登録情報 | データベース: PDB / ID: 7cqp |
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タイトル | Complex of TRPC4 and Calmodulin_Nlobe |
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要素 | - Calmodulin-1
カルモジュリン - Peptide from Short transient receptor potential channel 4
ペプチド |
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キーワード | SIGNALING PROTEIN / Calmodulin (カルモジュリン) / TRP channel (TRPチャネル) |
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機能・相同性 | 機能・相同性情報
regulation of action potential firing rate / Activation of RAC1 downstream of NMDARs / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Cam-PDE 1 activation / CaMK IV-mediated phosphorylation of CREB / Glycogen breakdown (glycogenolysis) / Sodium/Calcium exchangers / Reduction of cytosolic Ca++ levels / Activation of Ca-permeable Kainate Receptor / Calcineurin activates NFAT ...regulation of action potential firing rate / Activation of RAC1 downstream of NMDARs / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Cam-PDE 1 activation / CaMK IV-mediated phosphorylation of CREB / Glycogen breakdown (glycogenolysis) / Sodium/Calcium exchangers / Reduction of cytosolic Ca++ levels / Activation of Ca-permeable Kainate Receptor / Calcineurin activates NFAT / CLEC7A (Dectin-1) induces NFAT activation / RHO GTPases activate PAKs / Synthesis of IP3 and IP4 in the cytosol / Inactivation, recovery and regulation of the phototransduction cascade / Calmodulin induced events / Ion transport by P-type ATPases / eNOS activation / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / gamma-aminobutyric acid secretion / Phase 0 - rapid depolarisation / Unblocking of NMDA receptors, glutamate binding and activation / Protein methylation / RAF activation / RAS processing / Ca2+ pathway / VEGFR2 mediated vascular permeability / Smooth Muscle Contraction / Extra-nuclear estrogen signaling / RHO GTPases activate IQGAPs / manganese ion transport / RAF/MAP kinase cascade / store-operated calcium channel activity / PKA activation / TRPチャネル / Platelet degranulation / cation channel complex / Stimuli-sensing channels / inositol 1,4,5 trisphosphate binding / FCERI mediated Ca+2 mobilization / Ion homeostasis / establishment of protein localization to mitochondrial membrane / calcium ion import / type 3 metabotropic glutamate receptor binding / regulation of synaptic vesicle endocytosis / response to corticosterone / organelle localization by membrane tethering / oligodendrocyte differentiation / autophagosome membrane docking / mitochondrion-endoplasmic reticulum membrane tethering / regulation of cardiac muscle cell action potential / negative regulation of high voltage-gated calcium channel activity / N-terminal myristoylation domain binding / cortical cytoskeleton / positive regulation of ryanodine-sensitive calcium-release channel activity / protein phosphatase activator activity / adenylate cyclase binding / positive regulation of cyclic-nucleotide phosphodiesterase activity / nitric-oxide synthase binding / catalytic complex / detection of calcium ion / sperm midpiece / regulation of calcium ion transport / negative regulation of ryanodine-sensitive calcium-release channel activity / regulation of cardiac muscle contraction / calcium channel inhibitor activity / positive regulation of phosphoprotein phosphatase activity / activation of adenylate cyclase activity / adenylate cyclase activator activity / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / titin binding / voltage-gated potassium channel complex / positive regulation of protein dephosphorylation / sarcomere / calcium channel complex / response to amphetamine / ミトコンドリア / regulation of ryanodine-sensitive calcium-release channel activity / regulation of cytosolic calcium ion concentration / regulation of heart rate / enzyme regulator activity / nitric-oxide synthase regulator activity / calcium ion transmembrane transport / regulation of synaptic vesicle exocytosis / regulation of cytokinesis / calcium channel activity / synaptic vesicle membrane / caveola / calcium-mediated signaling / positive regulation of DNA binding / response to calcium ion / spindle microtubule / calcium ion transport / positive regulation of nitric-oxide synthase activity / 紡錘体 / beta-catenin binding / G2/M transition of mitotic cell cycle / calcium-dependent protein binding / basolateral plasma membrane / cell-cell junction類似検索 - 分子機能 Transient receptor potential channel, canonical 4 / Transient receptor ion channel II / Transient receptor ion channel domain / Transient receptor potential channel, canonical / EF-hand domain pair / Ankyrin repeat region circular profile. / Ankyrin repeat profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily ... Transient receptor potential channel, canonical 4 / Transient receptor ion channel II / Transient receptor ion channel domain / Transient receptor potential channel, canonical / EF-hand domain pair / Ankyrin repeat region circular profile. / Ankyrin repeat profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Ion transport domain / Ion transport protein / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair類似検索 - ドメイン・相同性 Calmodulin-1 / Short transient receptor potential channel 4類似検索 - 構成要素 |
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生物種 |   Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Shen, Z.S. |
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資金援助 | 中国, 2件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 31670765 | 中国 | National Natural Science Foundation of China (NSFC) | 31870746 | 中国 |
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引用 | ジャーナル: Structure / 年: 2021 タイトル: Calmodulin binds to Drosophila TRP with an unexpected mode. 著者: Chen, W. / Shen, Z. / Asteriti, S. / Chen, Z. / Ye, F. / Sun, Z. / Wan, J. / Montell, C. / Hardie, R.C. / Liu, W. / Zhang, M. |
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履歴 | 登録 | 2020年8月11日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年6月23日 | Provider: repository / タイプ: Initial release |
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