登録情報 データベース : PDB / ID : 7c4o 構造の表示 ダウンロードとリンクタイトル Solution structure of the Orange domain from human protein HES1 要素Transcription factor HES-1 詳細 キーワード SIGNALING PROTEIN / dimer / solution structure機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
trochlear nerve development / stomach neuroendocrine cell differentiation / negative regulation of stomach neuroendocrine cell differentiation / N-box binding / comma-shaped body morphogenesis / S-shaped body morphogenesis / renal interstitial fibroblast development / negative regulation of cell fate determination / negative regulation of pancreatic A cell differentiation / positive regulation of mitotic cell cycle, embryonic ... trochlear nerve development / stomach neuroendocrine cell differentiation / negative regulation of stomach neuroendocrine cell differentiation / N-box binding / comma-shaped body morphogenesis / S-shaped body morphogenesis / renal interstitial fibroblast development / negative regulation of cell fate determination / negative regulation of pancreatic A cell differentiation / positive regulation of mitotic cell cycle, embryonic / regulation of timing of neuron differentiation / midbrain-hindbrain boundary morphogenesis / common bile duct development / negative regulation of amacrine cell differentiation / ureteric bud morphogenesis / pancreatic A cell differentiation / hindbrain morphogenesis / lateral inhibition / ascending aorta morphogenesis / cardiac neural crest cell development involved in outflow tract morphogenesis / amacrine cell differentiation / glomerulus vasculature development / oculomotor nerve development / metanephric nephron tubule morphogenesis / negative regulation of calcium ion import / cell morphogenesis involved in neuron differentiation / negative regulation of pro-B cell differentiation / negative regulation of inner ear auditory receptor cell differentiation / vascular associated smooth muscle cell development / adenohypophysis development / Cajal-Retzius cell differentiation / regulation of secondary heart field cardioblast proliferation / pharyngeal arch artery morphogenesis / inner ear receptor cell stereocilium organization / establishment of epithelial cell polarity / HLH domain binding / NOTCH2 intracellular domain regulates transcription / response to thyroid hormone / inner ear auditory receptor cell differentiation / telencephalon development / neuronal stem cell population maintenance / negative regulation of oligodendrocyte differentiation / positive regulation of astrocyte differentiation / forebrain radial glial cell differentiation / cell fate determination / response to alkaloid / JUN kinase binding / positive regulation of BMP signaling pathway / negative regulation of stem cell differentiation / embryonic heart tube morphogenesis / regulation of epithelial cell proliferation / cellular response to fatty acid / Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells / RUNX3 regulates NOTCH signaling / regulation of fat cell differentiation / NOTCH4 Intracellular Domain Regulates Transcription / NOTCH3 Intracellular Domain Regulates Transcription / artery morphogenesis / regulation of receptor signaling pathway via JAK-STAT / labyrinthine layer blood vessel development / positive regulation of DNA binding / positive regulation of tyrosine phosphorylation of STAT protein / ventricular septum development / negative regulation of glial cell proliferation / smoothened signaling pathway / ventricular septum morphogenesis / negative regulation of neuron differentiation / positive regulation of Notch signaling pathway / midbrain development / E-box binding / RUNX2 regulates osteoblast differentiation / outflow tract morphogenesis / cochlea development / somatic stem cell population maintenance / cellular response to interleukin-1 / regulation of neurogenesis / BMP signaling pathway / regulation of protein-containing complex assembly / T cell proliferation / cell maturation / Notch signaling pathway / positive regulation of T cell proliferation / lung development / thymus development / transcription corepressor binding / positive regulation of receptor signaling pathway via JAK-STAT / NOTCH1 Intracellular Domain Regulates Transcription / negative regulation of forebrain neuron differentiation / liver development / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / cellular response to nerve growth factor stimulus / response to virus / DNA-binding transcription repressor activity, RNA polymerase II-specific / histone deacetylase binding / nuclear matrix / sequence-specific double-stranded DNA binding / cellular response to tumor necrosis factor / cell migration / nervous system development 類似検索 - 分子機能 Orange domain / : / Hairy Orange / Orange domain profile. / Orange domain / Helix-loop-helix DNA-binding domain / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Helix-loop-helix DNA-binding domain superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 溶液NMR / simulated annealing 詳細データ登録者 Fan, J.S. / Nayak, A. / Swaminathan, K. 引用ジャーナル : Am J Pathol / 年 : 2022タイトル: Induction of Transcriptional Inhibitor Hairy and Enhancer of Split Homolog-1 and the Related Repression of Tumor-Suppressor Thioredoxin-Interacting Protein Are Important Components of ... タイトル : Induction of Transcriptional Inhibitor Hairy and Enhancer of Split Homolog-1 and the Related Repression of Tumor-Suppressor Thioredoxin-Interacting Protein Are Important Components of Cell-Transformation Program Imposed by Oncogenic Kinase Nucleophosmin-Anaplastic Lymphoma Kinase.著者 : Zhang, Q. / Wang, H.Y. / Nayak, A. / Nunez-Cruz, S. / Slupianek, A. / Liu, X. / Basappa, J. / Fan, J.S. / Chekol, S. / Nejati, R. / Bogusz, A.M. / Turner, S.D. / Swaminathan, K. / Wasik, M.A. 履歴 登録 2020年5月18日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2021年5月19日 Provider : repository / タイプ : Initial release改定 1.1 2022年7月6日 Group : Database references / カテゴリ : citation / citation_author / database_2Item : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession 改定 1.2 2023年6月14日 Group : Other / カテゴリ : pdbx_database_status / Item : _pdbx_database_status.status_code_nmr_data改定 1.3 2024年5月15日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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