Entry Database : PDB / ID : 7cqp Structure visualization Downloads & linksTitle Complex of TRPC4 and Calmodulin_Nlobe ComponentsCalmodulin-1 Peptide from Short transient receptor potential channel 4 DetailsKeywords SIGNALING PROTEIN / Calmodulin / TRP channelFunction / homology Function and homology informationFunction Domain/homology Component
regulation of action potential firing rate / Activation of RAC1 downstream of NMDARs / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / CaMK IV-mediated phosphorylation of CREB / Glycogen breakdown (glycogenolysis) / Sodium/Calcium exchangers / CLEC7A (Dectin-1) induces NFAT activation / Reduction of cytosolic Ca++ levels / Activation of Ca-permeable Kainate Receptor ... regulation of action potential firing rate / Activation of RAC1 downstream of NMDARs / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / CaMK IV-mediated phosphorylation of CREB / Glycogen breakdown (glycogenolysis) / Sodium/Calcium exchangers / CLEC7A (Dectin-1) induces NFAT activation / Reduction of cytosolic Ca++ levels / Activation of Ca-permeable Kainate Receptor / Calcineurin activates NFAT / Synthesis of IP3 and IP4 in the cytosol / RHO GTPases activate PAKs / gamma-aminobutyric acid secretion / Calmodulin induced events / Inactivation, recovery and regulation of the phototransduction cascade / Ion transport by P-type ATPases / eNOS activation / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / Phase 0 - rapid depolarisation / Unblocking of NMDA receptors, glutamate binding and activation / Protein methylation / RAF activation / Ca2+ pathway / RAS processing / negative regulation of calcium ion import across plasma membrane / VEGFR2 mediated vascular permeability / protein serine/threonine phosphatase complex / Smooth Muscle Contraction / Extra-nuclear estrogen signaling / RHO GTPases activate IQGAPs / manganese ion transport / RAF/MAP kinase cascade / positive regulation of voltage-gated calcium channel activity / store-operated calcium channel activity / calcineurin complex / PKA activation / negative regulation of voltage-gated calcium channel activity / TRP channels / Platelet degranulation / Stimuli-sensing channels / positive regulation of calcium ion import across plasma membrane / cation channel complex / regulation of response to tumor cell / DAPK1-calmodulin complex / positive regulation of autophagic cell death / inositol 1,4,5 trisphosphate binding / Ion homeostasis / FCERI mediated Ca+2 mobilization / positive regulation of calcineurin-NFAT signaling cascade / establishment of protein localization to mitochondrial membrane / calcium ion import / type 3 metabotropic glutamate receptor binding / oligodendrocyte differentiation / regulation of synaptic vesicle endocytosis / organelle localization by membrane tethering / cortical cytoskeleton / response to corticosterone / autophagosome membrane docking / mitochondrion-endoplasmic reticulum membrane tethering / regulation of cardiac muscle cell action potential / negative regulation of high voltage-gated calcium channel activity / N-terminal myristoylation domain binding / positive regulation of ryanodine-sensitive calcium-release channel activity / protein phosphatase activator activity / adenylate cyclase binding / sperm midpiece / positive regulation of cyclic-nucleotide phosphodiesterase activity / nitric-oxide synthase binding / detection of calcium ion / catalytic complex / negative regulation of ryanodine-sensitive calcium-release channel activity / regulation of calcium ion transport / regulation of cardiac muscle contraction / calcium channel inhibitor activity / positive regulation of phosphoprotein phosphatase activity / activation of adenylate cyclase activity / potassium ion transmembrane transport / adenylate cyclase activator activity / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / phosphatidylinositol 3-kinase binding / titin binding / positive regulation of protein dephosphorylation / voltage-gated potassium channel complex / sarcomere / calcium channel complex / regulation of ryanodine-sensitive calcium-release channel activity / response to amphetamine / regulation of heart rate / regulation of cytosolic calcium ion concentration / mitochondrial membrane / enzyme regulator activity / nitric-oxide synthase regulator activity / calcium ion transmembrane transport / calcium-mediated signaling / regulation of cytokinesis / regulation of synaptic vesicle exocytosis / calcium channel activity / synaptic vesicle membrane / caveola Similarity search - Function Transient receptor potential channel, canonical 4 / Transient receptor ion channel II / Transient receptor ion channel domain / Transient receptor potential channel, canonical / EF-hand domain pair / Ankyrin repeat region circular profile. / Ankyrin repeat profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily ... Transient receptor potential channel, canonical 4 / Transient receptor ion channel II / Transient receptor ion channel domain / Transient receptor potential channel, canonical / EF-hand domain pair / Ankyrin repeat region circular profile. / Ankyrin repeat profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Ion transport protein / Ion transport domain / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.9 Å DetailsAuthors Shen, Z.S. Funding support China, 2items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) 31670765 China National Natural Science Foundation of China (NSFC) 31870746 China
CitationJournal : Structure / Year : 2021Title : Calmodulin binds to Drosophila TRP with an unexpected mode.Authors : Chen, W. / Shen, Z. / Asteriti, S. / Chen, Z. / Ye, F. / Sun, Z. / Wan, J. / Montell, C. / Hardie, R.C. / Liu, W. / Zhang, M. History Deposition Aug 11, 2020 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jun 23, 2021 Provider : repository / Type : Initial release