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- PDB-3olt: X-ray crystal structure of arachidonic acid bound to the cyclooxy... -

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Basic information

Entry
Database: PDB / ID: 3olt
TitleX-ray crystal structure of arachidonic acid bound to the cyclooxygenase channel of R513H murine COX-2
ComponentsProstaglandin G/H synthase 2
KeywordsOXIDOREDUCTASE / Monotopic Membrane Protein / N-glycosylation / Membrane
Function / homology
Function and homology information


Biosynthesis of DHA-derived SPMs / Biosynthesis of EPA-derived SPMs / Biosynthesis of DPAn-3 SPMs / Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives / Synthesis of 15-eicosatetraenoic acid derivatives / cellular response to non-ionic osmotic stress / : / Synthesis of Prostaglandins (PG) and Thromboxanes (TX) / prostaglandin-endoperoxide synthase / prostaglandin-endoperoxide synthase activity ...Biosynthesis of DHA-derived SPMs / Biosynthesis of EPA-derived SPMs / Biosynthesis of DPAn-3 SPMs / Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives / Synthesis of 15-eicosatetraenoic acid derivatives / cellular response to non-ionic osmotic stress / : / Synthesis of Prostaglandins (PG) and Thromboxanes (TX) / prostaglandin-endoperoxide synthase / prostaglandin-endoperoxide synthase activity / cyclooxygenase pathway / negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress / positive regulation of prostaglandin biosynthetic process / regulation of neuroinflammatory response / response to selenium ion / positive regulation of fever generation / prostaglandin secretion / cellular response to fluid shear stress / response to nematode / nuclear inner membrane / prostaglandin biosynthetic process / dioxygenase activity / bone mineralization / nuclear outer membrane / decidualization / brown fat cell differentiation / keratinocyte differentiation / positive regulation of brown fat cell differentiation / embryo implantation / peroxidase activity / regulation of blood pressure / regulation of cell population proliferation / cellular response to hypoxia / response to oxidative stress / neuron projection / heme binding / endoplasmic reticulum membrane / negative regulation of apoptotic process / enzyme binding / protein homodimerization activity / metal ion binding / cytosol / cytoplasm
Similarity search - Function
: / Myeloperoxidase, subunit C / Haem peroxidase domain superfamily, animal type / Haem peroxidase, animal-type / Haem peroxidase domain superfamily, animal type / Animal haem peroxidase / Animal heme peroxidase superfamily profile. / Laminin / Laminin / EGF-like domain ...: / Myeloperoxidase, subunit C / Haem peroxidase domain superfamily, animal type / Haem peroxidase, animal-type / Haem peroxidase domain superfamily, animal type / Animal haem peroxidase / Animal heme peroxidase superfamily profile. / Laminin / Laminin / EGF-like domain / Haem peroxidase superfamily / EGF-like domain profile. / EGF-like domain / Ribbon / Orthogonal Bundle / Mainly Beta / Mainly Alpha
Similarity search - Domain/homology
ARACHIDONIC ACID / PROTOPORPHYRIN IX CONTAINING CO / Prostaglandin G/H synthase 2
Similarity search - Component
Biological speciesMus musculus (house mouse)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.45 Å
AuthorsVecchio, A.J. / Malkowski, M.G.
CitationJournal: J.Biol.Chem. / Year: 2011
Title: The structural basis of endocannabinoid oxygenation by cyclooxygenase-2.
Authors: Vecchio, A.J. / Malkowski, M.G.
History
DepositionAug 26, 2010Deposition site: RCSB / Processing site: RCSB
Revision 1.0Apr 13, 2011Provider: repository / Type: Initial release
Revision 1.1Jul 13, 2011Group: Version format compliance
Revision 1.2Nov 8, 2017Group: Refinement description / Category: software / Item: _software.classification / _software.name
Revision 2.0Jul 29, 2020Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Database references / Derived calculations / Structure summary
Category: atom_site / chem_comp ...atom_site / chem_comp / database_PDB_caveat / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / pdbx_validate_chiral / pdbx_validate_close_contact / struct_asym / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen
Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_validate_chiral.auth_asym_id / _pdbx_validate_chiral.auth_seq_id / _pdbx_validate_close_contact.auth_asym_id_2 / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details
Description: Carbohydrate remediation / Provider: repository / Type: Remediation
Revision 2.1Sep 6, 2023Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary
Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 3.0Dec 25, 2024Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Structure summary
Category: atom_site / chem_comp_atom ...atom_site / chem_comp_atom / chem_comp_bond / pdbx_entry_details / pdbx_modification_feature / pdbx_nonpoly_scheme / pdbx_struct_conn_angle / pdbx_validate_chiral / pdbx_validate_close_contact / struct_conn
Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _chem_comp_atom.pdbx_aromatic_flag / _chem_comp_atom.pdbx_stereo_config / _chem_comp_bond.pdbx_aromatic_flag / _pdbx_nonpoly_scheme.asym_id / _pdbx_nonpoly_scheme.auth_seq_num / _pdbx_nonpoly_scheme.ndb_seq_num / _pdbx_nonpoly_scheme.pdb_seq_num / _pdbx_nonpoly_scheme.pdb_strand_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Prostaglandin G/H synthase 2
B: Prostaglandin G/H synthase 2
hetero molecules


