登録情報 データベース : PDB / ID : 7c6a 構造の表示 ダウンロードとリンクタイトル Crystal structure of AT2R-BRIL and SRP2070_Fab complex 要素IgG Light Chain IgG heavy chain SAR1, ILE8-ANGIOTENSIN II Type-2 angiotensin II receptor,Soluble cytochrome b562,Type-2 angiotensin II receptor 詳細キーワード SIGNALING PROTEIN / GPCR / BRIL / Crystallization / Antibody機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure / regulation of metanephros size / regulation of systemic arterial blood pressure by circulatory renin-angiotensin / brain renin-angiotensin system / angiotensin type II receptor activity / regulation of blood volume by renin-angiotensin / response to muscle activity involved in regulation of muscle adaptation / type 2 angiotensin receptor binding / regulation of renal sodium excretion / maintenance of blood vessel diameter homeostasis by renin-angiotensin ... angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure / regulation of metanephros size / regulation of systemic arterial blood pressure by circulatory renin-angiotensin / brain renin-angiotensin system / angiotensin type II receptor activity / regulation of blood volume by renin-angiotensin / response to muscle activity involved in regulation of muscle adaptation / type 2 angiotensin receptor binding / regulation of renal sodium excretion / maintenance of blood vessel diameter homeostasis by renin-angiotensin / negative regulation of neurotrophin TRK receptor signaling pathway / positive regulation of metanephric glomerulus development / regulation of extracellular matrix assembly / receptor antagonist activity / regulation of renal output by angiotensin / : / G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger / renal system process / renin-angiotensin regulation of aldosterone production / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of extracellular matrix assembly / positive regulation of macrophage derived foam cell differentiation / vasoconstriction / positive regulation of CoA-transferase activity / type 1 angiotensin receptor binding / low-density lipoprotein particle remodeling / positive regulation of extrinsic apoptotic signaling pathway / response to angiotensin / negative regulation of blood vessel endothelial cell migration / exploration behavior / positive regulation of epidermal growth factor receptor signaling pathway / negative regulation of heart rate / positive regulation of cardiac muscle hypertrophy / : / positive regulation of gap junction assembly / positive regulation of protein tyrosine kinase activity / regulation of vasoconstriction / regulation of cardiac conduction / blood vessel remodeling / Metabolism of Angiotensinogen to Angiotensins / positive regulation of epithelial to mesenchymal transition / nitric oxide-cGMP-mediated signaling / negative regulation of MAP kinase activity / positive regulation of protein metabolic process / positive regulation of endothelial cell migration / Peptide ligand-binding receptors / positive regulation of miRNA transcription / kidney development / positive regulation of cytokine production / angiotensin-activated signaling pathway / regulation of cell growth / electron transport chain / PPARA activates gene expression / regulation of blood pressure / growth factor activity / brain development / vasodilation / hormone activity / negative regulation of cell growth / positive regulation of fibroblast proliferation / positive regulation of inflammatory response / positive regulation of reactive oxygen species metabolic process / serine-type endopeptidase inhibitor activity / cell-cell signaling / positive regulation of NF-kappaB transcription factor activity / phospholipase C-activating G protein-coupled receptor signaling pathway / regulation of cell population proliferation / G alpha (i) signalling events / G alpha (q) signalling events / collagen-containing extracellular matrix / neuron apoptotic process / regulation of apoptotic process / blood microparticle / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / periplasmic space / cell surface receptor signaling pathway / electron transfer activity / inflammatory response / iron ion binding / G protein-coupled receptor signaling pathway / heme binding / positive regulation of DNA-templated transcription / extracellular space / extracellular exosome / extracellular region / plasma membrane / cytosol 類似検索 - 分子機能 Angiotensin II receptor type 2 / Angiotensin II receptor family / Angiotensinogen, serpin domain / Angiotensinogen / : / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpin, conserved site / Serpins signature. ... Angiotensin II receptor type 2 / Angiotensin II receptor family / Angiotensinogen, serpin domain / Angiotensinogen / : / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpin, conserved site / Serpins signature. / Serpin superfamily, domain 2 / Serpin family / Serpin domain / Serpin superfamily / Serpin superfamily, domain 1 / Serpin (serine protease inhibitor) / SERine Proteinase INhibitors / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) 類似検索 - ドメイン・相同性 Angiotensinogen / Soluble cytochrome b562 / Type-2 angiotensin II receptor 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ)Homo sapiens (ヒト)Escherichia coli (大腸菌)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.4 Å 詳細データ登録者 Suzuki, M. / Miyagi, H. / Asada, H. / Yasunaga, M. / Suno, C. / Takahashi, Y. / Saito, J. / Iwata, S. 引用ジャーナル : Sci Rep / 年 : 2020タイトル : The discovery of a new antibody for BRIL-fused GPCR structure determination.著者 : Miyagi, H. / Asada, H. / Suzuki, M. / Takahashi, Y. / Yasunaga, M. / Suno, C. / Iwata, S. / Saito, J.I. 履歴 登録 2020年5月21日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2020年7月29日 Provider : repository / タイプ : Initial release改定 1.1 2023年11月29日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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