- PDB-6ngg: Crystal structure of human CD160 V58M mutant -
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Open data
ID or keywords:
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Basic information
Entry
Database: PDB / ID: 6ngg
Title
Crystal structure of human CD160 V58M mutant
Components
CD160 antigen
Keywords
IMMUNE SYSTEM / CD160 / HVEM / BTLA / gD
Function / homology
Function and homology information
positive regulation of natural killer cell mediated immune response to tumor cell / activating MHC class I receptor activity / negative regulation of CD4-positive, alpha-beta T cell costimulation / negative regulation of adaptive immune memory response / positive regulation of natural killer cell degranulation / MHC class I protein complex binding / mucosal immune response / MHC class Ib receptor activity / positive regulation of natural killer cell cytokine production / MHC class I receptor activity ...positive regulation of natural killer cell mediated immune response to tumor cell / activating MHC class I receptor activity / negative regulation of CD4-positive, alpha-beta T cell costimulation / negative regulation of adaptive immune memory response / positive regulation of natural killer cell degranulation / MHC class I protein complex binding / mucosal immune response / MHC class Ib receptor activity / positive regulation of natural killer cell cytokine production / MHC class I receptor activity / positive regulation of natural killer cell mediated cytotoxicity / positive regulation of endothelial cell apoptotic process / negative regulation of T cell receptor signaling pathway / side of membrane / T cell costimulation / negative regulation of angiogenesis / phosphatidylinositol 3-kinase/protein kinase B signal transduction / kinase binding / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / positive regulation of type II interferon production / angiogenesis / defense response to Gram-negative bacterium / adaptive immune response / innate immune response / signaling receptor binding / extracellular region / plasma membrane Similarity search - Function
Method to determine structure: MIR / Resolution: 1.95→20 Å / Cor.coef. Fo:Fc: 0.934 / Cor.coef. Fo:Fc free: 0.919 / SU B: 4.179 / SU ML: 0.122 / Cross valid method: THROUGHOUT / ESU R: 0.188 / ESU R Free: 0.176 / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.26974
854
5 %
RANDOM
Rwork
0.21714
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obs
0.21974
16088
99.24 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å