登録情報 | データベース: PDB / ID: 7e7e |
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タイトル | The co-crystal structure of ACE2 with Fab |
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要素 | - (h11B11-Fab) x 2
- Processed angiotensin-converting enzyme 2
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キーワード | ANTIVIRAL PROTEIN / ACE2 Fab |
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機能・相同性 | 機能・相同性情報
positive regulation of amino acid transport / angiotensin-converting enzyme 2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / regulation of systemic arterial blood pressure by renin-angiotensin / tryptophan transport / positive regulation of gap junction assembly / regulation of vasoconstriction / regulation of cardiac conduction ...positive regulation of amino acid transport / angiotensin-converting enzyme 2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / regulation of systemic arterial blood pressure by renin-angiotensin / tryptophan transport / positive regulation of gap junction assembly / regulation of vasoconstriction / regulation of cardiac conduction / peptidyl-dipeptidase activity / maternal process involved in female pregnancy / angiotensin maturation / Metabolism of Angiotensinogen to Angiotensins / metallocarboxypeptidase activity / carboxypeptidase activity / negative regulation of signaling receptor activity / Attachment and Entry / positive regulation of cardiac muscle contraction / regulation of cytokine production / viral life cycle / blood vessel diameter maintenance / brush border membrane / regulation of transmembrane transporter activity / negative regulation of smooth muscle cell proliferation / negative regulation of ERK1 and ERK2 cascade / cilium / metallopeptidase activity / endocytic vesicle membrane / positive regulation of reactive oxygen species metabolic process / virus receptor activity / regulation of cell population proliferation / regulation of inflammatory response / endopeptidase activity / Induction of Cell-Cell Fusion / Potential therapeutics for SARS / entry receptor-mediated virion attachment to host cell / receptor-mediated endocytosis of virus by host cell / membrane fusion / Attachment and Entry / receptor-mediated virion attachment to host cell / symbiont entry into host cell / membrane raft / apical plasma membrane / endoplasmic reticulum lumen / cell surface / extracellular space / zinc ion binding / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Collectrin-like domain profile. / Collectrin domain / Renal amino acid transporter / Peptidase family M2 domain profile. / Peptidase M2, peptidyl-dipeptidase A / Angiotensin-converting enzyme / Neutral zinc metallopeptidases, zinc-binding region signature.類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.8 Å |
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データ登録者 | Xiao, J.Y. / Zhang, Y. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Science Foundation (NSF, China) | | 中国 |
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引用 | ジャーナル: Nat Commun / 年: 2021 タイトル: A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants. 著者: Du, Y. / Shi, R. / Zhang, Y. / Duan, X. / Li, L. / Zhang, J. / Wang, F. / Zhang, R. / Shen, H. / Wang, Y. / Wu, Z. / Peng, Q. / Pan, T. / Sun, W. / Huang, W. / Feng, Y. / Feng, H. / Xiao, J. ...著者: Du, Y. / Shi, R. / Zhang, Y. / Duan, X. / Li, L. / Zhang, J. / Wang, F. / Zhang, R. / Shen, H. / Wang, Y. / Wu, Z. / Peng, Q. / Pan, T. / Sun, W. / Huang, W. / Feng, Y. / Feng, H. / Xiao, J. / Tan, W. / Wang, Y. / Wang, C. / Yan, J. |
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履歴 | 登録 | 2021年2月26日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年7月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年1月26日 | Group: Database references / カテゴリ: citation / citation_author / database_2 Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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