登録情報 | データベース: PDB / ID: 7ddx |
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タイトル | Crystal structure of KANK1 S1179F mutant in complex wtih eIF4A1 |
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要素 | - Eukaryotic initiation factor 4A-I
- KN motif and ankyrin repeat domains 1
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キーワード | PROTEIN BINDING / nephrotic syndrome / kidney ankyrin repeat-containing protein / eukaryotic initiation factor / complex |
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機能・相同性 | 機能・相同性情報
negative regulation of lamellipodium morphogenesis / negative regulation of ruffle assembly / Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / Deadenylation of mRNA / Translation initiation complex formation / Ribosomal scanning and start codon recognition / ISG15 antiviral mechanism / podocyte cell migration / L13a-mediated translational silencing of Ceruloplasmin expression / GTP hydrolysis and joining of the 60S ribosomal subunit ...negative regulation of lamellipodium morphogenesis / negative regulation of ruffle assembly / Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / Deadenylation of mRNA / Translation initiation complex formation / Ribosomal scanning and start codon recognition / ISG15 antiviral mechanism / podocyte cell migration / L13a-mediated translational silencing of Ceruloplasmin expression / GTP hydrolysis and joining of the 60S ribosomal subunit / negative regulation of substrate adhesion-dependent cell spreading / eukaryotic translation initiation factor 4F complex / negative regulation of actin filament polymerization / cytoplasmic translational initiation / regulation of establishment of cell polarity / negative regulation of Rho protein signal transduction / positive regulation of wound healing / negative regulation of insulin receptor signaling pathway / translation initiation factor activity / negative regulation of cell migration / translational initiation / ruffle membrane / beta-catenin binding / positive regulation of canonical Wnt signaling pathway / double-stranded RNA binding / negative regulation of neuron projection development / actin cytoskeleton organization / cell population proliferation / RNA helicase activity / cytoskeleton / RNA helicase / ATP hydrolysis activity / ATP binding / cytoplasm類似検索 - 分子機能 : / Kank N-terminal motif / KN motif / ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain / DEAD-box subfamily ATP-dependent helicases signature. / ATP-dependent RNA helicase DEAD-box, conserved site / RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain ...: / Kank N-terminal motif / KN motif / ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain / DEAD-box subfamily ATP-dependent helicases signature. / ATP-dependent RNA helicase DEAD-box, conserved site / RNA helicase, DEAD-box type, Q motif / DEAD-box RNA helicase Q motif profile. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Helicase conserved C-terminal domain / Ankyrin repeat-containing domain superfamily / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 KN motif and ankyrin repeat domains 1 / Eukaryotic initiation factor 4A-I類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | Pan, W. / Xu, Y. / Wei, Z. |
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資金援助 | 中国, 2件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 31770791 | 中国 | National Natural Science Foundation of China (NSFC) | 31971131 | 中国 |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2021 タイトル: Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A. 著者: Xu, Y. / Guo, C. / Pan, W. / Zhao, C. / Ding, Y. / Xie, X. / Wei, Z. / Sun, Y. / Yu, C. |
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履歴 | 登録 | 2020年10月30日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年9月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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