+Open data
-Basic information
Entry | Database: PDB / ID: 7kja | ||||||
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Title | Crystal structure of the EphA2 intracellular KD-SAM domains | ||||||
Components | Ephrin type-A receptor 2 | ||||||
Keywords | TRANSFERASE / Eph receptor / kinase / SAM / allostery | ||||||
Function / homology | Function and homology information notochord cell development / notochord formation / lens fiber cell morphogenesis / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / negative regulation of lymphangiogenesis / axial mesoderm formation / pericyte cell differentiation / cAMP metabolic process / positive regulation of bicellular tight junction assembly / regulation of blood vessel endothelial cell migration ...notochord cell development / notochord formation / lens fiber cell morphogenesis / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / negative regulation of lymphangiogenesis / axial mesoderm formation / pericyte cell differentiation / cAMP metabolic process / positive regulation of bicellular tight junction assembly / regulation of blood vessel endothelial cell migration / ephrin receptor activity / leading edge membrane / negative regulation of chemokine production / post-anal tail morphogenesis / bone remodeling / response to growth factor / tight junction / activation of GTPase activity / regulation of lamellipodium assembly / branching involved in mammary gland duct morphogenesis / EPH-Ephrin signaling / neural tube development / RND1 GTPase cycle / RND2 GTPase cycle / RND3 GTPase cycle / mammary gland epithelial cell proliferation / RHOV GTPase cycle / EPHA-mediated growth cone collapse / growth factor binding / regulation of cell adhesion mediated by integrin / lamellipodium membrane / RHOU GTPase cycle / RHOG GTPase cycle / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / RAC2 GTPase cycle / RAC3 GTPase cycle / vasculogenesis / transmembrane receptor protein tyrosine kinase activity / regulation of angiogenesis / regulation of ERK1 and ERK2 cascade / negative regulation of angiogenesis / keratinocyte differentiation / RAC1 GTPase cycle / positive regulation of protein localization to plasma membrane / osteoclast differentiation / cell chemotaxis / skeletal system development / molecular function activator activity / protein localization to plasma membrane / cell motility / receptor protein-tyrosine kinase / ruffle membrane / neuron differentiation / osteoblast differentiation / intrinsic apoptotic signaling pathway in response to DNA damage / virus receptor activity / cell migration / lamellipodium / receptor complex / cell adhesion / positive regulation of cell migration / defense response to Gram-positive bacterium / cadherin binding / inflammatory response / focal adhesion / cell surface / ATP binding / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 1.75 Å | ||||||
Authors | Lechtenberg, B.C. / Pasquale, E.B. | ||||||
Funding support | United States, 1items
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Citation | Journal: Nat Commun / Year: 2021 Title: Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker. Authors: Lechtenberg, B.C. / Gehring, M.P. / Light, T.P. / Horne, C.R. / Matsumoto, M.W. / Hristova, K. / Pasquale, E.B. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7kja.cif.gz | 538.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7kja.ent.gz | 368.5 KB | Display | PDB format |
PDBx/mmJSON format | 7kja.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7kja_validation.pdf.gz | 1 MB | Display | wwPDB validaton report |
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Full document | 7kja_full_validation.pdf.gz | 1022.6 KB | Display | |
Data in XML | 7kja_validation.xml.gz | 33.2 KB | Display | |
Data in CIF | 7kja_validation.cif.gz | 49.5 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/kj/7kja ftp://data.pdbj.org/pub/pdb/validation_reports/kj/7kja | HTTPS FTP |
-Related structure data
Related structure data | 7kjbC 7kjcC 3kkaS 4pdoS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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