登録情報 | データベース: PDB / ID: 7drv |
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タイトル | Structural basis of SARS-CoV-2-closely-related bat coronavirus RaTG13 to hACE2 |
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要素 | - Angiotensin-converting enzyme 2
アンジオテンシン変換酵素2 - Spike glycoprotein
スパイクタンパク質 |
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キーワード | HYDROLASE/VIRAL PROTEIN / RaTG13 (RaTG13) / RBD / SARS-CoV-2 (SARSコロナウイルス2) / ACE2 (アンジオテンシン変換酵素2) / VIRAL PROTEIN (ウイルスタンパク質) / HYDROLASE-VIRAL PROTEIN complex |
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機能・相同性 | 機能・相同性情報
positive regulation of amino acid transport / アンジオテンシン変換酵素2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / regulation of systemic arterial blood pressure by renin-angiotensin / tryptophan transport / positive regulation of gap junction assembly / regulation of vasoconstriction / regulation of cardiac conduction ...positive regulation of amino acid transport / アンジオテンシン変換酵素2 / positive regulation of L-proline import across plasma membrane / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; 金属プロテアーゼ / angiotensin-mediated drinking behavior / regulation of systemic arterial blood pressure by renin-angiotensin / tryptophan transport / positive regulation of gap junction assembly / regulation of vasoconstriction / regulation of cardiac conduction / peptidyl-dipeptidase activity / maternal process involved in female pregnancy / angiotensin maturation / metallocarboxypeptidase activity / Metabolism of Angiotensinogen to Angiotensins / Attachment and Entry / carboxypeptidase activity / negative regulation of signaling receptor activity / positive regulation of cardiac muscle contraction / regulation of cytokine production / ウイルスのライフサイクル / blood vessel diameter maintenance / brush border membrane / regulation of transmembrane transporter activity / negative regulation of smooth muscle cell proliferation / endocytosis involved in viral entry into host cell / negative regulation of ERK1 and ERK2 cascade / 繊毛 / metallopeptidase activity / endocytic vesicle membrane / positive regulation of reactive oxygen species metabolic process / virus receptor activity / regulation of cell population proliferation / regulation of inflammatory response / endopeptidase activity / Induction of Cell-Cell Fusion / Potential therapeutics for SARS / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / entry receptor-mediated virion attachment to host cell / receptor-mediated endocytosis of virus by host cell / Attachment and Entry / membrane fusion / receptor-mediated virion attachment to host cell / symbiont entry into host cell / 脂質ラフト / apical plasma membrane / fusion of virus membrane with host plasma membrane / 小胞体 / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) / host cell plasma membrane / virion membrane / 細胞膜 / extracellular space / extracellular exosome / zinc ion binding / extracellular region / 生体膜 / identical protein binding / 細胞膜類似検索 - 分子機能 Collectrin-like domain profile. / Collectrin domain / Renal amino acid transporter / Peptidase family M2 domain profile. / Peptidase M2, peptidyl-dipeptidase A / アンジオテンシン変換酵素 / Neutral zinc metallopeptidases, zinc-binding region signature. / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily ...Collectrin-like domain profile. / Collectrin domain / Renal amino acid transporter / Peptidase family M2 domain profile. / Peptidase M2, peptidyl-dipeptidase A / アンジオテンシン変換酵素 / Neutral zinc metallopeptidases, zinc-binding region signature. / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト)
![](img/tx_virus.gif) Bat coronavirus RaTG13 (RaTG13) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.09 Å |
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データ登録者 | Liu, K.F. / Pan, X.Q. / Li, L.J. / Feng, Y. / Meng, Y.M. / Zhang, Y.F. / Wu, L.L. / Chen, Q. / Zheng, A.Q. / Song, C.L. ...Liu, K.F. / Pan, X.Q. / Li, L.J. / Feng, Y. / Meng, Y.M. / Zhang, Y.F. / Wu, L.L. / Chen, Q. / Zheng, A.Q. / Song, C.L. / Jia, Y.F. / Niu, S. / Qiao, C.P. / Zhao, X. / Ma, D.L. / Ma, X.P. / Tan, S.G. / Qi, J.X. / Gao, G.F. / Wang, Q.H. |
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引用 | ジャーナル: Cell / 年: 2021 タイトル: Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species. 著者: Liu, K. / Pan, X. / Li, L. / Yu, F. / Zheng, A. / Du, P. / Han, P. / Meng, Y. / Zhang, Y. / Wu, L. / Chen, Q. / Song, C. / Jia, Y. / Niu, S. / Lu, D. / Qiao, C. / Chen, Z. / Ma, D. / Ma, X. / ...著者: Liu, K. / Pan, X. / Li, L. / Yu, F. / Zheng, A. / Du, P. / Han, P. / Meng, Y. / Zhang, Y. / Wu, L. / Chen, Q. / Song, C. / Jia, Y. / Niu, S. / Lu, D. / Qiao, C. / Chen, Z. / Ma, D. / Ma, X. / Tan, S. / Zhao, X. / Qi, J. / Gao, G.F. / Wang, Q. |
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履歴 | 登録 | 2020年12月29日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年8月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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