登録情報 | データベース: PDB / ID: 7e0p |
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タイトル | Crystal Structure of Human Indoleamine 2,3-dioxygenagse 1 (hIDO1) Complexed with 4-(((6-Bromo-1H-indazol-4-yl)amino)methyl)phenol (2) |
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要素 | Indoleamine 2,3-dioxygenase 1 |
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キーワード | OXIDOREDUCTASE / Indoleamine 2 / 3-dioxygenase 1 |
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機能・相同性 | 機能・相同性情報
indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response ... indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response / 'de novo' NAD biosynthetic process from tryptophan / tryptophan catabolic process / Tryptophan catabolism / negative regulation of T cell apoptotic process / positive regulation of T cell apoptotic process / swimming behavior / negative regulation of interleukin-10 production / multicellular organismal response to stress / negative regulation of T cell proliferation / T cell proliferation / positive regulation of interleukin-12 production / female pregnancy / response to lipopolysaccharide / electron transfer activity / inflammatory response / heme binding / metal ion binding / cytosol / cytoplasm類似検索 - 分子機能 Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase signature 1. / Indoleamine 2,3-dioxygenase signature 2. / Tryptophan/Indoleamine 2,3-dioxygenase-like類似検索 - ドメイン・相同性 ACETIC ACID / PROTOPORPHYRIN IX CONTAINING FE / Chem-HU0 / Indoleamine 2,3-dioxygenase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.635 Å |
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データ登録者 | Li, G.-B. / Ning, X.-L. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 81874291;81502989; 82073698 | 中国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2021 タイトル: X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease. 著者: Ning, X.L. / Li, Y.Z. / Huo, C. / Deng, J. / Gao, C. / Zhu, K.R. / Wang, M. / Wu, Y.X. / Yu, J.L. / Ren, Y.L. / Luo, Z.Y. / Li, G. / Chen, Y. / Wang, S.Y. / Peng, C. / Yang, L.L. / Wang, Z.Y. ...著者: Ning, X.L. / Li, Y.Z. / Huo, C. / Deng, J. / Gao, C. / Zhu, K.R. / Wang, M. / Wu, Y.X. / Yu, J.L. / Ren, Y.L. / Luo, Z.Y. / Li, G. / Chen, Y. / Wang, S.Y. / Peng, C. / Yang, L.L. / Wang, Z.Y. / Wu, Y. / Qian, S. / Li, G.B. |
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履歴 | 登録 | 2021年1月28日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年7月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月29日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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