Theoretical massNumber of molelcules
Total (without water)141,53127
Polymers136,0572
Non-polymers5,47425
Water9,242513
1


  • Idetical with deposited unit
  • defined by author&software
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area16040 Å2
ΔGint30 kcal/mol
Surface area42050 Å2
MethodPISA
Unit cell
Length a, b, c (Å)121.148, 132.048, 180.758
Angle α, β, γ (deg.)90.00, 90.00, 90.00
Int Tables number23
Space group name H-MI222

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Components

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Protein , 1 types, 2 molecules AB

#1: Protein Prostaglandin G/H synthase 2 / Cyclooxygenase-2 / COX-2 / Prostaglandin-endoperoxide synthase 2 / Prostaglandin H2 synthase 2 / ...Cyclooxygenase-2 / COX-2 / Prostaglandin-endoperoxide synthase 2 / Prostaglandin H2 synthase 2 / PGH synthase 2 / PGHS-2 / PHS II / Glucocorticoid-regulated inflammatory cyclooxygenase / Gripghs / TIS10 protein / Macrophage activation-associated marker protein P71/73 / PES-2


Mass: 68028.438 Da / Num. of mol.: 2 / Mutation: R513H
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mus musculus (house mouse) / Gene: Ptgs2, Cox-2, Cox2, Pghs-b, Tis10 / Plasmid: pFastbac1 / Production host: Spodoptera frugiperda (fall armyworm) / Strain (production host): SF21
References: UniProt: Q05769, prostaglandin-endoperoxide synthase

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Sugars , 4 types, 7 molecules

#2: Polysaccharide 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 424.401 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
DGlcpNAcb1-4DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/1,2,1/[a2122h-1b_1-5_2*NCC/3=O]/1-1/a4-b1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-L-IdopNAc]{[(4+1)][b-D-GlcpNAc]{}}}LINUCSPDB-CARE
#3: Polysaccharide alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta- ...alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose


Type: oligosaccharide / Mass: 586.542 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
DescriptorTypeProgram
DManpa1-4DGlcpNAcb1-4DGlcpNAcb1-Glycam Condensed SequenceGMML 1.0
WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1a_1-5]/1-1-2/a4-b1_b4-c1WURCSPDB2Glycan 1.1.0
[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][a-D-Manp]{}}}}LINUCSPDB-CARE
#7: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0
#8: Sugar ChemComp-BOG / octyl beta-D-glucopyranoside / Beta-Octylglucoside / octyl beta-D-glucoside / octyl D-glucoside / octyl glucoside


Type: D-saccharide / Mass: 292.369 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Formula: C14H28O6 / Comment: detergent*YM
IdentifierTypeProgram
b-octylglucosideIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0

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Non-polymers , 4 types, 531 molecules

#4: Chemical
ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL


Mass: 62.068 Da / Num. of mol.: 14 / Source method: obtained synthetically / Formula: C2H6O2
#5: Chemical ChemComp-ACD / ARACHIDONIC ACID


Mass: 304.467 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C20H32O2
#6: Chemical ChemComp-COH / PROTOPORPHYRIN IX CONTAINING CO


Mass: 619.575 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C34H32CoN4O4
#9: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 513 / Source method: isolated from a natural source / Formula: H2O

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Details

Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.66 Å3/Da / Density % sol: 53.7 %
Crystal growTemperature: 296 K / Method: vapor diffusion, sitting drop / pH: 7.5
Details: 23-34% polyacrylic acid 5100, 100mM HEPES pH 7.5, 20mM MgCl2, VAPOR DIFFUSION, SITTING DROP, temperature 296K

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: CHESS / Beamline: A1 / Wavelength: 0.978 Å
DetectorType: ADSC QUANTUM 210 / Detector: CCD / Date: Apr 30, 2009
RadiationMonochromator: Si (111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.978 Å / Relative weight: 1
ReflectionResolution: 2.45→20 Å / Num. all: 53369 / Num. obs: 53369 / % possible obs: 99.8 % / Observed criterion σ(F): -3 / Observed criterion σ(I): -6 / Redundancy: 4.9 % / Biso Wilson estimate: 43.5 Å2 / Rmerge(I) obs: 0.099 / Net I/σ(I): 11.8
Reflection shellResolution: 2.45→2.58 Å / Redundancy: 4.9 % / Rmerge(I) obs: 0.536 / Mean I/σ(I) obs: 2.7 / Num. unique all: 7699 / % possible all: 100

