登録情報 | データベース: PDB / ID: 7ds6 |
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タイトル | Crystal structure of actin capping protein in complex with twinflin-1/CD2AP CPI chimera peptide (TWN-CDC) |
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要素 | - F-actin-capping protein subunit alpha-1
- F-actin-capping protein subunit beta isoforms 1
- Twinfilin-1,CD2-associated protein
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キーワード | CYTOSOLIC PROTEIN / actin dynamics / actin capping protein / twinfilin / CARMIL / V-1 |
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機能・相同性 | 機能・相同性情報
regulation of actin phosphorylation / Advanced glycosylation endproduct receptor signaling / RHOD GTPase cycle / RHOF GTPase cycle / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / COPI-independent Golgi-to-ER retrograde traffic / response to glial cell derived neurotrophic factor / RHOBTB2 GTPase cycle / COPI-mediated anterograde transport / negative regulation of small GTPase mediated signal transduction ...regulation of actin phosphorylation / Advanced glycosylation endproduct receptor signaling / RHOD GTPase cycle / RHOF GTPase cycle / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / COPI-independent Golgi-to-ER retrograde traffic / response to glial cell derived neurotrophic factor / RHOBTB2 GTPase cycle / COPI-mediated anterograde transport / negative regulation of small GTPase mediated signal transduction / Factors involved in megakaryocyte development and platelet production / transforming growth factor beta1 production / localization of cell / Rab protein signal transduction / WASH complex / : / F-actin capping protein complex / negative regulation of transforming growth factor beta1 production / slit diaphragm / negative regulation of filopodium assembly / response to transforming growth factor beta / podocyte differentiation / immunological synapse formation / endothelium development / sequestering of actin monomers / nerve growth factor signaling pathway / cell-cell adhesion mediated by cadherin / collateral sprouting / protein heterooligomerization / negative regulation of actin filament polymerization / renal albumin absorption / substrate-dependent cell migration, cell extension / membrane organization / cell junction assembly / phosphatidylinositol 3-kinase regulatory subunit binding / actin filament depolymerization / cell-cell junction organization / filopodium assembly / barbed-end actin filament capping / actin polymerization or depolymerization / regulation of cell morphogenesis / podosome / regulation of lamellipodium assembly / Nephrin family interactions / lamellipodium assembly / clathrin binding / maintenance of blood-brain barrier / myofibril / cortical cytoskeleton / nuclear envelope lumen / positive regulation of cardiac muscle hypertrophy / cell leading edge / glucose import / filamentous actin / brush border / neurotrophin TRK receptor signaling pathway / centriolar satellite / actin monomer binding / protein secretion / lymph node development / adipose tissue development / stress-activated MAPK cascade / ruffle / cytoskeleton organization / phosphatidylinositol-4,5-bisphosphate binding / ERK1 and ERK2 cascade / actin filament polymerization / hippocampal mossy fiber to CA3 synapse / phosphatidylinositol 3-kinase/protein kinase B signal transduction / trans-Golgi network membrane / liver development / filopodium / positive regulation of protein secretion / actin filament / regulation of actin cytoskeleton organization / actin filament organization / synapse organization / Schaffer collateral - CA1 synapse / response to virus / protein catabolic process / response to insulin / regulation of synaptic plasticity / neuromuscular junction / cell morphogenesis / lipid metabolic process / structural constituent of cytoskeleton / fibrillar center / positive regulation of neuron projection development / Z disc / response to wounding / SH3 domain binding / positive regulation of protein localization to nucleus / male gonad development / cell-cell junction / actin filament binding / cell migration / actin cytoskeleton / late endosome / lamellipodium / T cell receptor signaling pathway類似検索 - 分子機能 Twinfilin / CD2-associated protein, first SH3 domain / CD2-associated protein, second SH3 domain / CD2-associated protein, third SH3 domain / F-actin-capping protein subunit beta / F-actin capping protein, beta subunit, conserved site / F-actin-capping protein subunit beta, N-terminal domain / F-actin capping protein, beta subunit / F-actin capping protein beta subunit signature. / F-actin capping protein, alpha subunit, conserved site ...Twinfilin / CD2-associated protein, first SH3 domain / CD2-associated protein, second SH3 domain / CD2-associated protein, third SH3 domain / F-actin-capping protein subunit beta / F-actin capping protein, beta subunit, conserved site / F-actin-capping protein subunit beta, N-terminal domain / F-actin capping protein, beta subunit / F-actin capping protein beta subunit signature. / F-actin capping protein, alpha subunit, conserved site / F-actin capping protein alpha subunit signature 1. / F-actin capping protein alpha subunit signature 2. / F-actin-capping protein subunit alpha / F-actin-capping protein subunit alpha/beta / F-actin-capping protein subunit alpha/beta, domain 2 / F-actin capping protein, alpha subunit, domain 1 / F-actin capping protein alpha subunit / Actin-depolymerising factor homology domain / Cofilin/tropomyosin-type actin-binding protein / ADF-H domain profile. / Actin depolymerisation factor/cofilin -like domains / ADF-H/Gelsolin-like domain superfamily / Variant SH3 domain / SH3 domain / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain類似検索 - ドメイン・相同性 F-actin-capping protein subunit alpha-1 / F-actin-capping protein subunit beta isoforms 1 and 2 / Twinfilin-1 / CD2-associated protein類似検索 - 構成要素 |
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生物種 | ![](img/tx_bird.gif) Gallus gallus (ニワトリ)
![](img/tx_mammal.gif) Mus musculus (ハツカネズミ)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.69 Å |
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データ登録者 | Takeda, S. |
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資金援助 | 日本, 3件 組織 | 認可番号 | 国 |
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Japan Society for the Promotion of Science (JSPS) | 16K17708 | 日本 | Japan Society for the Promotion of Science (JSPS) | 17K07373 | 日本 | Japan Society for the Promotion of Science (JSPS) | 20K06522 | 日本 |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2021 タイトル: Structural Insights into the Regulation of Actin Capping Protein by Twinfilin C-terminal Tail. 著者: Takeda, S. / Koike, R. / Fujiwara, I. / Narita, A. / Miyata, M. / Ota, M. / Maeda, Y. |
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履歴 | 登録 | 2020年12月30日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年3月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年3月17日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.page_first / _citation.page_last ..._citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID |
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改定 1.2 | 2021年4月7日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume / _citation.title |
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改定 1.3 | 2023年11月29日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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