Entry | Database: PDB / ID: 7jxt |
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Title | Ovine COX-1 in complex with the subtype-selective derivative 2a |
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Components | Prostaglandin G/H synthase 1 |
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Keywords | OXIDOREDUCTASE/INHIBITOR / Cyclooxygenase-1 / oxidoreductase inhibitor / OXIDOREDUCTASE / OXIDOREDUCTASE-INHIBITOR complex |
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Function / homology | Function and homology information
prostaglandin-endoperoxide synthase / prostaglandin-endoperoxide synthase activity / oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen / cyclooxygenase pathway / prostaglandin biosynthetic process / regulation of blood pressure / peroxidase activity / response to oxidative stress / neuron projection / intracellular membrane-bounded organelle ...prostaglandin-endoperoxide synthase / prostaglandin-endoperoxide synthase activity / oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen / cyclooxygenase pathway / prostaglandin biosynthetic process / regulation of blood pressure / peroxidase activity / response to oxidative stress / neuron projection / intracellular membrane-bounded organelle / heme binding / endoplasmic reticulum membrane / protein homodimerization activity / metal ion binding / cytoplasmSimilarity search - Function Haem peroxidase, animal-type / Haem peroxidase domain superfamily, animal type / Animal haem peroxidase / Animal heme peroxidase superfamily profile. / Haem peroxidase superfamily / EGF-like domain profile. / EGF-like domainSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Ovis aries (sheep) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.35 Å |
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Authors | Ko, Y. / Iaselli, M. / Miciaccia, M. / Friedrich, L. / Schneider, G. / Scilimati, A. / Cingolani, G. |
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Funding support | United States, 3items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | OD017987 | United States | National Institutes of Health/National Cancer Institute (NIH/NCI) | CA56036 | United States | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | OD023479 | United States |
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Citation | Journal: Adv Sci / Year: 2021 Title: Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design. Authors: Friedrich, L. / Cingolani, G. / Ko, Y.H. / Iaselli, M. / Miciaccia, M. / Perrone, M.G. / Neukirch, K. / Bobinger, V. / Merk, D. / Hofstetter, R.K. / Werz, O. / Koeberle, A. / Scilimati, A. / Schneider, G. |
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History | Deposition | Aug 27, 2020 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Sep 1, 2021 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 16, 2022 | Group: Database references / Structure summary / Category: citation / citation_author / struct Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _struct.title |
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Revision 1.2 | Oct 18, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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