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Processing

Software
NameVersionClassification
Adxvdata processing
PHASERphasing
REFMAC5.5.0088refinement
MOSFLMdata reduction
SCALAdata scaling
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB entry 1CVU

1cvu


Resolution: 2.45→19.86 Å / Cor.coef. Fo:Fc: 0.958 / Cor.coef. Fo:Fc free: 0.925 / SU B: 14.647 / SU ML: 0.156 / Cross valid method: THROUGHOUT / σ(F): -6 / ESU R Free: 0.24 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
RfactorNum. reflection% reflectionSelection details
Rfree0.21929 2707 5.1 %RANDOM
Rwork0.16281 ---
obs0.16565 50659 100 %-
all-53369 --
Solvent computationIon probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: MASK
Displacement parametersBiso mean: 30.636 Å2
Baniso -1Baniso -2Baniso -3
1-0.81 Å20 Å20 Å2
2--0.26 Å20 Å2
3----1.07 Å2
Refine analyzeLuzzati sigma a obs: 0.306 Å
Refinement stepCycle: LAST / Resolution: 2.45→19.86 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms8865 0 368 513 9746
Refine LS restraints
Refine-IDTypeDev idealDev ideal targetNumber
X-RAY DIFFRACTIONr_bond_refined_d0.0130.0229576
X-RAY DIFFRACTIONr_angle_refined_deg1.6632.00413012
X-RAY DIFFRACTIONr_dihedral_angle_1_deg5.51151118
X-RAY DIFFRACTIONr_dihedral_angle_2_deg36.54923.978445
X-RAY DIFFRACTIONr_dihedral_angle_3_deg15.352151499
X-RAY DIFFRACTIONr_dihedral_angle_4_deg14.241544
X-RAY DIFFRACTIONr_chiral_restr0.0950.21382
X-RAY DIFFRACTIONr_gen_planes_refined0.0060.0217343
X-RAY DIFFRACTIONr_mcbond_it0.4831.55537
X-RAY DIFFRACTIONr_mcangle_it0.95729000
X-RAY DIFFRACTIONr_scbond_it1.90734039
X-RAY DIFFRACTIONr_scangle_it3.1274.54000
LS refinement shellResolution: 2.45→2.513 Å / Total num. of bins used: 20
RfactorNum. reflection% reflection
Rfree0.293 210 -
Rwork0.225 3619 -
obs-37347 100 %
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.2913-0.0510.29582.7403-0.58121.8461-0.0132-0.0751-0.02610.23990.14270.0341-0.2947-0.5393-0.12950.10250.03520.05220.26820.02520.24621.258737.910560.2305
26.9124-3.34136.410211.5213-3.62546.0640.5237-0.3755-1.129-0.2950.48090.44270.6631-0.4985-1.00460.3969-0.16530.10030.43570.11540.5777-3.924518.891463.888
35.0169-2.8468-2.16258.9631-1.64949.9967-0.2444-0.0304-0.1167-0.0558-0.08740.550.3576-0.48220.33180.0821-0.1030.00960.20610.00480.413613.28593.343366.8844
41.3529-0.3741-0.33080.8612-0.24034.0944-0.0437-0.16080.1290.1490.0890.0623-0.225-0.2135-0.04530.04670.02270.02130.036-0.01390.078718.594136.346267.2177
51.3323-1.20230.17181.4608-0.47631.222-0.0854-0.14080.12170.10660.0464-0.108-0.1929-0.00760.0390.048-0.007-0.01680.0794-0.00710.06733.059923.143966.3626
63.29510.22191.721.5221-0.58584.97120.03760.06050.0858-0.07480.0108-0.1318-0.04220.4379-0.04840.0134-0.00360.04010.06940.0110.141751.218518.991955.9593
72.0212-0.2748-0.24331.2909-0.09172.19440.0381-0.22810.14940.0028-0.0129-0.18120.04960.3853-0.02520.02250.01230.00580.09770.01020.092144.813816.081858.4174
80.536-0.43020.06081.6784-0.63032.6071-0.0429-0.1737-0.19320.07230.11820.21040.1877-0.056-0.07530.04150.0030.03680.08430.04620.102325.512615.444866.2926
95.88581.56420.39916.70662.63724.31210.0009-0.38920.15020.3451-0.0071-0.1314-0.00520.54940.00620.13420.0559-0.04760.3003-0.00380.053747.134516.481878.5556
