+Open data
-Basic information
Entry | Database: PDB / ID: 6p1l | ||||||
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Title | Crystal structure of EGFR in complex with EAI045 | ||||||
Components | Epidermal growth factor receptor | ||||||
Keywords | TRANSFERASE/TRANSFERASE Inhibitor / egfr / allosteric inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex | ||||||
Function / homology | Function and homology information Complex I biogenesis / Respiratory electron transport / : / mitochondrial electron transport, NADH to ubiquinone / proton motive force-driven mitochondrial ATP synthesis / NADH dehydrogenase (ubiquinone) activity / aerobic respiration / electron transfer activity / mitochondrial inner membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.8 Å | ||||||
Authors | Heppner, D.E. / Eck, M.J. | ||||||
Funding support | United States, 1items
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Citation | Journal: Acs Med.Chem.Lett. / Year: 2019 Title: Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. Authors: De Clercq, D.J.H. / Heppner, D.E. / To, C. / Jang, J. / Park, E. / Yun, C.H. / Mushajiang, M. / Shin, B.H. / Gero, T.W. / Scott, D.A. / Janne, P.A. / Eck, M.J. / Gray, N.S. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6p1l.cif.gz | 249.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6p1l.ent.gz | 197.8 KB | Display | PDB format |
PDBx/mmJSON format | 6p1l.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6p1l_validation.pdf.gz | 688.3 KB | Display | wwPDB validaton report |
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Full document | 6p1l_full_validation.pdf.gz | 700.3 KB | Display | |
Data in XML | 6p1l_validation.xml.gz | 3.4 KB | Display | |
Data in CIF | 6p1l_validation.cif.gz | 14.5 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/p1/6p1l ftp://data.pdbj.org/pub/pdb/validation_reports/p1/6p1l | HTTPS FTP |
-Related structure data
Related structure data | 6p1dC 6p8qC 5d41S S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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