through 153 )E145 - 153
53X-RAY DIFFRACTION53chain 'F' and (resid 2 through 11 )F2 - 11
54X-RAY DIFFRACTION54chain 'F' and (resid 12 through 21 )F12 - 21
55X-RAY DIFFRACTION55chain 'F' and (resid 22 through 50 )F22 - 50
56X-RAY DIFFRACTION56chain 'F' and (resid 51 through 62 )F51 - 62
57X-RAY DIFFRACTION57chain 'F' and (resid 63 through 76 )F63 - 76
58X-RAY DIFFRACTION58chain 'F' and (resid 77 through 104 )F77 - 104
59X-RAY DIFFRACTION59chain 'F' and (resid 105 through 117 )F105 - 117
60X-RAY DIFFRACTION60chain 'F' and (resid 118 through 144 )F118 - 144
61X-RAY DIFFRACTION61chain 'F' and (resid 145 through 153 )F145 - 153
62X-RAY DIFFRACTION62chain 'G' and (resid 1 through 11 )G1 - 11
63X-RAY DIFFRACTION63chain 'G' and (resid 12 through 21 )G12 - 21
64X-RAY DIFFRACTION64chain 'G' and (resid 22 through 37 )G22 - 37
65X-RAY DIFFRACTION65chain 'G' and (resid 38 through 50 )G38 - 50
66X-RAY DIFFRACTION66chain 'G' and (resid 51 through 61 )G51 - 61
67X-RAY DIFFRACTION67chain 'G' and (resid 62 through 76 )G62 - 76
68X-RAY DIFFRACTION68chain 'G' and (resid 77 through 103 )G77 - 103
69X-RAY DIFFRACTION69chain 'G' and (resid 104 through 117 )G104 - 117
70X-RAY DIFFRACTION70chain 'G' and (resid 118 through 124 )G118 - 124
71X-RAY DIFFRACTION71chain 'G' and (resid 125 through 139 )G125 - 139
72X-RAY DIFFRACTION72chain 'G' and (resid 140 through 154 )G140 - 154
73X-RAY DIFFRACTION73chain 'H' and (resid 2 through 11 )H2 - 11
74X-RAY DIFFRACTION74chain 'H' and (resid 12 through 21 )H12 - 21
75X-RAY DIFFRACTION75chain 'H' and (resid 22 through 30 )H22 - 30
76X-RAY DIFFRACTION76chain 'H' and (resid 31 through 103 )H31 - 103
77X-RAY DIFFRACTION77chain 'H' and (resid 104 through 117 )H104 - 117
78X-RAY DIFFRACTION78chain 'H' and (resid 118 through 131 )H118 - 131
79X-RAY DIFFRACTION79chain 'H' and (resid 132 through 144 )H132 - 144
80X-RAY DIFFRACTION80chain 'H' and (resid 145 through 153 )H145 - 153
81X-RAY DIFFRACTION81chain 'I' and (resid 9 through 23 )I9 - 23
82X-RAY DIFFRACTION82chain 'J' and (resid 9 through 23 )J9 - 23
83X-RAY DIFFRACTION83chain 'K' and (resid 9 through 23 )K9 - 23
84X-RAY DIFFRACTION84chain 'L' and (resid 8 through 23 )L8 - 23
85X-RAY DIFFRACTION85chain 'M' and (resid 8 through 23 )M8 - 23
86X-RAY DIFFRACTION86chain 'N' and (resid 6 through 23 )N6 - 23
87X-RAY DIFFRACTION87chain 'O' and (resid 9 through 22 )O9 - 22
88X-RAY DIFFRACTION88chain 'P' and (resid 9 through 22 )P9 - 22
89X-RAY DIFFRACTION89chain 'Q' and (resid 11 through 17 )Q11 - 17
90X-RAY DIFFRACTION90chain 'R' and (resid 11 through 18 )R11 - 18
91X-RAY DIFFRACTION91chain 'T' and (resid 11 through 17 )T11 - 17
92X-RAY DIFFRACTION92chain 'U' and (resid 11 through 17 )U11 - 17
93X-RAY DIFFRACTION93chain 'V' and (resid 11 through 17 )V11 - 17
94X-RAY DIFFRACTION94chain 'W' and (resid 11 through 17 )W11 - 17
95X-RAY DIFFRACTION95chain 'X' and (resid 11 through 17 )X11 - 17
96X-RAY DIFFRACTION96chain 'Y' and (resid 11 through 17 )Y11 - 17

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