101.642-0.93270.95321.5984-0.83541.7467-0.1076-0.21840.03370.14970.12450.0378-0.0646-0.0508-0.01690.08330.03650.05130.1225-0.01310.045320.233929.778975.963
111.4487-0.8787-0.96531.15651.33252.722-0.1213-0.2889-0.140.03550.07160.20760.0115-0.10660.04970.12150.02240.01540.10940.05520.12318.869621.869571.1426
120.9434-1.5262-0.29494.10730.47455.9903-0.1062-0.1087-0.36770.07460.06280.20310.7448-0.29890.04340.1754-0.02890.02870.0430.07460.246837.62563.371364.8703
134.83620.7354-1.95940.6528-0.21923.83110.15660.066-0.3241-0.2392-0.0873-0.09750.69760.2175-0.06930.43980.0571-0.01970.079-0.0320.294933.67241.706533.4817
1411.9578-6.7073.23527.6578-2.83621.88780.53170.256-0.587-0.5938-0.03631.57380.6295-0.4542-0.49540.6245-0.1952-0.08510.3813-0.03540.606214.926-0.284328.5472
157.4868-3.8662-1.96235.36390.58549.9721-0.05240.3009-0.4402-0.1659-0.11260.32350.5124-0.68840.1650.2484-0.1946-0.03270.1827-0.0640.43170.946218.731226.3953
162.9367-2.9609-0.79873.3141-0.33024.18930.03040.0584-0.2607-0.1256-0.04980.28680.3724-0.01320.01940.07780.02310.00160.02190.00410.047131.835918.833939.9618
171.0143-0.98490.06531.6843-0.11372.40840.1180.16530.0502-0.2099-0.0879-0.14990.15580.286-0.03010.07370.02520.02850.08290.02230.085230.347927.133222.0448
181.5355-0.48160.6485.2101-0.75084.15240.00040.08910.32340.2768-0.0811-0.3093-0.37890.28750.08070.0491-0.01940.00530.03740.04170.127522.054150.97138.691
192.49742.03910.36084.31730.58352.1401-0.17720.53120.1202-0.47730.1819-0.5344-0.38380.4595-0.00470.2596-0.10920.09350.30860.070.404227.899749.973127.5707
201.1604-0.3211-0.51822.14270.53153.4447-0.00440.08550.0592-0.0398-0.05870.271-0.2247-0.31450.06310.01680.0244-0.00210.06970.04480.107110.07542.115638.4256
213.3835-0.23110.61632.0268-0.54683.4761-0.01040.0305-0.1291-0.08040.0210.27650.2303-0.2372-0.01060.0609-0.0099-0.04150.0193-0.01150.081814.965124.476433.6285
221.4512-0.5187-0.42767.25831.95372.34290.23050.37780.2449-0.563-0.0395-0.0997-0.38070.0371-0.19110.17940.06920.02070.20490.09060.083819.519446.245814.2542
231.4396-0.39170.09591.5542-0.71352.42030.11080.2482-0.1695-0.3256-0.09230.11010.4354-0.0348-0.01850.25480.0682-0.02020.1333-0.04320.083426.819819.025316.6053
241.5083-0.36340.2411.6596-1.40483.42040.05970.1046-0.0402-0.00010.17280.30290.0372-0.3617-0.23250.0117-0.00710.00510.06320.03540.1086.660538.323735.9926
Refinement TLS group
IDRefine-IDRefine TLS-IDAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1A33 - 68
2X-RAY DIFFRACTION2A69 - 86
3X-RAY DIFFRACTION3A87 - 122
4X-RAY DIFFRACTION4A123 - 187
5X-RAY DIFFRACTION5A188 - 235
6X-RAY DIFFRACTION6A236 - 268
7X-RAY DIFFRACTION7A269 - 346
8X-RAY DIFFRACTION8A347 - 400
9X-RAY DIFFRACTION9A401 - 429
10X-RAY DIFFRACTION10A430 - 478
11X-RAY DIFFRACTION11A479 - 553
12X-RAY DIFFRACTION12A554 - 584
13X-RAY DIFFRACTION13B33 - 67
14X-RAY DIFFRACTION14B68 - 87
15X-RAY DIFFRACTION15B88 - 122
16X-RAY DIFFRACTION16B123 - 148
17X-RAY DIFFRACTION17B149 - 227
18X-RAY DIFFRACTION18B228 - 271
19X-RAY DIFFRACTION19B272 - 304
20X-RAY DIFFRACTION20B305 - 356
21X-RAY DIFFRACTION21B357 - 389
22X-RAY DIFFRACTION22B390 - 438
23X-RAY DIFFRACTION23B439 - 534
24X-RAY DIFFRACTION24B535 - 583

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