登録情報 | データベース: PDB / ID: 7dp8 |
---|
タイトル | Crystal structure of T2R-TTL-Cevipabulin-eribulin complex |
---|
要素 | - Stathmin-4
- Tubulin alpha-1B chain
- Tubulin beta chain
- Tubulin tyrosine ligase
|
---|
キーワード | STRUCTURAL PROTEIN / tubulin inhibitor / tublin |
---|
機能・相同性 | 機能・相同性情報
tubulin-tyrosine ligase activity / Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane / Hedgehog 'off' state / Cilium Assembly / Intraflagellar transport / COPI-dependent Golgi-to-ER retrograde traffic / Carboxyterminal post-translational modifications of tubulin / RHOH GTPase cycle / Sealing of the nuclear envelope (NE) by ESCRT-III / Kinesins ...tubulin-tyrosine ligase activity / Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane / Hedgehog 'off' state / Cilium Assembly / Intraflagellar transport / COPI-dependent Golgi-to-ER retrograde traffic / Carboxyterminal post-translational modifications of tubulin / RHOH GTPase cycle / Sealing of the nuclear envelope (NE) by ESCRT-III / Kinesins / PKR-mediated signaling / The role of GTSE1 in G2/M progression after G2 checkpoint / Aggrephagy / Resolution of Sister Chromatid Cohesion / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / Separation of Sister Chromatids / RHO GTPases activate IQGAPs / RHO GTPases Activate Formins / Recruitment of NuMA to mitotic centrosomes / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / MHC class II antigen presentation / microtubule depolymerization / COPI-mediated anterograde transport / regulation of microtubule polymerization or depolymerization / tubulin binding / spindle microtubule / 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与 / protein modification process / structural constituent of cytoskeleton / microtubule cytoskeleton organization / microtubule cytoskeleton / neuron projection development / mitotic cell cycle / growth cone / microtubule / neuron projection / nucleotide binding / GTPase activity / GTP binding / Golgi apparatus / metal ion binding / cytoplasm類似検索 - 分子機能 Tubulin-tyrosine ligase/Tubulin polyglutamylase / Tubulin-tyrosine ligase family / TTL domain profile. / Stathmin family / Stathmin, conserved site / Stathmin superfamily / Stathmin family / Stathmin family signature 1. / Stathmin family signature 2. / Stathmin-like (SLD) domain profile. ...Tubulin-tyrosine ligase/Tubulin polyglutamylase / Tubulin-tyrosine ligase family / TTL domain profile. / Stathmin family / Stathmin, conserved site / Stathmin superfamily / Stathmin family / Stathmin family signature 1. / Stathmin family signature 2. / Stathmin-like (SLD) domain profile. / Alpha tubulin / Tubulin-beta mRNA autoregulation signal. / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tubulin/FtsZ, C-terminal / Tubulin/FtsZ, 2-layer sandwich domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ, GTPase domain / Tubulin/FtsZ, GTPase domain superfamily類似検索 - ドメイン・相同性 Chem-6K9 / PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / Chem-G2X / GUANOSINE-5'-DIPHOSPHATE / GUANOSINE-5'-TRIPHOSPHATE / Tubulin beta chain / Tubulin tyrosine ligase / Stathmin-4 / Tubulin alpha-1B chain類似検索 - 構成要素 |
---|
生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ)
![](img/tx_bird.gif) Gallus gallus (ニワトリ)
![](img/tx_mammal.gif) Sus scrofa (ブタ) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.446 Å |
---|
データ登録者 | Chen, L.J. / Chen, Q. / Yu, Y. / Yang, J.H. |
---|
引用 | ジャーナル: Sci Adv / 年: 2021 タイトル: Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect. 著者: Yang, J. / Yu, Y. / Li, Y. / Yan, W. / Ye, H. / Niu, L. / Tang, M. / Wang, Z. / Yang, Z. / Pei, H. / Wei, H. / Zhao, M. / Wen, J. / Yang, L. / Ouyang, L. / Wei, Y. / Chen, Q. / Li, W. / Chen, L. |
---|
履歴 | 登録 | 2020年12月18日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2021年7月7日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年11月29日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|